Art

J-GLOBAL ID：202002234010751136   Reference number：20A0883083

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

Creドライバー系統による神経系特異的遺伝子ターゲッティングの最適化:生殖系列組換えの有病率と影響因子【JST・京大機械翻訳】

Author (74)： Luo Lin (Djavad Mowafaghian Centre for Brain Health and Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada) ,  Ambrozkiewicz Mateusz C. (Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Ambrozkiewicz Mateusz C. (Institute of Cell Biology and Neurobiology, Charite-Universitaetsmedizin Berlin, corporate member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, and Berlin Institute of Health, Chariteplatz 1, 10117 Berlin, Germany) ,  Benseler Fritz (Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Chen Cui (State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China) ,  Dumontier Emilie (Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada) ,  Falkner Susanne (Biozentrum of the University of Basel, Basel, Switzerland) ,  Furlanis Elisabetta (Biozentrum of the University of Basel, Basel, Switzerland) ,  Gomez Andrea M. (Biozentrum of the University of Basel, Basel, Switzerland) ,  Hoshina Naosuke (F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA) ,  Huang Wei-Hsiang (Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA) ,  Huang Wei-Hsiang (Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada) ,  Hutchison Mary Anne (Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA) ,  Itoh-Maruoka Yu (Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Lavery Laura A. (Department of Molecular and Human Genetics, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, TX 77003, USA) ,  Lavery Laura A. (Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA) ,  Li Wei (State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China) ,  Maruo Tomohiko (Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Maruo Tomohiko (Department of Biochemistry, Tokushima University Graduate School of Medical Sciences, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan) ,  Maruo Tomohiko (Department of Biochemistry, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan) ,  Motohashi Junko (Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Pai Emily Ling-Lin (Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA) ,  Pai Emily Ling-Lin (Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA) ,  Pelkey Kenneth A. (Section on Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA) ,  Pereira Ariane (Department of Neurobiology and Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA) ,  Philips Thomas (Department of Neurology and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Sinclair Jennifer L. (Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA) ,  Stogsdill Jeff A. (Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA) ,  Stogsdill Jeff A. (Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02139, USA) ,  Traunmueller Lisa (Biozentrum of the University of Basel, Basel, Switzerland) ,  Wang Jiexin (Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA) ,  Wortel Joke (Department of Functional Genomics and Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam and University Medical Center Amsterdam, de Boelelaan 1085, 1081 HV Amsterdam, the Netherlands) ,  You Wenjia (Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA) ,  You Wenjia (Departments of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  You Wenjia (Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA) ,  Abumaria Nashat (State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China) ,  Abumaria Nashat (Department of Laboratory Animal Science, Shanghai Medical College, Fudan University, Shanghai 200032, China) ,  Beier Kevin T. (Department of Physiology and Biophysics, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA) ,  Brose Nils (Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Burgess Harold A. (Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA) ,  Cepko Constance L. (Departments of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Cepko Constance L. (Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA) ,  Cloutier Jean-Francois (Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada) ,  Eroglu Cagla (Department of Cell Biology, Department of Neurobiology, and Duke Institute for Brain Sciences, Regeneration Next Initiative, Duke University Medical Center, Durham, NC 27710, USA) ,  Goebbels Sandra (Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Kaeser Pascal S. (Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA) ,  Kay Jeremy N. (Department of Neurobiology and Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA) ,  Lu Wei (Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA) ,  Luo Liqun (Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA) ,  Mandai Kenji (Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Mandai Kenji (Department of Biochemistry, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan) ,  McBain Chris J. (Section on Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA) ,  Nave Klaus-Armin (Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Prado Marco A.M. (Robarts Research Institute, Department of Anatomy and Cell Biology, and Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5B7, Canada) ,  Prado Marco A.M. (Brain and Mind Institute, The University of Western Ontario, London, ON N6A 5B7, Canada) ,  Prado Vania F. (Robarts Research Institute, Department of Anatomy and Cell Biology, and Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5B7, Canada) ,  Prado Vania F. (Brain and Mind Institute, The University of Western Ontario, London, ON N6A 5B7, Canada) ,  Rothstein Jeffrey (Department of Neurology and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Rubenstein John L.R. (Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA) ,  Rubenstein John L.R. (Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA) ,  Saher Gesine (Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Sakimura Kenji (Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan) ,  Sanes Joshua R. (Center for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA) ,  Scheiffele Peter (Biozentrum of the University of Basel, Basel, Switzerland) ,  Takai Yoshimi (Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Umemori Hisashi (F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA) ,  Verhage Matthijs (Department of Functional Genomics and Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam and University Medical Center Amsterdam, de Boelelaan 1085, 1081 HV Amsterdam, the Netherlands) ,  Yuzaki Michisuke (Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Zoghbi Huda Yahya (Department of Molecular and Human Genetics, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, TX 77003, USA) ,  Zoghbi Huda Yahya (Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA) ,  Kawabe Hiroshi (Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Kawabe Hiroshi (Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Kawabe Hiroshi (Department of Gerontology, Laboratory of Molecular Life Science, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, 2-2 Minatojima-minamimachi Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Craig Ann Marie (Djavad Mowafaghian Centre for Brain Health and Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada)
Material： Neuron
Volume： 106  Issue： 1  Page： 37-65.e5  Publication year： 2020 
JST Material Number： T0649A  ISSN： 0896-6273  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The Cre-loxP system is invalua...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A0883083&from=J-GLOBAL&jstjournalNo=T0649A") }}

Thesaurus term： recombination (connection) ,  mosaic ,  *Nervous System ,  spermatozoon ,  targeting ,  recombinase ,  community (group) ,  Oocytes ,  knocking ,  neuroscience ,  *optimization ,  bias ,  *Heredity ,  *gene targetting ,  transcription control ,  *modification

Author keywords (10)： site-specific recombinase ,  Cre-lox ,  germline recombination ,  mosaic recombination ,  conditional gene targeting ,  conditional knockout ,  conditional knockin ,  conditional reporter ,  molecular genetics ,  parental sex bias

JST classification (1)： Gene manipulation  (EC02050B)

Terms in the title (10)： Cre ,  ドライバー ,  系統 ,  神経系 ,  遺伝子ターゲッティング ,  最適化 ,  生殖系列 ,  組換え ,  有病率 ,  影響因子