Suzuki Harumi

Affiliation and department：
Homepage URL (1)： http://plaza.umin.ac.jp/~suzukih/cgi-bin/lab/index.cgi

Research field (1)： Immunology

Research keywords (5)：シグナル伝達 , 分化 , T細胞 , 胸腺 , 免疫学

Research theme for competitive and other funds (24)：

2019 - 2022 Effect of novel alarmin on pathogenesis of Rheumatoid Arthrits
2010 - 2012 Function of novel molecule Gasp exclusively expressed in the thymus
2010 - 2011 正と負の選択におけるシグナル伝達機構の相違の解明
2006 - 2010 胸腺特異的遺伝子の単離と機能解析
2008 - 2009 胸腺内レパトア選択におけるRhoHの役割

2005 - 2009 Immunogenetic Analysis of Autoimmune Thyroid Diseases

2006 - 2007 Functional analysis of Th-POK in T cell development

2006 - 2007 A novelestrogen receptor in plasma membrane

2005 - 2005 LIF培養造血幹細胞を利用した新規の免疫細胞療法の開発

2004 - 2004 NK細胞によるがん細胞の排除におけるPI3キナーゼの役割

2003 - 2004 Function of Rac1 in T cell development and activation

2003 - 2004 Pax5欠損プロB細胞を用いた造血幹細胞の多分化能維持機構の解析

2001 - 2002 Functional roles of PI3 Kinase in immune system

2001 - 2002 B細胞のシグナル伝達におけるPI3キナーゼの機能

2001 - 2001 未熟胸腺細胞腫の分化誘導による増殖停止機構の解明

2000 - 2001 Evaluation of immune suppressive therapy using autoimmune model mouse

1999 - 2001 Development of immune supression against gene product in gene therapy

2000 - 2000 T細胞分化のシグナル伝達におけるPI3キナーゼの機能

2000 - 2000 血液細胞の分化におけるPI3キナーゼの役割

1999 - 2000 Study on pathophysiological mechanism of autoantibody production in pemphigus

1998 - 1999 Development of novel mouse model for autoimmune diseases using autoantigen knockout mice

1998 - 1998 NK・NKT細胞による骨髄移植片拒絶の基礎研究

1997 - 1998 T細胞の正および負の選択におけるシグナル伝達機構の解明

1992 - 1993 Preparation of ^<13>C-labeled compounds by using photosynthetic microbes and development of its sensitive detection system.

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Papers (53)：

Akihiro Kimura, Takeshi Takagi, Thiprampai Thamamongood, Satoshi Sakamoto, Takumi Ito, Iwao Seki, Masahiro Okamoto, Hiroyuki Aono, Satoshi Serada, Tetsuji Naka, et al. Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD4. Annals of the rheumatic diseases. 2023. 82. 9. 1153-1161
Kyoko Nishida-Tamehiro, Akihiro Kimura, Takeshi Tsubata, Satoru Takahashi, Harumi Suzuki. Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels. PLOS ONE. 2022. 17. 7. e0272090-e0272090
Masayuki Kitajima, Masato Kubo, Steven F Ziegler, Harumi Suzuki. Critical Role of TSLP Receptor on CD4 T Cells for Exacerbation of Skin Inflammation. Journal of immunology (Baltimore, Md. : 1950). 2020
Norimasa Tamehiro, Kyoko Nishida, Yu Sugita, Kunihiro Hayakawa, Hiroyo Oda, Takeshi Nitta, Miwa Nakano, Akiko Nishioka, Reiko Yanobu-Takanashi, Motohito Goto, et al. Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization. The Journal of allergy and clinical immunology. 2019. 143. 5. 1878-1891
Akihiro Kimura, Masayuki Kitajima, Kyoko Nishida, Satoshi Serada, Minoru Fujimoto, Tetsuji Naka, Yoshiaki Fujii-Kuriyama, Satoshi Sakamato, Takumi Ito, Hiroshi Handa, et al. NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation. The Journal of experimental medicine. 2018. 215. 8. 2197-2209

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MISC (31)：

Ryunosuke Muro, Takeshi Nitta, Harumi Suzuki, Hiroshi Takayanagi. Deciphering lineage-specific TCR signaling in IL-17-producing gamma delta T cell development. CYTOKINE. 2017. 100. 129-129
Akihiro Kimura, Masayuki Kitajima, Harumi Suzuki. The novel ubiquitin ligase complex, NQO1-PDLIM2 inhibits TLR-dependent production of selective cytokines by degrading I kappa B-zeta. CYTOKINE. 2017. 100. 147-148
Masayuki Kitajima, Akihiro Kimura, Harumi Suzuki. Irritant contact dermatitis is regulated by antioxidative enzyme NAD(P)H:quinone oxidoreductase (Nqol). JOURNAL OF IMMUNOLOGY. 2016. 196
Norimasa Tamehiro, Hiroyo Oda, Harumi Suzuki. Post-translational regulation of RhoH via the proteasomal pathway. JOURNAL OF IMMUNOLOGY. 2012. 188
PATRICK Michael S, ODA Hiroyo, HAYAKAWA Kunihiro, SATO Yoshinori, ESHIMA Koji, SHIRAI Mutsunori, SUZUKI Harumi. A novel Grb2 associating protein Gasp is critically required for positive selection of thymocytes. 日本免疫学会総会・学術集会記録. 2009. 39. 77

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Education (2)：

- 1998 東京大学大学院農学研究科農芸化学専攻
- 1993 The University of Tokyo

Professional career (1)：

農学博士 (東京大学)

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