MASAYUKI AMAGAI

2017 - 2020 ステロイド治療抵抗性の天疱瘡患者を対象としたリツキシマブの医師主導治験

2017 - 2020 稀少難治性皮膚疾患に関する調査研究

2017 - 2019 Integrated system analysis method of epidermal barrier function

2016 - 2019 Elucidation for mechanism of dermatitis with model mice which develop dermatitis spontaneously with S.aureus proliferation.

2016 - 2019 皮膚・腸内微生物叢解析によるアトピー性皮膚炎発症機序の解明

2015 - 2018 3D analysis of the oral mucosa epithelium barrier function

2015 - 2017 ガイドライン最適化を目的とした自己免疫性水疱症に対する抗CD20抗体療法の評価

2014 - 2017 Molecular mechanism of skin inflammation induced by desmoglein 3-specific T cells

2014 - 2017 Molecular mechanisms for the epidermal barrier homeostasis

2014 - 2017 Clarification of the pathogenesis of atopic disease by using filaggrin deficient mice in dry environment

2014 - 2017 Clarification of peripheral tolerance mechanism involved in the onset of autoimmune skin diseases

2014 - 2017 天疱瘡抗原に対する中枢性、末梢性免疫寛容機構の解明

2014 - 2017 稀少難治性皮膚疾患に関する調査研究

2014 - 2016 Effects of cancer-testis antigens on the signaling and biological activity of the malignant melanoma cells

2013 - 2016 Attempt to regenerate hair follicles using human iPS cell-derived epithelial and mesenchymal cells optimized for trichogenicity

2013 - 2016 Analysis of the activation mechanism of autoreactive B cells in pemphigus

2013 - 2016 アトピー性皮膚炎発症機序の解明と皮膚バリアケアによる予防法の開発に関する研究

2012 - 2015 ランゲルハンス細胞が誘導する経皮液性免応答の制御機構

2012 - 2015 Elucidation of the mechanism by which pemphigus vulgaris autoantibodies cause cellular signaling in human keratinocytes

2010 - 2014 Analysis of the dynamic skin immune and physical barrier system by tight junctions and Langerhans cells

2009 - 2014 Clarification of the molecular and cellular mechanisms of central and peripheral tolerance to pemphigus autoantigen

2011 - 2012 ヒトiPS細胞からの毛包バルジ幹細胞作成の試み

2011 - 2012 Investigation of roles of miRNA in the immunosuppression and clinical use for patients with melanoma

2008 - 2010 Development of new objective methods to assess disease activity in pemphigus using monoclonal single-chain- variable-fragment antibodies

2008 - 2009 The analysis of centrosome replication cycle in Bowen's disease

2006 - 2008 Experimental regeneration of human hair follicles using CD200 positive bulge cells

2005 - 2008 Elucidation of tolerance mechanism against peripheral target antigens in autoimmune diseases

2006 - 2007 Analysis of pathophysiology of pemphigus foliaceus by using immunoelectron microscopy

2005 - 2006 Establishment of optimal tissue regenerating procedures using monocyte-derived multipotential cells for tissue regeneration

2003 - 2004 天疱瘡自己抗体の病的活性測定法の開発

2003 - 2004 Molecular basis of keratinocyte desmosomes and acantholysis using imunoelectron microscopy

2002 - 2004 Real-time imaging analysis of cell adhesion molecules of epidermal keratinocytes

2001 - 2004 Clarification of pathophysiological mechanisms of autoimmune skin disease, pemphigus

2002 - 2003 抗CD40Lモノクローナル抗体を用いた新しい免疫抑制療法の開発

2001 - 2002 天疱瘡病的自己抗体の認識する3次元エピトープの解析

2001 - 2002 Mechanisms of B cell tolerance against peripheral antigen

2001 - 2001 伝染性膿痂疹およびブドウ球菌性熱傷様皮膚症候群における水疱形成機序の解明

2000 - 2001 Evaluation of immune suppressive therapy using autoimmune model mouse

2000 - 2001 Basic studies for development of disease-specific therapeutic strategies against autoimmune diseases

2000 - 2001 Elucidation of the pathomechanism of epidermolysis bullosa - muscular dystrophy syndrome

1999 - 2001 Development of immune supression against gene product in gene therapy

1999 - 2000 抗原抗体反応速度論的解析による自己抗体病原性強度の新しい指標の開発

1999 - 2000 Study on pathophysiological mechanism of autoantibody production in pemphigus

1999 - 2000 Cellular mechanisms of tolerance breakdown in autoantibody production

1998 - 1999 Development and Characterization of Desmoglein-3 Specific T cells from Japanese Patients with Pemphigus Vulgaris

1998 - 1999 Elucidation of Pathogenetic Mechanisms of Severe Ichthyoses and Establishment of New Method for the Diagnosis and Prenatal Disease Detection

1998 - 1999 Development of novel mouse model for autoimmune diseases using autoantigen knockout mice

1998 - 1999 Development of novel therapy against bullous diseases

1997 - 1999 Research of disease selective immunotherapy in autoimmune diseases

1997 - 1998 Naked DNA Injectionによる表皮細胞への遺伝子導入法の開発

1997 - 1998 Development of disease activity monitoring assay system by ELISA using recombinant pemphigus antigens

1997 - 1998 Development of antigen-specific B cell elimination by recombinant toxins in autoimmune diseases

1997 - 1998 Gene therapy for epidermolysis bullosa using cultured keratinocytes sheet

1995 - 1996 Development of a novel diagnostic tool using recombinant pemphigus antigens with the proper native conformation.

1995 - 1996 Molecular basis of Japanese with Herlitz epidermolysis bullosa and Its application to the diagnosis and prenatal diagnosis

1995 - 1995 デスモヨ-キンの角化細胞間接着における機能の解析と皮膚疾患への関与の検討

1993 - 1995 Clarification of pathogenesis in pemphigus : Establishment of new techniques for diagnosis.

1994 - 1994 角化細胞間接着におけるデスモヨ-キンの機能の解析

1993 - 1994 Basic studies for the pathogenesis and diagnosis of the autoimmune bullous diseases

1990 - 1991 Basic studies for the diagnosis of bullous diseases having pathologic changes at the basement membrane zone