Mandai Hiroki

マンダイヒロキ | Mandai Hiroki

Affiliation and department：
Homepage URL (2)： http://mandai.wpblog.jp/ , http://mandai.wpblog.jp

Research field (2)： Pharmaceuticals - chemistry and drug development , Synthetic organic chemistry

Research keywords (7)：有機化学 , 不斉合成 , 糖鎖合成 , 有機合成化学 , Carbohydrate Chemistry , Asymmetric Synthesis , Synthetic Organic Chemistry

Research theme for competitive and other funds (8)：

2023 - 2027 A Novel Mechanism of Infertility through the Oral-Uterine Interaction Induced by Periodontal Infection and Inflammation
2019 - 2022 不斉求核触媒による高難度分子変換反応の深化と応用
2019 - 2022 超高齢社会での応用を目指す低分子化合物terreinの標的分子の同定・機能解析
2017 - 2019 Development of Enantioselective Acylation Based on Hydrogen-Bonding Strategy
2016 - 2019 Application of anti-inflammatory small molecule compound, terrein and its novel analogue, for the treatment of endodontic or periodontal diseases.

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Papers (60)：

Hidefumi Sako, Kazuhiro Omori, Masaaki Nakayama, Hiroki Mandai, Hidetaka Ideguchi, Saki Yoshimura-Nakagawa, Kyosuke Sakaida, Chiaki Nagata-Kamei, Hiroya Kobayashi, Satoki Ishii, et al. The Fungal Metabolite (+)-Terrein Abrogates Inflammatory Bone Resorption via the Suppression of TNF-α Production in a Ligature-Induced Periodontitis Mouse Model. Journal of Fungi. 2023. 9. 3. 314-314
Koichi Mitsudo, Seiji Suga, Keisuke Shigemori, Taro Shibata, Hiroki Mandai, Eisuke Sato. Electrochemical Cross-Coupling Reactions between Arylboronic Esters and Aryllithiums Using NaBr as a Halogen Mediator. Synthesis. 2023
Kyoko Mandai, Tetsuya Yamamoto, Hiroki Mandai, Aiichiro Nagaki. Rapid gas-liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide. Beilstein Journal of Organic Chemistry. 2022. 18. 660-668
Kyosuke Sakaida, Kazuhiro Omori, Masaaki Nakayama, Hiroki Mandai, Saki Nakagawa, Hidefumi Sako, Chiaki Kamei, Satoshi Yamamoto, Hiroya Kobayashi, Satoki Ishii, et al. The Fungal Metabolite (+)-Terrein Abrogates Ovariectomy-Induced Bone Loss and Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclastogenesis by Suppressing Protein Kinase-C α/βII Phosphorylation. Frontiers in Pharmacology. 2021. 12
Koichi Mitsudo, Yoshiaki Kobashi, Kaito Nakata, Yuji Kurimoto, Eisuke Sato, Hiroki Mandai, Seiji Suga. Cu-Catalyzed Dehydrogenative C-O Cyclization for the Synthesis of Furan-Fused Thienoacenes. Organic Letters. 2021. 23. 11. 4322-4326

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MISC (3)：

Patents (3)：

Lectures and oral presentations (36)：

2nd Asian Network Symposium on Drug Discovery
(Development of Extremely Active Nucleophilic Catalyst for Enantioselective Transformations 2016)
高活性不斉求核触媒を用いたベンゾフラノン類の不斉Steglich転位反応
(第9回有機触媒シンポジウム 2016)
劇的な反応加速効果と高エナンチオ選択性を実現する不斉求核触媒の開発
(分子研研究会「若い世代が創る次世代型分子触媒の開発とその展望」 2016)
高活性な不斉求核触媒を用いたベンゾフラノン類の不斉Steglich転位反応
(第46回複素環化学討論会 2016)
劇的な反応加速効果と高エナンチオ選択性を示す不斉求核触媒の創製
(第32回若手化学者のための化学道場 2016)

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Education (3)：

Professional career (1)：

Work history (4)：

2020/04 - 現在岐阜医療科学大学薬学部薬学科准教授
2019/04 - 2020/03 Gifu University of Medical Science School of Medical Technology lecturer
2008/10 - 2019/03 Assistant Professor,Graduate School of Natural Science and Technology,Okayama University
2006/04 - 2008/09 Researcher,Boston College (Professor Amir H. Hoveyda)

Awards (11)：

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Association Membership(s) (7)：

THE JAPANESE SOCIETY FOR PROCESS CHEMISTRY , 近畿化学協会 , 日本薬学会 , アメリカ化学会 , 有機合成化学協会 , 日本化学会 , American Chemical Society

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