Higuchi Kazuhiro

ヒグチカズヒロ | Higuchi Kazuhiro

Affiliation and department：
Homepage URL (1)： https://u-lab.my-pharm.ac.jp/~knbskg/index.html

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (1)： Synthesis of natural compound

Research theme for competitive and other funds (5)：

2022 - 2027 Study of the use of sulfur (IV) atom: Synthesis and reaction of alkylsulfonium salts
2016 - 2019 チオニウムを用いたアリールカップリング反応の開発と縮合型複素環骨格への展開
2009 - 2011 マンニッヒ型反応による、新規2、2-ジ置換インドリン-3-オンの合成とその展開
2007 - 2009 血小板凝集阻害作用を目指した、低分子偽ペプチド化合物の合成研究
2002 - 2004 ピロロカルバゾール構造を鍵シントンとするインドールアルカロイドの合成研究

Papers (48)：

Kazuhiro Higuchi, Kazunori Matsumura, Takafumi Arai, Motoki Ito, Shigeo Sugiyama. Intramolecular Aminolactonization for Synthesis of Furoindolin-2-One. Molecules. 2021. 27. 1. 102-102
Motoki Ito, Shigeo Sugiyama, Mamiko Mori, Tomoya Nakagawa, Miki Hori, Kazuhiro Higuchi. Dirhodium(II)-Catalyzed ortho C-H Amination of N-Alkyldiarylamines. HETEROCYCLES. 2021. 103. 1. 403-403
Kazuhiro Higuchi, Tomomi Kawasaki, Takashi Kouko, Hiroaki Miyazawa, Hideki Hikita, Hiromi Totsuka. Intramolecular Transamidation-Cyclization of N-(α-Oxoacetyl) Diamine: Influence of Solvent, Acidity and Substituents. HETEROCYCLES. 2021. 103. 2. 790-790
Motoki Ito, Yuka Yamabayashi, Mio Oikawa, Emi Kano, Kazuhiro Higuchi, Shigeo Sugiyama. Silica gel-induced aryne generation from o-triazenylarylboronic acids as stable solid precursors. Organic Chemistry Frontiers. 2021. 8. 12. 2963-2969
Kazuhiro Higuchi, Masanori Tayu. The Interrupted Pummerer Reaction: Design of Sulfoxides and Their Utility in Organic Synthesis. HETEROCYCLES. 2021. 102. 5. 783-783

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MISC (1)：

Patents (2)：

ベンジル誘導体の製造方法
Preparation of Intermediates for Novel Antitumor Spiro Compounds, Fredericamycin A and its analogs.

Lectures and oral presentations (9)：

活性チオニウム種やマンニッヒ型反応を用いたインドールアルカロイドの合成研究
(立命館大学総合科学技術研究機構創薬科学研究センター主催創薬基盤化学研究若手セミナー第16回特別講演会 2018)
Sulfonium Species Mediated Coupling Reaction of Phenol Derivatives
(FJS-2016 2016)
Total Synthesis of (-)-Leuconoxine Featuring Mannich-type Intramolecular Cyclization and Chiral Phosphoric Acid-Catalyzed Desymmetrization
(ISHC2015 25th Congress 2015)
イミニウムやチオニウムを用いたインドール骨格を持つ天然物の合成研究
(千葉大学大学院薬学研究院第5回化学系若手研究者講演会 2013)
Active Thionium Species Mediated Functionalization of Indoles
(The 11th International Symposium on Advanced Technology (ISAT-Special) 2012)

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Education (2)：

- 2001 Osaka University
- 1996 Meiji Pharmaceutical University Faculty of Pharmacy Department of Medicinal Chemistry

Professional career (1)：

Work history (7)：

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Committee career (1)：

Association Membership(s) (2)：

THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , 日本薬学会

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