Rchr
J-GLOBAL ID：200901049472240215
Update date: Jan. 30, 2024
Osumi Kenji
Osumi Kenji
Affiliation and department：
Job title：
Researcher
Research field (1)：
Synthetic organic chemistry
Research keywords (4)：
transglycosylation
, 合成
, オリゴ糖
, antibody-drug conjugates
Research theme for competitive and other funds (3)：
- 2012 - 2016 Development of anti-saccharide antibody screening system using glycosylated silsesquioxane probe.
- 2011 - 2013 筋ジストロフィーの治療法開発を目指した発症メカニズムの解明研究
- 2010 - 2012 Studies on the function utilization of sialic acid-containing Oligosaccharides peptide
Papers (29)：
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Shou Takashima, Masaki Kurogochi, Wataru Tsukimura, Masako Mori, Kenji Osumi, Shu-Ichi Sugawara, Junko Amano, Mamoru Mizuno, Yoshio Takada, Akio Matsuda. Preparation and biological activities of anti-HER2 monoclonal antibodies with multi-branched complex-type N-glycans. Glycobiology. 2021
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Shou Takashima, Masaki Kurogochi, Kenji Osumi, Shu-Ichi Sugawara, Mamoru Mizuno, Yoshio Takada, Junko Amano, Akio Matsuda. Novel endo-β-N-acetylglucosaminidases from Tannerella species hydrolyze multibranched complex-type N-glycans with different specificities. Glycobiology. 2020. 30. 11. 923-934
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Michihiko Aoyama, Noritaka Hashii, Wataru Tsukimura, Kenji Osumi, Akira Harazono, Minoru Tada, Masato Kiyoshi, Akio Matsuda, Akiko Ishii-Watabe. Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies. mAbs. 2019. 11. 5. 826-836
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Rieko Imae, Hiroshi Manya, Hiroki Tsumoto, Kenji Osumi, Tomohiro Tanaka, Mamoru Mizuno, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Toda, Tamao Endo. CDP-glycerol inhibits the synthesis of the functional O-mannosyl glycan of α-dystroglycan. The Journal of biological chemistry. 2018. 293. 31. 12186-12198
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Wataru Tsukimura, Masaki Kurogochi, Masako Mori, Kenji Osumi, Akio Matsuda, Kaoru Takegawa, Kiyoshi Furukawa, Takashi Shirai. Preparation and biological activities of anti-HER2 monoclonal antibodies with fully core-fucosylated homogeneous bi-antennary complex-type glycans. Bioscience, Biotechnology and Biochemistry. 2017. 81. 12. 2353-2359
ｍore...
MISC (27)：
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高島晶, 大隅賢二, 黒河内政樹, 水野真盛, 高田美生, 松田昭生. Transglycosylation of G3a type tri-antennary complex type N-glycan to antibody by glycosynthases. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
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高島晶, 黒河内政樹, 大隅賢二, 菅原州一, 水野真盛, 天野純子, 高田美生, 松田昭生. Analysis of ENGases containing T9SS C-terminal target domain. 日本糖質学会年会要旨集. 2020. 39th
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田中智博, 大隅賢二, 白石美香, 杉原礼子, 松田昭生, 水野真盛. 直交性保護基を利用した二ヶ所に異なる糖鎖を有する糖ペプチドの化学酵素合成. 日本薬学会年会要旨集(CD-ROM). 2019. 139th
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田中智博, 大隅賢二, 松田昭生, 水野真盛. 糖たんぱく質医薬品の化学合成を指向した複数の糖鎖を有する糖ペプチドの化学酵素合成. メディシナルケミストリーシンポジウム講演要旨集. 2019. 37th
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高島晶, 黒河内政樹, 月村亘, 大隅賢二, 森昌子, 天野純子, 水野真盛, 高田美生, 松田昭生. 多分岐糖鎖をもつ抗体の調製. 日本生化学会大会(Web). 2019. 92nd
ｍore...
Patents (21)：
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7糖オリゴ糖の製造方法
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糖アミノ酸誘導体または糖ペプチド誘導体の製造方法
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糖ペプチド誘導体及びその製造方法
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糖ペプチド結合ポリマー
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血管内皮細胞の管腔形成抑制剤
ｍore...
Professional career (2)：
- (BLANK) (Meiji University)
- Doctor (Tokyo Institute of Technology)
Association Membership(s) (1)：
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