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J-GLOBAL ID：201702225480855545   整理番号：17A0759266

印刷3D心臓構築物のための金ナノ複合材料Bioink【Powered by NICT】

Gold Nanocomposite Bioink for Printing 3D Cardiac Constructs

著者 (38件)： Zhu Kai (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Zhu Kai (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Zhu Kai (Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China) ,  Shin Su Ryon (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Shin Su Ryon (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Shin Su Ryon (Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA) ,  van Kempen Tim (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  van Kempen Tim (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Li Yi-Chen (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Li Yi-Chen (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Li Yi-Chen (Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA) ,  Ponraj Vidhya (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Ponraj Vidhya (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Nasajpour Amir (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Nasajpour Amir (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Mandla Serena (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Mandla Serena (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Mandla Serena (Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA) ,  Hu Ning (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Hu Ning (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Liu Xiao (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Liu Xiao (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Leijten Jeroen (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Leijten Jeroen (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Leijten Jeroen (Department of Developmental BioEngineering, University of Twente, Enschede, Overijssel, 7522 NB, The Netherlands) ,  Lin Yi-Dong (Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA) ,  Hussain Mohammad Asif (Department of Electrical and Computer Engineering, King Abdulaziz University, Jeddah, 21569, Saudi Arabia) ,  Zhang Yu Shrike (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Zhang Yu Shrike (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Zhang Yu Shrike (Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA) ,  Tamayol Ali (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Tamayol Ali (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Tamayol Ali (Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA) ,  Khademhosseini Ali (Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA) ,  Khademhosseini Ali (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA) ,  Khademhosseini Ali (Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA) ,  Khademhosseini Ali (Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul, 143-701, Republic of Korea) ,  Khademhosseini Ali (Department of Physics, King Abdulaziz University, Jeddah, 21569, Saudi Arabia)
資料名： Advanced Functional Materials  (Advanced Functional Materials)
巻： 27  号： 12  ページ： ROMBUNNO.201605352  発行年： 2017年 
JST資料番号： W1336A  ISSN： 1616-301X  CODEN： AFMDC6  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： バイオプリンティングは,生体模倣三次元(3D)心臓組織構築物,損傷を受けた組織の再生と薬物スクリーニングのためのプラットホームを提供するために使用できることを作成するために最も便利な微細加工法である。しかし,既存bioinks,通常高分子生体材料から構成される,不十分な導電性および隣接する心臓細胞間の効率的な電気的結合を遅らせた。この問題を解決するために,金ナノロッド(GNR)を組み込んだゼラチンメタクリロイル(GelMA)をベースにした生物インク印刷3D機能的心臓組織構築物のために開発した。GNR濃度は心臓細胞の広がりと組織化のための適切な微小環境を作成するために調整した。GNRの最適濃度で,ナノ複合材料生物インクは,元のインクに類似し,それは高密度で細胞の容易な統合を可能にする低粘度を有していた。結果として,高分解能で細胞運搬性繊維の急速な堆積が可能である,カプセル化した細胞にせん断応力を減少させた。プリントGNR構築物では,GNRのない構築物と比較した場合,心臓細胞は,改善された細胞接着と組織を示した。さらに,ポリマの細孔壁電気的抵抗性導入GNR橋,細胞間結合を改善し,バイオプリント構築物の同期収縮を促進した。その有利な性質を考えると,この金ナノ複合材料生物インクは心臓組織工学における広い応用を見出すであろう。Copyright 2017 Wiley Publishing Japan K.K. All Rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 剪断応力 ,  インク ,  *ナノ複合材料 ,  細胞接着 ,  微細加工 ,  *印刷 ,  *金 ,  心筋細胞 ,  重合体 ,  高分子 ,  *三次元 ,  *心臓 ,  ゼラチン
準シソーラス用語： 生体材料 ,  生体模倣 , 【Automatic Indexing@JST】

著者キーワード (5件)： アルギン酸塩 ,  バイオプリンティング ,  心臓組織工学 ,  ゼラチン ,  金ナノロッド

分類 (2件)： 医用素材  (GA05040H) ,  細胞・組織培養法  (EA03040R)

タイトルに関連する用語 (5件)： 3D ,  心臓 ,  構築物 ,  金 ,  ナノ複合材料