Fujii Ryoji

フジイリョウジ | Fujii Ryoji

Affiliation and department：
Job title： Associate Professor
Other affiliations (1)：

聖マリアンナ医科大学難病治療研究センター実験動物研究施設実験動物研究施設長

Research field (1)： Molecular biology

Research keywords (3)： rheumatoid arthritis , 遺伝情報発現・制御 , Mechanisms of Gene Regulation

Research theme for competitive and other funds (8)：

2021 - 2024 難治性SPACIA1依存的関節リウマチのバイオマーカー探索と薬剤標的の検討
2020 - 2023 機械的ストレスに応答する軟骨の核酸修復とエネルギー代謝の相関解析、治療法への応用
2013 - 2017 Potential of SPACIA1 as a druggable target of rheumatoid arthritis
2010 - 2012 Study of novel factor, SPACIA1 which is expressed in synovial tissue in rheumatoid arthritis.
2002 - 2002 翻訳反応におけるRNAヘリケースA/ウイルスmRNA複合体の生物学的意義の解明

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Papers (38)：

藤井亮爾, 小松梨恵, 仁木久照, 遊道和雄. 関節リウマチ由来滑膜線維芽細胞において炎症性サイトカインで誘導される細胞周期因子cyclin-dependent kinase 6. 聖マリアンナ医科大学雑誌. 2019. 46. 4. 239-247
Takanori Kumai, Naoko Yui, Kanaka Yatabe, Chizuko Sasaki, Ryoji Fujii, Mitsuko Takenaga, Hiroto Fujiya, Hisateru Niki, Kazuo Yudoh. A novel, self-assembled artificial cartilage-hydroxyapatite conjugate for combined articular cartilage and subchondral bone repair: histopathological analysis of cartilage tissue engineering in rat knee joints. International journal of nanomedicine. 2019. 14. 1283-1298
Fujii R, Komatsu R, Sato T, Seki I, Konomi K, Aono H, Niki H, Yudoh K, Nishioka K, Nakajima T. SPACIA1/SAAL1 Deletion Results in a Moderate Delay in Collagen-Induced Arthritis Activity, along with mRNA Decay of Cyclin-dependent Kinase 6 Gene. International journal of molecular sciences. 2018. 19. 12
Hidetoshi Fujita, Satoko Aratani, Ryouji Fujii, Yoshihisa Yamano, Naoko Yagishita, Natsumi Araya, Toshihiko Izumi, Kazuko Azakami, Daisuke Hasegawa, Kusuki Nishioka, et al. Mitochondrial ubiquitin ligase activator of NF-B regulates NF-B signaling in cells subjected to ER stress. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2016. 37. 6. 1611-1618
Ryoji Fujii, Iwao Seki, Rie Komatsu, Tomomi Kohara, Miwa Takai, Tomoo Sato, Koji Konomi, Hiroyuki Aono, Kazuo Yudoh, Kusuki Nishioka, et al. SPACIA1/SAAL1-Deficient Mice Show Reduced Disease Progression in Collagen-Induced Arthritis. ARTHRITIS & RHEUMATOLOGY. 2015. 67

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MISC (4)：

長谷川大輔, 藤井亮爾, 八木下尚子, 松本伸行, 荒谷聡子, 佐藤知雄, 新谷奈津美, 小池淳樹, 田所衛, 鈴木登, et al. E3 Ubiquitin Ligase Synoviolinは肝線維症に関与する(E3 Ubiquitin Ligase Synoviolin Is Involved in Liver Fibrogenesis). 聖マリアンナ医科大学雑誌. 2012. 39. 4. 293-293
Hasegawa D, Fujii R, Yagishita N, Matsumoto N, Aratani S, Izumi T, Azakami K, Nakazawa M, Fujita H, Sato T, et al. Posttranslational Regulation of Collagen Expression in Liver Fibrosis by the E3 Ubiquitin Ligase Synoviolin. PLoS One. 2010. 5. 10. e13590
荒谷聡子, 藤井亮爾, 藤田英俊, 中島利博. HIV遺伝子発現に関与する宿主システムの解明. 臨床薬理の進歩. 2004. 25. 120-125
N van Trieu, R Fujii, K Nishioka, T Nakajima. Molecular mechanism of notch1 activation in synoviocytes from osteoarthritis and rheumatoid arthritis patients. ARTHRITIS AND RHEUMATISM. 2002. 46. 9. S259-S259

Patents (1)：

慢性関節リウマチ治療剤

Books (6)：

フードスタイル21
フードスタイル21 2018
希少疾患用医薬品の適応拡大と事業性評価
技術情報協会 2018
医学のための細胞生物学
南山堂 2009
Vascular Biology ナビゲーター
株)メディカルレビュー社 2001
Coactivator
2001

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Education (4)：

1998 - 2001 University of Tsukuba
- 2001 University of Tsukuba Graduate School, Division of Agriculture
1991 - 1993 University of Tsukuba
1987 - 1991 University of Tsukuba

Professional career (1)：

Ph.D (University of Tsukuba)

Work history (10)：

2019 - 現在 St.Marianna University School of Medicine
2005 - 2019 St.Marianna University School of Medicine
2003 - 2005 The Burnham Institute, CA, USA Postdoctoral fellow
2001 - 2005 St.Marianna University School of Medicine
2001 - 2005 St.Marianna University School of Medicine,

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Association Membership(s) (3)：

日本リウマチ学会 , 日本分子生物学会 , The Molecular Biology Society of Japan

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