Mandai Kenji

マンダイケンジ | Mandai Kenji

Affiliation and department：
Job title： Associate Professor

Research field (4)： Neuroscience - general , Medical biochemistry , Cell biology , Molecular biology

Research keywords (4)： Neurobiology , Cell biology , Molecular biology , Biochemistry

Research theme for competitive and other funds (13)：

2021 - 2024 Functions and mechanisms of action of cell adhesion-related molecules in the formation of the cerebral cortex and synapses
2018 - 2021 Role of linx in axon guidance and its mechanism of action
2016 - 2021 Scrap& build of synapse towards understanding neuropsychiatric disorders
2013 - 2015 大脳新皮質の神経投射を制御する分子機構の解明
2012 - 2015 Roles of afadin and nectins in synapse formation

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Papers (57)：

Tomohiko Maruo, Kiyohito Mizutani, Muneaki Miyata, Toshihiko Kuriu, Shotaro Sakakibara, Hatena Takahashi, Daichi Kida, Kouki Maesaka, Tsukiko Sugaya, Ayuko Sakane, et al. s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons. The Journal of biological chemistry. 2023. 299. 4. 103040-103040
Hajime Shiotani, Muneaki Miyata, Takeshi Kameyama, Kenji Mandai, Miwako Yamasaki, Masahiko Watanabe, Kiyohito Mizutani, Yoshimi Takai. Nectin-2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula. Journal of Comparative Neurology. 2021. 529. 2. 450-477
Lin Luo, Mateusz C Ambrozkiewicz, Fritz Benseler, Cui Chen, Emilie Dumontier, Susanne Falkner, Elisabetta Furlanis, Andrea M Gomez, Naosuke Hoshina, Wei-Hsiang Huang, et al. Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. Neuron. 2020. 106. 1. 37-65
山森早織, 安田修一, 渡辺滋, 宮岡等, 萬代研二. ストレス刺激による脳内SNAP-25のリン酸化とモノアミン放出の変化. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [3P-313]
Hajime Shiotani, Muneaki Miyata, Kiyohito Mizutani, Shujie Wang, Akira Mizoguchi, Hideki Mochizuki, Kenji Mandai, Yoshimi Takai. Interaction of nectin-2α with the auxiliary protein of the voltage-gated A-type K+ channel Kv4.2 dipeptidyl aminopeptidase-like protein at the boundary between the adjacent somata of clustered cholinergic neurons in the medial habenula. Molecular and cellular neurosciences. 2019. 94. 32-40

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MISC (51)：

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Patents (3)：

Actin filament-binding protein “l-Afadin
蛋白質ポンシン
アクチン結合蛋白質l-アファディン

Books (2)：

脳内環境辞典 / アファディン
メディカルドゥ社 2017
血小板生物学 / 低分子量G蛋白質
メディカルレビュー社 2004

Lectures and oral presentations (27)：

ストレス刺激による脳内SNAP-25のリン酸化とモノアミン放出の変化
(第92回日本生化学会大会 2019)
Localization of Stress-induced Phosphorylated Proteins in the Mouse Brain
(2018)
Afadin plays multiple roles in the structural and functional differentiations of hippocampal giant mossy fiber synapses
(Cold Spring Harbor Asia Meeting-Latest advances in development & function of neural circuits 2018)
Analysis of a novel cell adhesion mechanism, the nectin-1-mediated Self-to-Self adhesion, in the mouse retina
(2017)
Localization and functions of nectin-2 in the brain
(2017)

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Education (1)：

- 1990 Osaka University Faculty of Medicine Medical School

Professional career (1)：

M.D. (Osaka University)

Work history (11)：

2018 - 現在北里大学大学院医療系研究科分子細胞神経生物学主任教授
2018 - 現在北里大学医学部生化学主任教授
2013 - 国立大学法人神戸大学大学院医学研究科生化学・分子生物学講座病態シグナル学特命准教授
2011 - 国立大学法人神戸大学大学院医学研究科生化学・分子生物学講座分子細胞生物学特命講師
2002 - ジョンズホプキンス大学医学部ハワード・ヒューズ医学研究所神経科学研究員

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Awards (1)：

2000 - 公益財団法人井上科学振興財団井上研究奨励賞(Inoue Research Award for Young Scientists) 細胞-細胞間接着結合に存在するPDZドメインを持つ新規アクチン結合蛋白質:アファディン

Association Membership(s) (3)：

The Japan Neuroscience Society , 日本内科学会 , 日本生化学会

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