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J-GLOBAL ID：201702236754724576   Reference number：17A0271802

炎症性疾患に対するIL-6阻害療法:現状と今後の展開

Author (1)： TANAKA TOSHIO (大阪大学大学院医学系研究科抗体医薬臨床応用学講座)
Material： 日本臨床免疫学会会誌  (Japanese Journal of Clinical Immunology)
Volume： 38  Issue： 6  Page： 433-442(J-STAGE)  Publication year： 2015 
JST Material Number： X0337A  ISSN： 0911-4300  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： interleukin 6 ,...
Semi thesaurus term： *interleukin-6 inhibitor ,...

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Author keywords (3)： IL-6 ,  chronic immune-mediated diseases ,  cytokine storm

JST classification (4)： Drug therapy(=pharmacotherapy)for musculoskeletal diseases  (GG05020D) ,  Clinical application of anti-inflammatory drugs  (GW15020E) ,  Clinical application of immunotherapeutic agents and blood preparations  (GW22020O) ,  Drug therapy(=pharmacotherapy)for hematologic diseases in general  (GK05020P)

Reference (64)：

• 1) Tanaka, T., et al.: Therapeutic targeting of the interleukin-6 receptor. Annu Rev Pharmacol Toxicol. 52: 199-219, 2012.
• 2) Yokota, S., et al.: Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis. Ther Adv Musculo Dis. 4: 387-397, 2012.
• 3) Kang, S., et al.: Therapeutic uses of anti-interleukin-6 receptor antibody. Int Immunol. 27: 21-29, 2015.
• 4) Kishimoto, T., Ishizaka, K.: Regulation of antibody response in vitro. VII. Enhancing soluble factors for IgG and IgE antibody response. J Immunol. 111: 1194-1205, 1973.
• 5) Hirano, T., et al.: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature. 324: 73-76, 1986.

Terms in the title (5)： 炎症性疾患 ,  阻害 ,  療法 ,  現状 ,  展開