Rchr

J-GLOBAL ID：200901089154899773 Update date: Apr. 03, 2024

Yoshimoto Takayuki

ヨシモトタカユキ | Yoshimoto Takayuki

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://immunoreg-web-1.jimdosite.com

Research field (7)： Immunology , Functional biochemistry , Tumor biology , Plastic and reconstructive surgery , Nervous system function , Dermatology , Environmental effects of chemicals

Research keywords (13)： IL-6/IL-12ファミリーサイトカイン , IL-27 , IL-23 , IL-35 , Th1/Th2/Th17分化と反応 , 抗腫瘍免疫誘導 , ワクチン , 無針注射器 , 造血幹細胞 , 間葉系幹細胞 , 歯髄幹細胞 , 再生医療 , アレルギー誘発性評価の動物実験代替法

Research theme for competitive and other funds (62)：

2022 - 2025 不死化したヒト脱落乳歯歯髄幹細胞の培養上清による実験的自己免疫性神経炎の治療効果
2022 - 2025 Development of a new treatment method for repairing intestinal epithelial function of inflammatory bowel disease by human pulp MSC-conditioned medium
2022 - 2025 安全性の高い間葉系幹細胞の細胞フリー療法の開発:培養上清の抗腫瘍効果
2022 - 2025 新規無針注入器によるDNA・蛋白質の皮内投与によるワクチン効果と遺伝子治療増強
2021 - 2024 不死化したヒト乳歯歯髄幹細胞の培養上清の基礎的解析と褥瘡マウスモデルの治療効果

2021 - 2024 脳卒中・脊髄損傷の後遺障害のリハビリテーション治療への漢方薬の応用

2021 - 2024 ヒト樹状細胞前駆細胞株とT細胞クローンを用いた新規アレルギー感作性評価法の開発

2019 - 2023 Oncofertility視点に基づく若年癌患者の性腺機能不全の漢方治療法の確立

2019 - 2022 A novel mechanism whereby EBI3, one of IL-27 cytokine subunits, augments target protein expression under inflammatory conditions

2019 - 2022 Development of a novel method to generate human iPS cell-derived dendritic cell progenitors and their effectiveness

2018 - 2021 Comprehensive study on IL-27, one of the IL-12 family cytokines, aiming at its clinical application for cancer immunotherapy

2018 - 2021 Inhibition of pulmonary fibrosis by mesenchymal stem cells through IL-27 and its clinical application

2018 - 2021 Development of a novel alternative to animal testing for the evaluation of respiratory allergic sensitizing potential of chemicals

2017 - 2020 Therapeutic effect of mesenchymal stem cells by anti-inflammatory cytokinesIL-27 and IL-35

2016 - 2020 Elucidation of the mechanism of action of novel antiepileptic drugs using functionalized magnetic nanoparticles and exploration of their neuroprotective effects

2015 - 2019 The effect of traditional medicine on busulfan- and/or irradiation-induced aspermatogenesis

2015 - 2018 A novel role for EBI3, a common subunit of IL-27 and IL-35, as a intracellular molecule in the augmentation of IL-23Ra protein expression

2015 - 2018 Identification and functional analysis of a novel IL-6/IL-12 family cytokine

2015 - 2018 Proliferation and Differentiation of naive helper T cells by Dendritic cells in Human

2015 - 2018 Regulation of the development of psoriasis by ASK1, a stress-responsive MAP kinase

2013 - 2016 Induction of IL-17-producing T cells by VEGF-A as starting molecule: Paradigm shift of psoriasis pathogenesis.

2013 - 2016 The roles and applications of IL-23 and IL-27 in new therapeutic strategies for malignant melanoma and psoriasis

2012 - 2016 Establishment of the differentiation method to spermatogenesis by the xenogeneic transplantation of spermatogonia stem cells and the in vitro culture

2014 - 2015 IL-27により分化誘導したDC前駆細胞を用いた新しい癌DCワクチン療法の開発

2013 - 2015 IL-27による造血幹細胞の運命決定メカニズムの解明

2012 - 2015 Study on the regulation of immune responses by a novel IL-6/IL-12 family cytokine

2012 - 2014 Development of a new cancer immunotherapy with dendritic cells and macrophages by IL-27

2011 - 2013 New mechanism whereby IL-23 regulates immune responses through Notch signalling

2010 - 2012 Basic studies on therapeutic utilities ofIL-27 for malignant melanoma, psoriasis and alopecia areata.

2008 - 2010 Immune regulation by the IL-6/IL-12 family cytokines

2007 - 2008 Analysis of mechanisms of the host defense against parasite infection by new cytokines (IL-27, IL-33)

2007 - 2008 Analysis of antitumor effect by antiangiogenic activity of interleukin-27

2006 - 2008 新しいIL-6/12関連サイトカインIL-27による造血幹細胞の増殖・分化の制御

2005 - 2005 Study of roles of bone microenvironment and immune system in establishment and progression of bone metastasis

2003 - 2004 Therapeutic Strategy for Squamous Cell Carcinoma Resistant to Chemotherapeutic Agents

2002 - 2003 Studies on the signal transduction passways through IL-12 receptor

2002 - 2003 Activation of Caspases via the Mitochondrial Pathway in Hepatocyte Apoptosis -Roles of IAPs and Smac-

2002 - 2003 Basic study for Analysis of Intractable Resistant Tumor Cells and their Overcoming in Cancer Gene Therapy

2001 - 2003 Clinical Application of Tumor-specific Anti-tumor Immunity Induced by Tumor Cells Expressing Fas (CD95) Ligand

2000 - 2000 Th1反応における情報伝達制御機構の解明-IL-12Rを介したIFN-γ産生へのシグナル伝達-

1999 - 2000 Studies on the regulation of IL-12 expression and function and its application to therapy

1999 - 1999 マラリア感染に対する防御免疫機構-赤内型P.berghel強毒株NK65とその弱毒株XATを用いた解析-

1999 - 1999 免疫機能低下の機構解明

1998 - 1999 Elucidation of the mechanism how Vβ T cells aggravate autoimmune diseases and establishment of T cell receptor (TCR)-targeted gene therapies of autoimmune diseases

1997 - 1999 Elucidation of T cell subset Th1 differentiation by IL-12

1998 - 1998 マラリア感染における防御免疫機構の研究-赤内型P.berghei強毒株NK65とその弱毒株XATを用いた検討-

1997 - 1998 Study on the role of IL-12 in protective immunity against infection

1997 - 1998 IL-12の発現調節及び作用機序に関する基礎的研究

1997 - 1997 IL-12遺伝子導入腫瘍を用いた抗腫瘍効果機序の基礎的研究

1996 - 1997 Amelioration of lpr^<cg>-induced autoimmune diseases with Vbeta8.2-specific viral superantigen and its application to gene therapy in mice

1996 - 1996 IL-12遺伝子をもちいた癌免疫療法開発の基礎的研究

1996 - 1996 IL-12による弱毒化マラリア原虫のワクチン効果増強に関する基礎的研究

1996 - 1996 IL-12の発現調節機構に関する基礎的研究

1995 - 1995 T細胞亜集団による免疫制御の分子機構

1995 - 1995 IL-12遺伝子をもちいた癌免疫療法開発の基礎的研究

1995 - 1995 FAS-FASリガンド実験系を用いたアポトーシスによる癌治療の基礎的研究

1995 - 1995 マウスインターロイキン12 (IL-12)の遺伝子構造及びその発現調節機構の解析

1994 - 1994 T細胞亜集団による免疫制御の分子機構

1994 - 1994 レトロウイルス感染による自己免疫疾患誘導の機構解明

1993 - 1993 T細胞亜集団による免疫制御の分子機構

1993 - 1993 先天性アミノ酸尿症の原因としてのヒト塩基性アミノ酸トランスポーターの同定

1992 - 1993 Analysis of cytokine cascade in inflammatory reaction and application for the regulation

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Papers (202)：

Hisashi Nagase, Takuma Kato, Takayuki Yoshimoto. State-of-the-Art Cancer Immunotherapies. International journal of molecular sciences. 2024. 25. 5
Toshihiko Yoneto, Kenichiro Hasumi, Nobukazu Takahashi, Nastuki Seki, Yasutaka Takeda, Takayuki Yoshimoto. Long-lasting complete remission in a patient with systemic metastases of recurrent breast cancer treated with cyclin-dependent kinases 4/6 inhibitors: a case report. Journal of Medical Case Reports. 2023. 17. 1
Jukito Sonoda, Izuru Mizoguchi, Shinya Inoue, Aruma Watanabe, Ami Sekine, Miu Yamagishi, Satomi Miyakawa, Natsuki Yamaguchi, Eri Horio, Yasuhiro Katahira, et al. A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant. International Journal of Molecular Sciences. 2023
Yuma Furusaka, Shinya Inoue, Izuru Mizoguchi, Hideaki Hasegawa, Yasuhiro Katahira, Aruma Watanabe, Eri Sakamoto, Ami Sekine, Satomi Miyakawa, Tomohiro Umezu, et al. Potent antitumor effects of the conditioned medium of bone marrow-derived mesenchymal stem cells via IGFBP -4. Cancer Science. 2023
Yasuhiro Katahira, Fumihiro Murakami, Shinya Inoue, Satomi Miyakawa, Eri Sakamoto, Yuma Furusaka, Aruma Watanabe, Ami Sekine, Masahiko Kuroda, Hideaki Hasegawa, et al. Protective effects of conditioned media of immortalized stem cells from human exfoliated deciduous teeth on pressure ulcer formation. Frontiers in Immunology. 2023. 13

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MISC (159)：

片平泰弘, 樋口廣士, 山本雄一郎, 安藤潔, 幸谷愛, 松下弘道, 八幡崇, 小池亮, 佐藤克明, 今留謙一, et al. Increased Granulopoiesis in the Bone Marrow following Epstein-Barr Virus Infection(和訳中). 東京医科大学雑誌. 2020. 78. 3. 290-291
高松朋子, 山中岳, 春日晃子, 竹下美佳, 森地振一郎, 石田悠, 小穴信吾, 柏木保代, 河島尚志, 溝口出, et al. Expression of intracellular cytokines in twins with intractable epilepsy associated with lissencephaly. 東京医科大学雑誌. 2020. 78. 3
山中岳, 溝口出, 山崎崇志, 高松朋子, 小穴信吾, 森地振一郎, 石田悠, 柏木保代, 善本隆之, 河島尚志. 急性脳炎・脳炎滑脳症に伴うてんかん性脳症双胎例に対するフローサイトメトリーを用いた免疫学的アプローチ. 神経免疫学. 2019. 24. 1. 110-110
大脇敏之, 大脇敏之, 菅原京加, 落合央, 落合央, 溝口出, 千葉佑規乃, 長谷川英哲, 折井直子, 宮本泰則, et al. ヒト間葉系幹細胞による免疫調節とIL-27の関係性. 日本再生医療学会総会(Web). 2018. 17th
森朋子, 山中岳, 溝口出, 小穴信吾, 石田悠, 竹下美佳, 森下那月美, 森地振一郎, 浦辺智美, 呉宋憲, et al. フローサイトメトリーによる複雑型熱性けいれんの免疫学的検討. てんかん研究. 2017. 35. 2. 482-482

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Patents (10)：

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Books (3)：

Modification of tumor cells with Fas(CD95)antigen gene and Fas ligand(CD95L)gene transfection by electroporation for immunotherapy of cancer.
Cancer Immunotherapy Protocols. Humana Press, Belgium, in press. 1999
MTV-Encoded Superantigen Expression in B Lymphoma Cells in SJL Mice as A Stimulus for "Reversed Immunological Surveillance"
Superantigens : A Pathogen's View of the Immune System 1993
Synthetic Polymer-Protein Hybrids : Modification of L-Asparaginase with Polyethylene Glycol
Multiphase Biomedical Materials (VNU Science Press) 1989

Education (3)：

1986 - 1989 Tokyo Institute of Technology Graduate School, Division of Natural Science
1984 - 1986 Tokyo Institute of Technology
1980 - 1984 Tokyo Institute of Technology Faculty of Science

Professional career (2)：

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Work history (6)：

2010/12 - 現在 Tokyo Medical University
2008/06 - 2010/11 Tokyo Medical University
2000/01 - 2008/05 Tokyo Medical University
1992/04 - 1999/12 The University of Tokyo
1989/04 - 1992/03 New ork University Medical Center Department of Pathology (Prof. Daniel Meruelo) ポスドク

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Committee career (3)：

2014/06 - 現在日本インターフェロン・サイトカイン学会幹事
2013/10 - 現在日本癌学会評議員
2005/01 - 現在日本免疫学会評議員

Association Membership(s) (5)：

日本免疫学会 , 日本インターフェロン・サイトカイン学会 , 日本再生医療学会 , 日本動物実験代替法学会 , 日本癌学会

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