Art

J-GLOBAL ID：201902273369250764   Reference number：19A2109379

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer

Arf6およびAMAP1は,膵臓癌の浸潤,PD-L1動態および免疫回避を促進するためのKRASおよびTP53変異の主要な標的である【JST・京大機械翻訳】

Author (21)： Hashimoto Shigeru (Department of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Furukawa Shotaro (Department of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Furukawa Shotaro (Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Hashimoto Ari (Department of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Tsutaho Akio (Department of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Tsutaho Akio (Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Fukao Akira (Laboratory of Biochemistry, Graduate School of Pharmaceutical Sciences, Kindai University, 577-8502 Osaka, Japan) ,  Sakamura Yurika (Laboratory of Biochemistry, Graduate School of Pharmaceutical Sciences, Kindai University, 577-8502 Osaka, Japan) ,  Parajuli Gyanu (Laboratory of Immune Regulation, World Premier International Research Center Initiative Immunology Frontier Research Center, Osaka University, 565-0871 Osaka, Japan) ,  Onodera Yasuhito (Department of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Otsuka Yutaro (Department of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Handa Haruka (Department of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Oikawa Tsukasa (Department of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Hata Soichiro (Department of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Nishikawa Yoshihiro (Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 606-8507 Kyoto, Japan) ,  Mizukami Yusuke (Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 078-8510 Asahikawa, Japan) ,  Kodama Yuzo (Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 606-8507 Kyoto, Japan) ,  Murakami Masaaki (Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, 060-0815 Sapporo, Japan) ,  Fujiwara Toshinobu (Laboratory of Biochemistry, Graduate School of Pharmaceutical Sciences, Kindai University, 577-8502 Osaka, Japan) ,  Hirano Satoshi (Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan) ,  Sabe Hisataka (Department of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 116  Issue： 35  Page： 17450-17459  Publication year： 2019 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Although KRAS and TP53 mutatio...

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Thesaurus term： integrin ,  mouse(animal) ,  effector ,  enzyme ,  tumor invasion ,  up-regulation ,  mutation ,  *mRNA
Semi thesaurus term： eIF-4A ,  悪性腫瘍 ,  *ARF6 ,  過剰発現 ,  *TP53 ,  *免疫回避 ,  *AMAP1 , 【Automatic Indexing@JST】

Author keywords (5)： ARF6 ,  mRNA translation ,  pancreatic driver oncogenes ,  PD-L1 ,  mevalonate pathway

JST classification (3)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Biological function  (EB03040U)

Terms in the title (11)： ARF6 ,  AMAP1 ,  膵臓癌 ,  浸潤 ,  PD-L1 ,  免疫回避 ,  促進 ,  KRAS ,  TP53 ,  変異 ,  標的