Imagawa Hiroshi

Affiliation and department：
Job title： Instructor
Homepage URL (1)： http://p.bunri-u.ac.jp/lab04/

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (2)：有機合成化学 , Organic Synthesis

Research theme for competitive and other funds (19)：

2021 - 2024 Total synthesis of (+)-spirotenuipesine A and repair of nerve function by dual activation
2014 - 2016 分岐型DNA合成を基盤とするDNAカプセルおよびDNAシートの創製
2011 - 2014 Study of the mechanism of action of Neobivsanin derivatives:Toward development of anti-Alzheimer's disease drugs
2008 - 2011 抗痴呆薬の開発を目指したネオビブサニン類及びネオビブサニン関連化合物の合成研究
2005 - 2008 神経突起伸展活性を持つビブサニン類及びフラノビブサニン類の合成研究

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Papers (123)：

Abdelsamed I Elshamy, Tarik A Mohamed, Tatsuro Yoneyama, Masaaki Noji, Sayaka Ban, Hiroshi Imagawa, Thomas Efferth, Mohamed-Elamir F Hegazy, Akemi Umeyama. Bifusicoumarins A-D: Cytotoxic 3S-dihydroisocoumarins from the entomopathogenic fungus Cordyceps bifusispora (NBRC 108997). Phytochemistry. 2023. 212. 113743-113743
Tatsuro Yoneyama, Abdelsamed I. Elshamy, Junpei Yamada, Walaa A. El-Kashak, Yusuke Kasai, Hiroshi Imagawa, Sayaka Ban, Masaaki Noji, Akemi Umeyama. Antimicrobial metabolite of Cordyceps tenuipes targeting MurE ligase and histidine kinase via in silico study. Applied Microbiology and Biotechnology. 2022
Yuki Kimura, Eisaku Ohashi, Sangita Karanjit, Takashi Taniguchi, Atsushi Nakayama, Hiroshi Imagawa, Ryota Sato, Kosuke Namba. Total Syntheses of Proposed Structures of 4,10-Dihydroxy-8,12-guaianolides. Organic Letters. 2022. 24. 17. 3297-3301
Yusuke Kasai, Takamitsu Ogawa, Mao Kawata, Kana Tanigawa, Abdelsamed I. Elshamy, Tatsuro Yoneyama, Masaaki Noji, Akemi Umeyama, Hiroshi Imagawa. Short-step Synthesis of Cordytakaoamide B and Cordycepamide C via Intramolecular Regioselective Oxidation-Lactone Formation. Natural Product Communications. 2022
Tsuyoshi Yanagimoto, Sayo Yamada, Yusuke Kasai, Hirofumi Yamamoto, Miwa Kubo, Yoshiyasu Fukuyama, Hiroshi Imagawa. Total synthesis of (±)-spirotenuipesine A, a promoter of neurotrophic factor secretion from glial cells. Tetrahedron Letters. 2021. 64

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MISC (302)：

西岡佑介, 米山達朗, 杉本友美, 柳本剛志, 新居慎也, 井下美咲, 金城茜, 中村由佳里, 葛西祐介, 野路征昭, et al. Synthesis of cyclic peptides using the property of long-chain protecting group and their application to the structure determination of Heteropodamide C. 日本薬学会年会要旨集(Web). 2022. 142nd
大城彩里, 住友健人, 山崎直人, 江角朋之, 兼目裕充, 浅川義範, 葛西祐介, 今川洋, 葛原隆, 山本博文. The Synthesis of FG-beads linked Thallusin. 日本薬学会年会要旨集(Web). 2021. 141st
柳本剛志, 山田紗世, 葛西祐介, 山本博文, 今川洋. Synthesis and biological evaluation of spirotenuipesine A derivatives. 日本薬学会年会要旨集(Web). 2021. 141st
小川貴充, 谷川佳那, ELSHAMY Abdelsamed, 大城彩里, 葛西祐介, 米山達朗, 野路征昭, 山本博文, 伴さやか, 梅山明美, et al. Total synthesis and determination of the absolute configuration of cordytakaoamide B. 日本薬学会年会要旨集(Web). 2021. 141st
山上真央, 佐川友梨, 高木宝暉, 葛西祐介, 山本博文, 今川洋. Exploration of acyl N-(methoxymethyl)sulfonamides as activated esters for derivatization of carboxylic acids. 日本薬学会年会要旨集(Web). 2021. 141st

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Patents (13)：

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Books (1)：

日本発ブロックバスターを目指して : 創薬研究の最前線 = Highlights of the Japanese blockbuster drugs and related technologies
シーエムシー出版 2010 ISBN:9784781302454

Lectures and oral presentations (5)：

Total synthesis of (±)-Oridamycin A
(International Symposium on Natural Products for the Future 2016 Tokushima 2016)
Syntheses of a Series of Thallsin Analogues and their Growth Promoting Activity for Green Macroalgae
(International Symposium on Natural Products for the Future 2016 Tokushima 2016)
Design and Synthesis of Novel Neovibsanin Derivatives Based on a Chemical Structure Hybridization Method
(International Symposium on Natural Products for the Future 2016 Tokushima 2016)
神経変性疾患治療のための新しい分子標的の探索
(創薬シンポジウム徳島文理大学 2016 2016)
Syntheses of Structurally-simplified Neovibsanin Derivatives and Analysis of their Neurite Outgrowth Activity
(23rd French-Japanese Symposium on medicinal and fine chemistry 2013)

Education (4)：

- 1995 Tokushima Bunri University Faculty of Pharmaceutical Sciences
- 1995 Tokushima Bunri University Graduate School, Division of Pharmaceutical Sciences
- 1990 Tokushima Bunri University Faculty of Pharmaceutical Sciences Department of Pharmaceutics
- 1990 Tokushima Bunri University Faculty of Pharmaceutical Science

Professional career (1)：

Work history (3)：

Committee career (3)：

Awards (1)：

Association Membership(s) (4)：

アメリカ化学会 , 有機合成化学協会 , 日本化学会 , 日本薬学会

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