TSUKASA OIKAWA

オイカワツカサ | TSUKASA OIKAWA

Affiliation and department：

Research field (3)： Cell biology , Pathobiochemistry , Medical biochemistry

Research keywords (8)：浸潤 , 破骨細胞 , がん細胞 , 細胞融合 , 細胞極性 , イノシトールリン脂質 , がん , cell biology

Research theme for competitive and other funds (9)：

2022 - 2025 Osteoclast fusion mechanism based on plasma membrane curvature and tension
2020 - 2023 Molecular mechanism of the p53-mediated intra-nuclear dynamics of H3K27me3
2020 - 2022 Regulation of epithelial integrity through the nonequilibrium dynamics of the histone methylation during replication
2018 - 2021 Analysis of the mechanisms by which intra-tumor metabolic microenvironment leads to radioresistance
2016 - 2019 Epigenetic regulation of the epithelial integrity by p53

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Papers (28)：

Tsukasa Oikawa, Junya Hasegawa, Haruka Handa, Naomi Ohnishi, Yasuhito Onodera, Ari Hashimoto, Junko Sasaki, Takehiko Sasaki, Koji Ueda, Hisataka Sabe. p53 secures the normal behavior of H3.1 histone in the nucleus by regulating nuclear phosphatidic acid and EZH2 during the G1/S phase. 2023
Hiroaki Kida, Jing-Jing Jiang, Yuichiro Matsui, Ikuko Takahashi, Rie Hasebe, Daisuke Kawamura, Takeshi Endo, Hiroki Shibayama, Makoto Kondoh, Yasuhiko Nishio, et al. Dupuytren's contracture-associated SNPs increase SFRP4 expression in nonimmune cells including fibroblasts to enhance inflammation development. International immunology. 2023
Mika Watanabe, Hideyuki Kosumi, Shin-Ichi Osada, Shota Takashima, Yunan Wang, Wataru Nishie, Tsukasa Oikawa, Tomonori Hirose, Hiroshi Shimizu, Ken Natsuga. Type XVII collagen interacts with the aPKC-PAR complex and maintains epidermal cell polarity. Experimental dermatology. 2021. 30. 1. 62-67
Shigeru Hashimoto, Shotaro Furukawa, Ari Hashimoto, Akio Tsutaho, Akira Fukao, Yurika Sakamura, Gyanu Parajuli, Yasuhito Onodera, Yutaro Otsuka, Haruka Handa, et al. ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. 2019. 116. 35. 17450-17459
Handa H, Hashimoto A, Hashimoto S, Sugino H, Oikawa T, Sabe H. Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells. Cell communication and signaling : CCS. 2018. 16. 1. 94-94

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MISC (44)：

麓佳月, 高田真吾, 小野寺康仁, 川口喬吾, 畠山鎮次, 佐邊壽孝, 及川司. Macroscopic order formation in myoblast populations driven by intracellular molecular dynamics. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
及川司, 大西なおみ, 小野寺康仁, 橋本あり, 植田幸嗣, 佐邊壽孝. p53 counteracts EZH2 at the nuclear lamina to prevent H3K27 hypermethylation. 日本生化学会大会(Web). 2020. 93rd
橋本あり, 橋本茂, 古川聖太郎, 蔦保暁生, 小野寺康人, 半田悠, 及川司, 水上裕輔, 西川義浩, 児玉裕三, et al. 膵癌ドライバー変異はmRNA翻訳と蛋白質プレニル化を介しARF6が駆動する癌免疫回避を促進する(Pancreatic KRAS/TP53 mutations promote ARF6-based immune evasion via activating mRNA translation and protein prenylation). 日本癌学会総会記事. 2019. 78回. P-3033
及川司, 大西なおみ, 小野寺康仁, 橋本あり, 植田幸嗣, 佐邊壽孝. Requirement for p53 in intra-nuclear dynamics of the K27-trimethylated histone H3 during DNA replication. 日本生化学会大会(Web). 2019. 92nd
橋本あり, 橋本茂, 古川聖太郎, 蔦保暁生, 小野寺康仁, 大塚勇太郎, 半田悠, 及川司, 水上裕輔, 村上正晃, et al. 膵癌ドライバー変異はARF6-AMAP1経路を活性化し悪性度と免疫回避能を促進する(Pancreatic KRAS and TP53 oncogenes cooperatively activate ARF6-AMAP1 pathway to drive malignancy and immune evasion). 日本癌学会総会記事. 2018. 77回. 2219-2219

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Education (2)：

2002 - 2007 The University of Tokyo Graduate School of Pharmaceutical Sciences
1998 - 2002 The University of Tokyo Faculty of Pharmaceutical Sciencees

Professional career (1)：

博士 (薬学) (東京大学)

Work history (4)：

2014/10 - Hokkaido University Assistant Professor
2013/08 - 2014/09 Hokkaido University Graduate School of Medicine Department of Molecular Biology
2009/01 - 2013/07 Keio University School of Medicine
2007/04 - 2008/12 Kobe University Graduate School of Medicine Lipid Biochemistry

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