Rchr
J-GLOBAL ID：200901047247681811   Update date: Oct. 15, 2024

Sekiguchi Kiyotoshi

セキグチ キヨトシ | Sekiguchi Kiyotoshi
Affiliation and department：
Osaka University Institute for Protein Research

About Osaka University Institute for Protein Research


Job title： Endowed Chair and Distinguished Professor
Research field  (3)： Structural biochemistry ,  Functional biochemistry ,  Cell biology
Research keywords  (5)： Basement membrane ,  Stem cell ,  Regenerative medicine ,  Connective tissue ,  Extracellular matrix
Research theme for competitive and other funds  (74)：
  • 2023 - 2028 領域研究「細胞外情報を統御するマルチモーダルECM」の統括と運営
  • 2020 - 2023 Elucidation of the mechanism of whole eye development and its reproduction in vitro by regulating scaffold environment using pluripotent stem cells
  • 2020 - 2023 次世代型マトリックスによる高効率骨格筋幹細胞分化誘導法の開発
  • 2020 - 2022 再構成基底膜ゲルを用いる移植心筋細胞の生着・成熟促進技術の開発
  • 2014 - 2019 Development of Manufacturing Systems for Human iPS Cell-derived Products for Regenerative Medicine
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Papers (219)：
  • Shun Yoshida, Takafumi Hasegawa, Takaaki Nakamura, Kazuki Sato, Naoto Sugeno, Shun Ishiyama, Kiyotoshi Sekiguchi, Muneshige Tobita, Atsushi Takeda, Masashi Aoki. Dysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson's disease. Cell death discovery. 2024. 10. 1. 290-290
  • Akina Yamada, Toshiki Takei, Toru Kawakami, Yukimasa Taniguchi, Kiyotoshi Sekiguchi, Hironobu Hojo. Application of cysteinyl prolyl ester for the synthesis of cyclic peptides containing an RGD sequence and their biological activity measurement. Frontiers in Chemistry. 2024. 12
  • Mingming Zhao, Yukimasa Taniguchi, Chisei Shimono, Tatsuya Jonouchi, Yushen Cheng, Yasuhiro Shimizu, Minas Nalbandian, Takuya Yamamoto, Masato Nakagawa, Kiyotoshi Sekiguchi, et al. Heparan Sulfate Chain-Conjugated Laminin-E8 Fragments Advance Paraxial Mesodermal Differentiation Followed by High Myogenic Induction from hiPSCs. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024. e2308306
  • Yu-Shen Cheng, Yukimasa Taniguchi, Yasuhiro Yunoki, Satomi Masai, Mizuho Nogi, Hatsuki Doi, Kiyotoshi Sekiguchi, Masato Nakagawa. Simultaneous binding of bFGF to both FGFR and integrin maintains properties of primed human induced pluripotent stem cells. Regenerative therapy. 2024. 25. 113-127
  • Luo Qianwen, 加藤 寛子, 原 武史, 種村 篤, 中川 幸延, 室田 浩之, 富永 真琴, 関口 清俊, 藤田 郁尚. ヒトエクリン汗腺におけるTRPチャネルの発現と機能の解析. 発汗学. 2023. 30. 2. 43-45
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MISC (130)：
  • 中島輝恵, 倉田隆一郎, 倉田隆一郎, 藤田郁尚, 藤田郁尚, 室田浩之, 種村篤, 岡田文裕, 関口清俊. ギャップ結合を介した筋上皮細胞収縮によるヒトエクリン汗腺の分節収縮は汗の運搬を引き起こす. 日本発汗学会総会抄録集・プログラム. 2021. 29th
  • 柴田峻, 柴田峻, 林竜平, 工藤裕司, 工藤裕司, 大久保徹, 大久保徹, 今泉務, 今泉務, 片山朋彦, et al. Cell-type-specific adhesion to laminin isoforms and cell competition enable purification of iPS cell-derived corneal epithelium. 日本結合組織学会学術大会抄録集. 2020. 52nd
  • 倉田 隆一郎, 藤田 郁尚, 岡田 文裕, 二木 杉子, 中野 伊津子, 種村 篤, 室田 浩之, 片山 一朗, 関口 清俊. ヒト汗腺の構造と再生. 日本皮膚科学会雑誌. 2019. 129. 5. 993-993
  • TAKIZAWA Mamoru, ARIMORI Takao, TANIGUCHI Yukimasa, TAKAGI Junichi, SEKIGUCHI Kiyotoshi. Mechanistic Basis for the Laminin Recognition by Integrin. Seibutsu Butsuri. 2019. 59. 2. 91-93
  • 柴田峻, 柴田峻, 林竜平, 工藤裕司, 工藤裕司, 大久保徹, 大久保徹, 片山朋彦, 石川幸, 小林由紀, et al. iPS角膜上皮シート作製工程の効率化検討-FACSを用いない角膜上皮細胞単離法の開発-. 日本再生医療学会総会(Web). 2019. 18th
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Patents (17)：
  • Chimeric protein comprising a fibrinogen fragment and a laminin fragment and use thereof
  • 特定のラミニン上での多能性幹細胞の培養方法
  • Method for inducing differentiation of pluripotent stem cells into somatic cells
  • 網膜色素上皮細胞の純化方法
  • Method for inducing dopaminergic neuron progenitor cells
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Books (28)：
  • Protocols in Extracellular Matrix Research
    4-4. Interactions of extracellular matrix with integrins: Tissue levels 2021
  • Protocols in Extracellular Matrix Research
    8-7. Cultivation of human iPS cells on laminin fragments 2021
  • Protocols in Extracellular Matrix Research
    4-2. Cell adhesion assay onto extracellular matrices 2021
  • Protocols in Extracellular Matrix Research
    4-1. Cell-matrix interactions: Overview 2021
  • Why Hearts do not stop beating: Primers for Protein Research
    2018
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Lectures and oral presentations  (44)：
  • 多細胞体制と細胞外マトリックス:なぜ細胞に足場が必要か?
    (「幹細胞の培養法・培養工学のためのコンソーシアム」第7回シンポジウム 2023)
  • Roles of extracellular matrix in multicellularity: why cells need to adhere to proliferate?
    (CiRA Seminar 2023)
  • Next-generation culture substrates for stem cells based on matrixome research
    (The 26th annual Meeting of the Japanese Society for the Research of Hepatic Cells 2019)
  • Development of culture substrates for stem cells
    (Advances in Cell Manufacturing Technologies for Regenerative Medicine 2018)
  • Next-generation culture substrates for stem cells based on matrixome research
    (The 16th Annual Symposium of Japan Consortium for Glycobiology and Glycotechnology 2018)
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Education (2)：
  • 1973 - 1978 Osaka University Graduate School, Faculty of Science Biological Chemistry
  • 1969 - 1973 Tokyo Institute of Technology Faculty of Science Department of Chemistry
Professional career (1)：
  • Ph.D. (Osaka University)
Work history (12)：
  • 2023/04 - 現在 Osaka University Distinguished Professor
  • 2016/04 - 現在 Osaka University Institute for Protein Research Endowed Chair and Professor
  • 1998/04 - 2016/03 Osaka University Institute for Protein Research Professor
  • 2000/10 - 2006/03 ERATO Sekiguchi Biomatrix Signaling Project Project Director
  • 1992/04 - 1998/03 Osaka Medical Center for Maternal and Child Health Research Institute Director
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Committee career (5)：
  • 2019 - 現在 The Japanese Society for Perspiration Research Councilor
  • 2010/02 - 現在 Japan Leather Research Institute Director
  • 1998 - 現在 The Japanese Society for Matrix Biology and Medicine Councilor
  • 2014/06 - 2023/12 Osaka International Cancer Institute Research Institute Evaluation Committee
  • 1997 - 2007 Japanese Society for Tissue Engineering Director
Awards (10)：
  • 2023/04 - Cabinet Office Medal with Purple Ribbon
  • 2021/08 - Japan Science and Technology Agency President's Award from the Japan Academic Society for Ventures and Entrepreneurs Matrixome, Inc
  • 2020/10 - Japan Institute of Invention and Innovation Future Creation Invention Award Development of culture substrates for human pluripotent stem cells suitable for clinical applications
  • 2017/06 - Japanese Society for Matrix Biology and Medicine Distinguished Merit Award
  • 2016/04 - Ministry of Education, Culture, Sports, Science and Technology Distinguished Service Award from Minister of Edulation, Culture, Sports, Science and Technology Award in Science and Technology, R&D Division
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Association Membership(s) (7)：
THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE ,  International Society for Stem Cell Research ,  The Japanese Society for Matrix Biology and Medicine ,  The Japanese Biochemical Society ,  Japanese Society for Matrix Biology and Medicine ,  American Society for Cell Biology ,  American Society for Biochemistry and Molecular Biology
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