Rchr

J-GLOBAL ID：200901054259536740 Update date: Feb. 14, 2024

Osada Hirotaka

オサダヒロタカ | Osada Hirotaka

Affiliation and department：
Job title： Section Head

Research field (1)： Pathobiochemistry

Research keywords (8)：エピジェネティック異常 , 遺伝子治療 , 神経内分泌分化 , がん抑制遺伝子 , がん遺伝子 , 肺癌 , leukemia/lymphoma , lung cancer

Research theme for competitive and other funds (8)：

2004 - 神経内分泌肺癌の発症・進展の分子機序
2003 - RNAiを用いた癌分子標的治療の検討
2002 - 肺癌におけるクロマチン構造異常・エピジェネティック異常の解析と臨床応用
肺癌の治療標的分子の検討
Roles of ASH1/ASCL1 in development of lung neuroendocrine tumors

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Papers (7)：

I. Tanaka, H. Osada, M. Fujii, A. Fukatsu, T. Hida, Y. Horio, Y. Kondo, A. Sato, Y. Hasegawa, T. Tsujimura, et al. LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade. ONCOGENE. 2015. 34. 1. 73-83
Lynnette Fernandez-Cuesta, Dennis Plenker, Hirotaka Osada, Ruping Sun, Roopika Menon, Frauke Leenders, Sandra Ortiz-Cuaran, Martin Peifer, Marc Bos, Juliane Dassler, et al. CD74-NRG1 Fusions in Lung Adenocarcinoma. CANCER DISCOVERY. 2014. 4. 4. 415-422
T. Mizuno, H. Murakami, M. Fujii, F. Ishiguro, I. Tanaka, Y. Kondo, S. Akatsuka, S. Toyokuni, K. Yokoi, H. Osada, et al. YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. ONCOGENE. 2012. 31. 49. 5117-5122
Tomoya Yamaguchi, Kiyoshi Yanagisawa, Ryoji Sugiyama, Yasuyuki Hosono, Yukako Shimada, Chinatsu Arima, Seiichi Kato, Shuta Tomida, Motoshi Suzuki, Hirotaka Osada, et al. NKX2-1/TITF1/TTF-1-Induced ROR1 Is Required to Sustain EGFR Survival Signaling in Lung Adenocarcinoma. CANCER CELL. 2012. 21. 3. 348-361
Eri Nishikawa, Hirotaka Osada, Yasumasa Okazaki, Chinatsu Arima, Shuta Tomida, Yoshio Tatematsu, Ayumu Taguchi, Yukako Shimada, Kiyoshi Yanagisawa, Yasushi Yatabe, et al. miR-375 Is Activated by ASH1 and Inhibits YAP1 in a Lineage-Dependent Manner in Lung Cancer. CANCER RESEARCH. 2011. 71. 19. 6165-6173

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MISC (134)：

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Education (4)：

- 1988 Nagoya University
- 1982 Nagoya University School of Medicine
Nagoya University, School of Medicine
Nagoya University Graduate School of Medical Science

Professional career (1)：

M.D.,Ph.D.

Work history (33)：

2000/04 - - 愛知県がんセンター研究所分子腫瘍学部室長
2000/04 - -; Section Head, Division of Molecular
1997/04 - 2000/03 愛知がんセンター研究所病態学研究室室長
1997/04 - 2000/03 ; Section Head, Pathophysiology Unit.
1996/04 - 1997/03 愛知がんセンター研究所超微形態学部室長

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Association Membership(s) (5)：

米国癌学会 , 日本分子生物学会 , 日本癌学会 , The Molecular Biology Society of Japan , The Japanese Cancer Association

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