Rchr
J-GLOBAL ID:200901006723262328
Update date: Apr. 09, 2024
Sekido Yoshitaka
セキド ヨシタカ | Sekido Yoshitaka
Affiliation and department:
Job title:
Chief
Other affiliations (1):
-
名古屋大学
大学院医学系研究科 がん分子病因・病態学講座 がん分子病因学分野
連携教授
Homepage URL (1):
http://www.pref.aichi.jp/cancer-center/400/420/421/421-03.html
Research field (3):
Respiratory medicine
, Pathobiochemistry
, Molecular biology
Research keywords (9):
tumor suppressor gene
, oncogene
, signal transduction
, 中皮腫
, 肺癌
, 分子腫瘍学
, Mesothelioma
, Lung Cancer
, Molecular Oncology
Research theme for competitive and other funds (20):
- 2023 - 2026 ピリミジン塩基合成経路を標的としたLKB1不活化肺癌に対する新規治療法の開発
- 2022 - 2024 Elucidation of the mechanism of accelerated induction of entosis in malignant mesothelioma cells
- 2020 - 2023 悪性中皮腫におけるオキシトシン受容体を標的とした新規治療法の開発
- 2019 - 2022 Development of a new therapeutic modality using YAP1/TAZ inhibitors against malignant mesothelioma
- 2017 - 2020 Development of a novel therapeutic modality against both cancerous and inflammatory diseases based on the understanding of the characteristics of mesothelial cells
- 2016 - 2019 Development of novel molecular diagnostic and therapeutic tools based on genomic information of malignant mesothelioma
- 2013 - 2016 Identification of genes which shows synthetic lethality in malignant mesothelioma cells and application of them in clinics
- 2012 - 2014 Development of a new therapeutic tool against malignant mesothelioma
- 2010 - 2012 Identification of genetic alterations in malignant mesothelioma and the development of new molecular diagnostic tools
- 2006 - 2008 Identification of new therapeutic target molecules and development of diagnostic markers for malignant mesothelioma
- 2004 - 2005 Identification of new cancer-associated genes at the frequent chromosomal deletion regions of lung cancer
- 2002 - 2003 Identification and functional analysis of a novel cancer related gene from lung cancer and malignant mesothelioma
- 2002 - 2003 ESTABLISHMENT OF PERSONALIZED CHEMOTHERAPY OF LUNG CANCER APPLYING PHARMACOGENOMICS
- 2001 - 2001 薬物代謝関連酵素の遺伝子多型解析とその個別化がん化学療法への応用
- 2000 - 2001 Identification of a tumor suppressor gene of malignant mesothelioma and functional analysis of the NF2 and p16 genes
- 2000 - 2000 薬物代謝関連酵素の遺伝子多型解析とその個別がん化学療法への応用
- 中皮腫の分子生物学的研究
- 肺癌の分子生物学的研究
- Molecular Biological Research of Mesothelioma
- Molecular Biological Research of Lung Cancer
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Papers (195):
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向井 智美, 佐藤 龍洋, 亀井 保博, 加藤 輝, 三城 恵美, 青木 正博, 廣島 健三, 関戸 好孝. 核と細胞質を繋ぐ核膜孔と様々な生命現象 ヌクレオポリンの翻訳後修飾異常に着目した、YAP/TAZの活性化を伴うがんに対する新規治療の可能性. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [3S04m-04]
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Tatsuhiro Sato, Ken Akao, Ayuko Sato, Tohru Tsujimura, Satomi Mukai, Yoshitaka Sekido. Aberrant expression of NPPB through YAP1 and TAZ activation in mesothelioma with Hippo pathway gene alterations. Cancer medicine. 2023. 12. 12. 13586-13598
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田中 一大, 小玉 勇太, 佐藤 龍洋, 玄 崇永, 森瀬 昌宏, 佐藤 光夫, 関戸 好孝, 石井 誠. 縦隔・胸膜疾患 オキシトシン受容体を標的とした悪性中皮腫に対する新規治療法の開発. 日本呼吸器学会誌. 2023. 12. 増刊. 187-187
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Yoshitaka Sekido, Tatsuhiro Sato. NF2 alteration in mesothelioma. Frontiers in toxicology. 2023. 5. 1161995-1161995
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Koya Suzuki, Masaki Tange, Ryota Yamagishi, Hiroyuki Hanada, Satomi Mukai, Tatsuhiro Sato, Takeshi Tanaka, Tomohiro Akashi, Kenji Kadomatsu, Tohru Maeda, et al. SMG6 regulates DNA damage and cell survival in Hippo pathway kinase LATS2-inactivated malignant mesothelioma. Cell Death Discovery. 2022. 8. 1
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MISC (330):
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向井智美, 佐藤龍洋, 三城恵美, 三城恵美, 藪田紀一, 関戸好孝. Elucidation of the mechanism of tumor progression via abnormal O-GlcNAc modification in malignant mesothelioma. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
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向井智美, 佐藤龍洋, 三城恵美, 青木正博, 藪田紀一, 関戸好孝. Elucidation of the mechanism of tumor progression via abnormal O-GlcNAc modification in malignant mesothelioma. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
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田中 一大, 佐藤 光夫, 加藤 俊夫, 後藤 大輝, 各務 智彦, 宮沢 亜矢子, 與語 直之, 長谷 哲成, 森瀬 昌宏, 関戸 好孝, et al. eIF2b is a Potential Therapeutic Target for Non-small Cell Lung Cancer(和訳中). 肺癌. 2018. 58. 6. 669-669
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佐藤 光夫, 田中 一大, 後藤 大輝, 加藤 俊夫, 各務 智彦, 宮沢 亜矢子, 與語 直之, 長谷 哲成, 森瀬 昌弘, 関戸 好孝, et al. 非小細胞肺癌に対する新規治療標的としての転写開始因子EIF2サブユニットEIF2β(The Subunit eIF2β of Translation-Initiation Factor EIF2 Is a Potential Therapeutic Target for Non-Small Cell Lung Cancer). 日本癌学会総会記事. 2018. 77回. 1819-1819
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Ichidai Tanaka, Mitsuo Sato, Toshio Kato, Daiki Goto, Tomohiko Kakumu, Ayako Miyazawa, Naoyuki Yogo, Tetsunari Hase, Masahiro Morise, Yoshitaka Sekido, et al. eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer. Cancer Science. 2018. 109. 6. 1843-1852
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Books (3):
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Cancer: Principles and Practice of Oncology, 7th edition, Sekido Y, Fong K M, Minna JD. “Molecular biology of lung cancer.” Chapter 27 p745-752 eds. Vincent T. DeVita, Jr., Samuel Hellman, Steven A. Rosenberg.
Lippincott-Williams&Wilkins 2005
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Cancer: Principles and Practice of Oncology, 6th edition, Sekido Y, Fong KM, Minna JD. “Molecular biology of lung cancer.” Chapter 31 p917-925 eds. Vincent T. DeVita, Jr., Samuel Hellman, Steven A. Rosenberg.
Lippincott-Williams&Wilkins 2001
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Textbook of Respiratory Medicine, 3rd edition, Sekido Y, Fong KM, Gazdar AF, Minna JD. Chapter 44 “Molecular biology of lung cancer” p1375-1393 eds. J. F. Murray and J.A. Nadel
W.B. Saunders Company 2000
Education (2):
- - 1992 Nagoya University
- - 1985 Nagoya University School of Medicine
Professional career (1):
Work history (6):
- 2013/08 - 現在 Aichi Cancer Center Research Institute Vice Director
- 2009/04 - 現在 Nagoya Graduate School of Medicine Division of Molecular and Cellular Oncology Affiliated professor
- 2005/04 - 現在 Aichi Cancer Center Research Institute Division of Molecular Oncology Cheif
- 1998 - 2005/03 Nagoya University Hospital Department of Clinical Preventive Medicine Assistant Professor
- 1997 - 1998 UT Southwestern Medical Center at Dallas Department of Internal Medicine Assistant Professor
- 1992 - 1997 UT Southwestern Medical Center at Dallas Hamon Center for Therapeutic Oncology Research Postdoctoral fellow
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Committee career (3):
- 2019/11 - 現在 日本肺癌学会 倫理委員会
- 2016 - 現在 日本肺癌学会 ガイドライン検討委員会胸膜中皮腫小委員会
- 2014 - 2016 日本肺癌学会 ガイドライン検討委員会胸膜中皮腫小委員会委員
Awards (1):
Association Membership(s) (12):
iMig
, IASLC
, American Association of Cancer Research
, 日本内科学会
, 日本遺伝カウンセリング学会
, 日本人類遺伝学会
, 日本分子生物学会
, 日本がん分子標的治療学会
, 日本臨床腫瘍学会
, 日本呼吸器学会
, 日本肺癌学会
, 日本癌学会
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