Uesaka Toshihiro

ウエサカトシヒロ | Uesaka Toshihiro

Affiliation and department：
Job title： Associate Professor

Research field (1)： Neuroanatomy and physiology

Research theme for competitive and other funds (12)：

2021 - 2024 シュワン細胞による腸管神経系の再形成の誘導
2017 - 2019 腸管神経系の組織恒常性維持機構の解明
2016 - 2019 RETチロシンキナーゼの活性化レベル変動と神経系形成異常の相関についての検証
2017 - 神経芽腫に対する新規治療剤の探索
2010 - 2015 Vascular tissues that supports migration of enteric neural progenitors

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Papers (25)：

Mukhamad Sunardi, Keisuke Ito, Yuya Sato, Toshihiro Uesaka, Mitsuhiro Iwasaki, Hideki Enomoto. A single RET mutation in Hirschsprung disease induces intestinal aganglionosis via a dominant-negative mechanism. Cellular and Molecular Gastroenterology and Hepatology. 2022. 15. 6. 1505-1524
Yuta Yoshioka, Yoshihisa Tachibana, Toshihiro Uesaka, Hiroyuki Hioki, Yuya Sato, Takumi Fukumoto, Hideki Enomoto. Uts2b is a microbiota-regulated gene expressed in vagal afferent neurons connected to enteroendocrine cells producing cholecystokinin. Biochemical and biophysical research communications. 2022. 608. 66-72
Toshihiro Uesaka, Mitsumasa Okamoto, Mayumi Nagashimada, Yoshihiro Tsuda, Miho Kihara, Hiroshi Kiyonari, Hideki Enomoto. Enhanced enteric neurogenesis by Schwann cell precursors in mouse models of Hirschsprung disease. Glia. 2021. 69. 11. 2575-2590
Taichi Nakatani, Mitsuhiro Iwasaki, Atsuhiro Yamamichi, Yuta Yoshioka, Toshihiro Uesaka, Yuko Bitoh, Kosaku Maeda, Takumi Fukumoto, Tatsuya Takemoto, Hideki Enomoto. Point mutagenesis in mouse reveals contrasting pathogenetic effects between MEN2B- and Hirschsprung disease-associated missense mutations of the RET gene. Development, growth & differentiation. 2020. 62. 4. 214-222
Mitsumasa Okamoto, Yuta Yoshioka, Kosaku Maeda, Yuko Bito, Takumi Fukumoto, Toshihiro Uesaka, Hideki Enomoto. Mice conditionally expressing RET(C618F) mutation display C cell hyperplasia and hyperganglionosis of the enteric nervous system. Genesis (New York, N.Y. : 2000). 2019. 57. 5. e23292

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MISC (20)：

Toshihiro Uesaka, Heather M. Young, Vassilis Pachnis, Hideki Enomoto. Development of the intrinsic and extrinsic innervation of the gut. DEVELOPMENTAL BIOLOGY. 2016. 417. 2. 158-167
Toshihiro Uesaka, Hideki Enomoto. Glial cell line-derived neurotrophic factor is a key regulator for the migration of enteric neural crest derivatives. NEUROSCIENCE RESEARCH. 2011. 71. E66-E67
Toshihiro Uesaka, Hideki Enomoto. Bcl-xL-mediated rescue of aganglionosis in a mouse model for Hirschsprung disease. NEUROSCIENCE RESEARCH. 2009. 65. S66-S67
Toshihiro Uesaka, Hideki Enomoto. Multiple roles of GDNF signaling in development of the enteric nervous system. NEUROSCIENCE RESEARCH. 2008. 61. S40-S40
T Uesaka, N Kageyama. Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. FEBS LETTERS. 2004. 573. 1-3. 147-154

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Books (1)：

Physiology of the Gastrointestinal Tract / Development of the Enteric Nervous System
Academic Press 2018

Lectures and oral presentations (16)：

腸管神経系の形成不全後のシュワン細胞系譜からの腸管ニューロン産生
(第124回日本解剖学会総会・全国学術集会 2019)
腸管神経系の形成不全後のシュワン細胞系譜からの腸管ニューロン産生
(CSMIリトリート「若手道場」 2019)
RET 活性化型変異 C618F は遺伝子量減少によりヒルシュスプルング病を誘導する
(CSMIリトリート「若手道場」 2019)
Formation of enteric nervous system from Schwann cell precursors in mouse models of Hirschsprung disease
(第2回神戸理研・神戸大学合同シンポジウム 2019)
腸管神経系形成不全下におけるシュワン細胞系譜からのニューロン産生
(第94回日本解剖学会近畿支部学術集会 2018)

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Works (1)：

黎明研究「遺伝子導入による小腸放射線障害の軽減効果の検証」
2003 -

Professional career (2)：

PhD
博士(学術) (広島大学)

Association Membership(s) (3)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS , THE JAPAN NEUROSCIENCE SOCIETY

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