Okamura Emiko

オカムラエミコ | Okamura Emiko

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://www.himeji-du.ac.jp/faculty/f_lab/bpc/index.html , https://www.himeji-du.ac.jp/faculty/f_lab/bpc/en/index.html

Research field (3)： Basic physical chemistry , Biochemistry , Pharmaceuticals - analytical and physicochemistry

Research keywords (20)： Membrane dynamics , 拡散 , 生物物理 , パルス磁場勾配NMR , 熱揺らぎ , 動態 , 内分泌撹乱物質 , リン脂質二分子膜 , 膜輸送 , 超精密計測 , 表面・界面物性 , 赤外反射吸収スペクトル , Lipid bilayer membrane , NMR・赤外分光 , ドラッグデリバリー , 生物物理化学 , Biophysical Chemistry , NMR , Membrane , Drug Delivery

Research theme for competitive and other funds (28)：

2022 - 2025 創薬を指向したペプチドの動態制御:リアルタイムNMRによる膜透過とアミロイド形成
2019 - 2022 Dynamics in polypeptides and its regulation: Cell transport and amyloid formation
2015 - 2019 Quantitative Analysis of Drug Deliveries to Living Cells by Real-Time In-Cell NMR Spectroscopy
2013 - 2017 Physicochemical mechanism on formation and metabolism of HDL particles by apolipoproteins
2012 - 2015 Multinuclear Dynamic NMR of Diffusion and Transport of Polypeptides by Membrane Thermal Fluctuation

2013 - 2014 The Quantitative In-Cell NMR Observation of Drug Transport into Living Cells to Establish its Prediction Model

2011 - 2013 Restricted diffusion of lipid molecules on the vesicle surface studied by NMR measurement and Monte Carlo calculation

2009 - 2011 Multinuclear dynamic NMR of drug transport relating to the fluctuation of biomembranes

2009 - 2011 生体膜の揺らぎによる薬物の輸送機構の動的多核NMR解析

2008 - 2011 膜の熱揺らぎとドラッグデリバリーに関する動的多核NMR解析

2008 - 2011 Multinuclear, Dynamic NMR of Membrane Thermal Fluctuation and Drug Deliveries

2009 - 2010 In-cell NMR spectroscopy of drugs: noninvasive detection and transport mechanism

2009 - 2010 薬物のin-cell NMR:シグナルの非侵集検出と輸送解析

2006 - 2008 Dynamic and Multinuclear NMR Studies of Molecular Transport and Distribution in Biomembrane

2005 - 2007 高感度高分解能NMRによる脂質ラフトの動態解析

2005 - 2007 Molecular Dynamics in Lipid Rafts by High-Sensitivity, High-Resolution NMR

2003 - 2005 Development of multinuclear, high-temperature, and diffusion NMR probe and dynamics of supercritical aqueous solutions

2002 - 2004 NMRによるリン脂質二分子膜中の内分泌撹乱物質の輸送解析

2002 - 2004 Membrane Transport of Endocrine Disruptors by Static and Dynamic NMR

2004 - 2004 熱揺らぎに基づくリン脂質二分子膜中のイオンの輸送機構

2001 - 2002 Mechanisms of Noncatalytic Organic Chemical Reactions in Super- and Subcritical Water

1998 - 2000 Aqueous Solution Chemistry at Supercritical Conditions

1989 - 1992 発色団を含む非対称LB膜の構造と機能の相関解析

1991 - 1991 発色団を含む非対称LB膜の構造と機能の相関解折

1990 - 1990 発色団を含む非対称LB膜の構造と機能の相関解析

1989 - 1989 発色団を含む非対称LB膜の構造と機能の相関解析

高感度高分解能NMRによる細胞およびモデル膜へのドラッグデリバリーと膜中薬物の存在状態の研究

High-Sensitivity, High-Resolution NMR Study of Drug Delivery into Model and Cell Membranes

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Papers (85)：

Kenzo Aki, Emiko Okamura. Side-chain conformers to allow conversion from normal to isoaspartate in age-related proteins and peptides. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 2020. 1868. 11. 140483-140483
Emiko Okamura, Kenzo Aki. Real-time in-situ 1H NMR of reactions in peptide solution: preaggregation of amyloid-β fragments prior to fibril formation. Pure and Applied Chemistry. 2020
K. Aki, E. Okamura. Isomerization of aspartyl residue in amyloid beta fragments: The kinetics by real-time 1H NMR under neutral and basic conditions. J. Soln. Chem. 2020
E. Okamura. Solution NMR to Quantify Mobility in Membranes: Diffusion, Protrusion, and Drug Transport Processes. Chem. Pharm. Bull. 2019. 67. 308-315
Y. Takechi-Haraya, K. Aki, Y. Tohyama, Y. Harano, T. Kawakami, H. Saito, E. Okamura. Glycosaminoglycan Binding and Non-Endocytic Membrane Translocation of Cell-Permeable Octaarginine Monitored by Real-Time In-Cell NMR Spectroscopy. Pharmaceuticals. 2017. 10. 42

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MISC (18)：

YOSHII Noriyuki, OKAMURA Emiko. Mobility of Drugs in Lipid Membranes by NMR. Oleoscience. 2011. 11. 6. 213-220
YOSHII Noriyuki, OKAMURA Emiko. NMR Study of Drug Permeation Related to the Fluctuation of Soft Lipid Membranes. Membrane. 2011. 36. 1. 9-15
吉井範行, 岡村恵美子. NMRによる脂質膜中の薬物の「運動」の解析. オレオサイエンス. 2011. 11. 6. 213-220
YOSHII Noriyuki, OKAMURA Emiko. NMR Study of Drug Permeation Related to the Fluctuation of Soft Lipid Membranes. MEMBRANE. 2011. 36. 1. 9-15
岡村恵美子. 高分解能溶液NMRによる薬物の膜への結合と膜のなかのダイナミクス. 分子シミュレーション研究会会誌「アンサンブル」. 2009. 11. 4 (通巻48号). 18-21

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Books (4)：

NMR OF DRUG DELIVERY COUPLED WITH LIPID MEMBRANE DYNAMICS
Encyclopedia of Biocolloid and Biointerface Science, Volume 1, John Wiley & Sons, Inc 2016
Fluctuation, Dynamics, and Function-Dojin Bioscience Series 10
Kagakudojin 2013
NMR Studies on Lipid Bilayer Interfaces Coupled with Anesthetics and Endocrine Disruptors (Chapter 32), (共著)
Liquid Interfaces in Chemical, Biological, and Pharmaceutical Applications, Marcel Dekker 2001
NMR Studies on Lipid Bilayer Interfaces Coupled with Anesthetics and Endocrine Disruptors (Chapter 32)
Liquid Interfaces in Chemical, Biological, and Pharmaceutical Applications, Marcel Dekker 2001

Education (3)：

1982 - 1983 Kyoto University Graduate School of Pharmaceutical Sciences Doctor Course
1980 - 1982 Kyoto University Gracuate School of Pharmaceutical Sciences Master Course
1976 - 1980 Kyoto University Faculty of Pharmaceutical Sciences

Professional career (2)：

Doctor of Pharmaceutical Science (Kyoto University)
Master of Pharmaceutical Science (Kyoto University)

Work history (4)：

2007/04 - 現在 Himeji Dokkyo University Faculty of Pharmaceutical Sciences Professor
2006/10 - 2007/03 Kyoto University Institute for Chemical Research Associate Professor
2001/07 - 2006/09 Kyoto University Institute for Chemical Research Assistant Professor
1983/02 - 2001/06 Kyoto University Institute for Chemical Research Research Associate

Committee career (16)：

2019/05 - 現在 The Membrane Society of Japan Vice-President
2014 - 現在日本油化学会代議員
2013/04 - 現在 Japan Oil Chemists' Society Kansai Branch, Manager
2013/04 - 現在日本油化学会関西支部幹事
2012/03 - 現在 The Chemical Society of Japan The Division of Colloid and Surface Chemistry, Kansai Branch, Director

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Awards (4)：

2016/05 - The Membrane Society of Japan 2015 the Best Paper in Membrane Regulation of Phospholipid Protrusion in the Cell Sized Vesicle by Hydrophobic Bisphenol A
2012 - The Japan Oil Chemists Society Oleoscience Editor's Award
2009 - 第2回資生堂女性研究者サイエンスグラント
2009 - The Shiseido Female Researcher Science Grant

Association Membership(s) (19)：

JAPAN OIL CHEMISTS' SOCIETY , American Chemical Society , Biophysical Society , 日本生物物理学会 , 麻酔メカニズム研究会 , 溶液化学研究会 , 日本膜学会 , 日本薬学会 , 同コロイドおよび界面化学部会 , 日本化学会 , American Chemical Society , Biophysical Society , The Biophysical Society of Japan , Research Group of Anesthetic Mechanism in Japan , The Japan Association of Solution Chemistry , The Membrane Society of Japan , The Pharmaceutical Society of Japan , The Division of Colloid and Surface Chemistry , The Chemical Society of Japan

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