Rchr
J-GLOBAL ID:200901047247681811
Update date: Jul. 19, 2024
Sekiguchi Kiyotoshi
セキグチ キヨトシ | Sekiguchi Kiyotoshi
Affiliation and department:
Job title:
Endowed Chair and Distinguished Professor
Research field (3):
Structural biochemistry
, Functional biochemistry
, Cell biology
Research keywords (5):
Basement membrane
, Stem cell
, Regenerative medicine
, Connective tissue
, Extracellular matrix
Research theme for competitive and other funds (74):
- 2023 - 2028 領域研究「細胞外情報を統御するマルチモーダルECM」の統括と運営
- 2020 - 2023 Elucidation of the mechanism of whole eye development and its reproduction in vitro by regulating scaffold environment using pluripotent stem cells
- 2020 - 2023 次世代型マトリックスによる高効率骨格筋幹細胞分化誘導法の開発
- 2020 - 2022 再構成基底膜ゲルを用いる移植心筋細胞の生着・成熟促進技術の開発
- 2014 - 2019 Development of Manufacturing Systems for Human iPS Cell-derived Products for Regenerative Medicine
- 2016 - 2018 Analysis of three-dimensional structure of human sweat glands
- 2013 - 2018 Development of culture substrates for stem cells
- 2015 - 2017 Basement membrane live-imaging
- 2013 - 2017 Regulatory mechanisms of cellular functions by integrins and their ligands
- 2013 - 2016 Molecular mechanism underlying cell adhesion to basement membrane laminins
- 2010 - 2016 Management of the research group of Neuro-vascular Wiring
- 2010 - 2015 Regulation of neuro-vascular interaction by extracellular matrix and their receptors
- 2010 - 2012 Cell adhesion machineries on basement membrane laminins
- 2009 - 2011 Development of the new cell-free device for sever heart failure by restructuring of artificial stem cell niche using extracellular matrixes and stem cell recruitment/differentiation factors
- 2008 - 2010 Molecular mechanisms of basement membrane recognition by integrins
- 2005 - 2009 Customization and cellular recognition of the extracellular matrix
- 2007 - 2008 Molecular mechanisms underlying regulation of epithelial cell functions by laminins through integrin a3b1-based protein complex
- 2006 - 2007 Mechanisms of basement membrane recognition by cell with special reference to cell adhesion-dependent signal transduction
- 2005 - 2007 Development of periodontal ligament regeneration therapy using novel extracellular matrix
- 2005 - 2005 細胞外基質因子による腫瘍増殖制御の分子機構
- 2004 - 2005 基底膜による上皮の形成および機能分化の制御機構
- 2003 - 2005 Regulatory mechanisms of ligand binding and signaling events of laminin-binding integrins
- 2004 - 2004 細胞外基質因子による腫瘍血管新生の制御機構の解析
- 2003 - 2003 細胞外基質因子による腫瘍血管新生の制御機構の解析
- 2002 - 2003 Development of novel strategy for targeting of functional proteins into hasement membrance
- 2002 - 2003 Studies on integrinα3β1-mediated signaling
- 2002 - 2003 基底膜による上皮組織の形成および再生の制御機構
- 2002 - 2002 細胞間接着部位に局在するインテグリンα3β1-CD151複合体の機能解析
- 2000 - 2002 Studies on the Regulatory Mechanisms and Molecular Diversity of Integrinmediated Signal Transduction
- 2001 - 2001 細胞外基質によるがん細胞の機能制御機構
- 1999 - 2001 Engineering of Artificial Biomatrix through Extracellular Matrix Targeting of Functional Proteins
- 2000 - 2000 細胞外マトリックスを標的とした新しいバイオターゲティング技術の開発とその応用
- 1999 - 1999 基底幕による細胞機能制御の分子的基盤の解明
- 1999 - 1999 細胞外マトリックスを標的とした新しいバイオターゲティング技術の開発とその応用
- 1998 - 1999 MECHANISMS AND VARIATIONS OF INTEGRIN-MEDIATED SIGNAL TRANSDUCTION
- 1998 - 1999 SIGNAL TRANSDUCTION BY INTEGRIN-MATRIX INTERACTION
- 1998 - 1998 選択的スプライシングによるフィブロネクチンの活性化と癌細胞増殖制御
- 1998 - 1998 細胞外マトリックスを標的とした新しいバイオターゲティング技術の開発とその応用
- 1997 - 1998 The role of membrane-anchored HB-EGF on cell growth
- 1997 - 1997 フィブロネクチンの自己会合ドメインを利用した新機能細胞外超構造の構築
- 1996 - 1996 基底膜結合型インテグリンの認識ペプチド配列の検索
- 1996 - 1996 癌細胞の増殖と転移を支える細胞外基質/インテグリン系の解析とその応用
- 1996 - 1996 フィブロネクチンの自己会合ドメインを利用した新機能細胞外超構造の構築
- 1995 - 1996 STUDIES ON MOLECULAR MECHANISMS AND PHYSIOLOGICAL FUNCTIONS OF ANTI-CELL ADHESION
- 1995 - 1996 Role of Integrin-mediated Signal Transduction in Cell Growth and Differentiation
- 1994 - 1996 Juxtacrine stimulation of cellular communication by HB-EGF.
- 1995 - 1995 ランダムペプチドライブラリーを利用した非RGD型インテグリンの認識ペプチドの検索
- 1995 - 1995 癌細胞形質発現におけるフィブロネクチンマトリックスの役割
- 1995 - 1995 癌細胞の増殖と転移を支える細胞外基質/インテグリン系の解析とその応用
- 1995 - 1995 フィブロネクチンの自己会合ドメインを利用した新機能細胞外超構造の構築
- 1994 - 1994 RGD依存性および非依存性インテグリンのリガンド認識特異性の解明
- 1994 - 1994 癌細胞の浸潤・転移におけるインテグリンファミリーの役割
- 1991 - 1993 Structure and function of adhesive molecules involved in platelet aggregation and other lymphoid cell interactions.
- 1991 - 1993 THE ANALYSIS OF CELL ADHESION SIGNALS : POSSIBLE CLINICAL APPLICATIONS
- 1992 - 1992 組織器官形成促進材料
- 1991 - 1991 インテグリンファミリ-によるRGD細胞接着分子の認識特異性の解析
- 1991 - 1991 組織器官形成促進材料
- 1990 - 1990 フィブロネクチンのRGD依存性および非依存性細胞接着シグナルの蛋白工学的機能解析
- 1990 - 1990 細胞接着の分子機構と細胞機能発現
- 1990 - 1990 ヒト癌における組織特異的alternative splicingの脱制御の検証
- 1989 - 1989 PGD蛋白質をはじめとする細胞接着因子の機能と臨床応用に関する総合的研究
- 1989 - 1989 ヒト癌におけるalternative splicingの脱制御の検証
- 1989 - 1989 ヒト肺線癌の特性の分子病理学的解析
- 1989 - 1989 がん細胞接着システムの制御機構
- 1987 - 1989 Studies on platelet aggregation by structural analysis of von Willebrand factor
- 1988 - 1988 細胞接着因子と細胞機能調節
- 1988 - 1988 ヒト肺腺癌の特性の分子病理学的解析
- 1988 - 1988 がん細胞接着システムの制御機構
- 1987 - 1987 遺伝子工学的にドメイン構造を改変したフィブロネクチン分子:培養細胞での発現の試み
- 1987 - 1987 ヒト肺腺癌の特性の分子病理学的解析
- 1987 - 1987 がん細胞接着システムの制御機構
- 1986 - 1987 癌および胎児組織にみられる細胞接着分子フィブロネクチンの異常とその生理的意義
- Design of Artificial Extracellular Environment
- Biochemical Studies on Cell Adhesion Molecules
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Papers (217):
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Shun Yoshida, Takafumi Hasegawa, Takaaki Nakamura, Kazuki Sato, Naoto Sugeno, Shun Ishiyama, Kiyotoshi Sekiguchi, Muneshige Tobita, Atsushi Takeda, Masashi Aoki. Dysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson's disease. Cell death discovery. 2024. 10. 1. 290-290
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Mingming Zhao, Yukimasa Taniguchi, Chisei Shimono, Tatsuya Jonouchi, Yushen Cheng, Yasuhiro Shimizu, Minas Nalbandian, Takuya Yamamoto, Masato Nakagawa, Kiyotoshi Sekiguchi, et al. Heparan Sulfate Chain-Conjugated Laminin-E8 Fragments Advance Paraxial Mesodermal Differentiation Followed by High Myogenic Induction from hiPSCs. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024. e2308306
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Yu-Shen Cheng, Yukimasa Taniguchi, Yasuhiro Yunoki, Satomi Masai, Mizuho Nogi, Hatsuki Doi, Kiyotoshi Sekiguchi, Masato Nakagawa. Simultaneous binding of bFGF to both FGFR and integrin maintains properties of primed human induced pluripotent stem cells. Regenerative therapy. 2024. 25. 113-127
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Luo Qianwen, 加藤 寛子, 原 武史, 種村 篤, 中川 幸延, 室田 浩之, 富永 真琴, 関口 清俊, 藤田 郁尚. ヒトエクリン汗腺におけるTRPチャネルの発現と機能の解析. 発汗学. 2023. 30. 2. 43-45
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Kie Nakashima, Hiroko Kato, Ryuichiro Kurata, Luo Qianwen, Tomohisa Hayakawa, Fumihiro Okada, Fumitaka Fujita, Yukinobu Nakagawa, Atsushi Tanemura, Hiroyuki Murota, et al. Gap junction-mediated contraction of myoepithelial cells induces the peristaltic transport of sweat in human eccrine glands. Communications biology. 2023. 6. 1. 1175-1175
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MISC (130):
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中島輝恵, 倉田隆一郎, 倉田隆一郎, 藤田郁尚, 藤田郁尚, 室田浩之, 種村篤, 岡田文裕, 関口清俊. ギャップ結合を介した筋上皮細胞収縮によるヒトエクリン汗腺の分節収縮は汗の運搬を引き起こす. 日本発汗学会総会抄録集・プログラム. 2021. 29th
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柴田峻, 柴田峻, 林竜平, 工藤裕司, 工藤裕司, 大久保徹, 大久保徹, 今泉務, 今泉務, 片山朋彦, et al. Cell-type-specific adhesion to laminin isoforms and cell competition enable purification of iPS cell-derived corneal epithelium. 日本結合組織学会学術大会抄録集. 2020. 52nd
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倉田 隆一郎, 藤田 郁尚, 岡田 文裕, 二木 杉子, 中野 伊津子, 種村 篤, 室田 浩之, 片山 一朗, 関口 清俊. ヒト汗腺の構造と再生. 日本皮膚科学会雑誌. 2019. 129. 5. 993-993
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TAKIZAWA Mamoru, ARIMORI Takao, TANIGUCHI Yukimasa, TAKAGI Junichi, SEKIGUCHI Kiyotoshi. Mechanistic Basis for the Laminin Recognition by Integrin. Seibutsu Butsuri. 2019. 59. 2. 91-93
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柴田峻, 柴田峻, 林竜平, 工藤裕司, 工藤裕司, 大久保徹, 大久保徹, 片山朋彦, 石川幸, 小林由紀, et al. iPS角膜上皮シート作製工程の効率化検討-FACSを用いない角膜上皮細胞単離法の開発-. 日本再生医療学会総会(Web). 2019. 18th
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Patents (17):
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Chimeric protein comprising a fibrinogen fragment and a laminin fragment and use thereof
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特定のラミニン上での多能性幹細胞の培養方法
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Method for inducing differentiation of pluripotent stem cells into somatic cells
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網膜色素上皮細胞の純化方法
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Method for inducing dopaminergic neuron progenitor cells
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Books (28):
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Protocols in Extracellular Matrix Research
4-4. Interactions of extracellular matrix with integrins: Tissue levels 2021
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Protocols in Extracellular Matrix Research
8-7. Cultivation of human iPS cells on laminin fragments 2021
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Protocols in Extracellular Matrix Research
4-2. Cell adhesion assay onto extracellular matrices 2021
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Protocols in Extracellular Matrix Research
4-1. Cell-matrix interactions: Overview 2021
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Why Hearts do not stop beating: Primers for Protein Research
2018
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Lectures and oral presentations (44):
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多細胞体制と細胞外マトリックス:なぜ細胞に足場が必要か?
(「幹細胞の培養法・培養工学のためのコンソーシアム」第7回シンポジウム 2023)
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Roles of extracellular matrix in multicellularity: why cells need to adhere to proliferate?
(CiRA Seminar 2023)
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Next-generation culture substrates for stem cells based on matrixome research
(The 26th annual Meeting of the Japanese Society for the Research of Hepatic Cells 2019)
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Development of culture substrates for stem cells
(Advances in Cell Manufacturing Technologies for Regenerative Medicine 2018)
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Next-generation culture substrates for stem cells based on matrixome research
(The 16th Annual Symposium of Japan Consortium for Glycobiology and Glycotechnology 2018)
more...
Education (2):
- 1973 - 1978 Osaka University Graduate School, Faculty of Science Biological Chemistry
- 1969 - 1973 Tokyo Institute of Technology Faculty of Science Department of Chemistry
Professional career (1):
Work history (12):
- 2023/04 - 現在 Osaka University Distinguished Professor
- 2016/04 - 現在 Osaka University Institute for Protein Research Endowed Chair and Professor
- 1998/04 - 2016/03 Osaka University Institute for Protein Research Professor
- 2000/10 - 2006/03 ERATO Sekiguchi Biomatrix Signaling Project Project Director
- 1992/04 - 1998/03 Osaka Medical Center for Maternal and Child Health Research Institute Director
- 1991/07 - 1998/03 Oaka Medical Center for Maternal and Child Health Division of Pathobiology Chief
- 1991/04 - 1991/06 Osaka University Research Institute for Microbial Diseases Assistant Professor
- 1990/06 - 1991/03 Fujita Health University Institute for Comprehensive Medical Science Assistant Professor
- 1986/05 - 1990/05 Fujita Health University Institute for Comprehensive Medical Science Instructor
- 1984/07 - 1986/12 Fred Hutchinson Cancer Research Center Division of Biochemical Oncology Associate
- 1979/03 - 1984/06 Fred Hutchinson Cancer Research Center Division of Biochemical Oncology Postdoctoral Fellow
- 1978/04 - 1979/03 Osaka University Institute for Protein Research Postdoctoral Fellow
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Committee career (5):
- 2019 - 現在 The Japanese Society for Perspiration Research Councilor
- 2010/02 - 現在 Japan Leather Research Institute Director
- 1998 - 現在 The Japanese Society for Matrix Biology and Medicine Councilor
- 2014/06 - 2023/12 Osaka International Cancer Institute Research Institute Evaluation Committee
- 1997 - 2007 Japanese Society for Tissue Engineering Director
Awards (10):
- 2023/04 - Cabinet Office Medal with Purple Ribbon
- 2021/08 - Japan Science and Technology Agency President's Award from the Japan Academic Society for Ventures and Entrepreneurs Matrixome, Inc
- 2020/10 - Japan Institute of Invention and Innovation Future Creation Invention Award Development of culture substrates for human pluripotent stem cells suitable for clinical applications
- 2017/06 - Japanese Society for Matrix Biology and Medicine Distinguished Merit Award
- 2016/04 - Ministry of Education, Culture, Sports, Science and Technology Distinguished Service Award from Minister of Edulation, Culture, Sports, Science and Technology Award in Science and Technology, R&D Division
- 2015/08 - Cabinet Office Distinguished Service Awards for Industry-Academia-Government Collaboration Award from Minister of Education, Culture, Sports, Science and Technology
- 2014/07 - Osaka University President Award for Research
- 2013/08 - Osaka University President Award for Research
- 1997/10 - Japanese Biochemical Society JB Award, Japanese Biochemical Society
- 1985/03 - National Institute of Health, USA New Investigator Research Award, National Institute of health, USA
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Association Membership(s) (7):
THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, International Society for Stem Cell Research
, The Japanese Society for Matrix Biology and Medicine
, The Japanese Biochemical Society
, Japanese Society for Matrix Biology and Medicine
, American Society for Cell Biology
, American Society for Biochemistry and Molecular Biology
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