Art

J-GLOBAL ID：201802233496471866   Reference number：18A1241621

Glycosaminoglycan Binding and Non-Endocytic Membrane Translocation of Cell-Permeable Octaarginine Monitored by Real-Time In-Cell NMR Spectroscopy

実時間細胞内NMR分光法によりモニターした細胞透過性オクタアルギニンのグリコサミノグリカン結合と非エンドサイトーシス膜転座【JST・京大機械翻訳】

Author (7)： Takechi-Haraya Yuki (Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kamiohno, Himeji 670-8524, Japan) ,  Aki Kenzo (Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kamiohno, Himeji 670-8524, Japan) ,  Tohyama Yumi (Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kamiohno, Himeji 670-8524, Japan) ,  Harano Yuichi (Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kamiohno, Himeji 670-8524, Japan) ,  Kawakami Toru (Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Saito Hiroyuki (Department of Biophysical Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan) ,  Okamura Emiko (Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kamiohno, Himeji 670-8524, Japan)
Material： Pharmaceuticals (Web)
Volume： 10  Issue： 2  Page： 42  Publication year： 2017 
JST Material Number： U7257A  ISSN： 1424-8247  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Glycosaminoglycans (GAGs), whi...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A1241621&from=J-GLOBAL&jstjournalNo=U7257A") }}

Thesaurus term： *translocation (genetics) ,  quantitative analysis ,  *glycosaminoglycan ,  *NMR ,  human ,  covalent bond ,  Cell Membrane ,  *Endocytosis ,  Osmosis ,  Membrane Proteins ,  Cytosol ,  live cell ,  cell surface ,  *octaarginine ,  *cellular genetic phenomenon ,  Endomembrane system ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  primary amine

Author keywords (6)： glycosaminoglycan ,  heparin ,  cell penetrating peptide ,  octaarginine ,  non-endocytic membrane translocation ,  in-cell nuclear magnetic resonance spectroscopy

JST classification (2)： Transport of cell membrane  (EF04020R) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Arginine

Reference (73)：

• Trabulo, S.; Cardoso, A.L.; Mano, M.; de Lima, M.C.P. Cell-penetrating peptides-mechanisms of cellular uptake and generation of delivery systems. Pharmaceuticals 2010, 3, 961-993.
• Keller, A.A.; Mussbach, F.; Breitling, R.; Hemmerich, P.; Schaefer, B.; Lorkowski, S.; Reissmann, S. Relationships between cargo, cell penetrating peptides and cell type for uptake of non-covalent complexes into live cells. Pharmaceuticals 2013, 6, 184-203.
• Howl, J.; Matou-Nasri, S.; West, D.C.; Farquhar, M.; Slaninová, J.; Östenson, C.G.; Zorko, M.; Östlund, P.; Kumar, S.; Langel, Ü.; et al. Bioportide: An emergent concept of bioactive cell-penetrating peptides. Cell. Mol. Life Sci. 2012, 69, 2951-2966.
• Liu, B.R.; Lin, M.D.; Chiang, H.J.; Lee, H.; Revon, B. Arginine-rich cell-penetrating peptides deliver gene into living human cells. Gene 2012, 505, 37-45.
• Jones, A.T.; Sayers, E.J. Cell entry of cell penetrating peptides and tales of tails wagging dogs. J. Control. Release 2012, 161, 582-591.

Terms in the title (10)： 実時間 ,  細胞内NMR ,  分光法 ,  モニター ,  細胞 ,  透過性 ,  オクタアルギニン ,  グリコサミノグリカン ,  エンドサイトーシス ,  転座