tomiyama takami | Researcher Information

2009 - 2009 Physiological function of Aβ in regulation of brain cholesterol
2008 - 2009 Aβオリゴマー仮説を検証する新しいアルツハイマー病モデルマウスの作製
2005 - 2007 Molecular imaging ofAlzheimer amyloid
2004 - 2005 Alternated splicing of tau in development and neurodegenerating disorders with dementia.
2001 - 2004 Fundamental study on the molecular mechanism for neuropathological changes of dementia

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Tomohiro Umeda, Hiroshi Mori, Hui Zheng, Takami Tomiyama. Regulation of cholesterol efflux by amyloid β secretion. Journal of Neuroscience Research. 2010. 88. 9. 1985-1994
Takami Tomiyama, Shogo Matsuyama, Hiroyuki Iso, Tomohiro Umeda, Hiroshi Takuma, Kiyouhisa Ohnishi, Kenichi Ishibashi, Rie Teraoka, Naomi Sakama, Takenari Yamashita, et al. A Mouse Model of Amyloid beta Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo. JOURNAL OF NEUROSCIENCE. 2010. 30. 14. 4845-4856
Kei Suga, Ayako Saito, Takami Tomiyama, Hiroshi Mori, Kimio Akagawa. The Syntaxin 5 Isoforms Syx5 and Syx5L have Distinct Effects on the Processing of beta-amyloid Precursor Protein. JOURNAL OF BIOCHEMISTRY. 2009. 146. 6. 905-915
Kazuhiro Ito, Ken-Ichi Ishibashi, Takami Tomiyama, Tomohiro Umeda, Kei-Ichi Yamamoto, Erika Kitajima, Toshiki Idomoto, Toshie Nagatomo, Hiroshi Mori. Oligomeric Amyloid beta-Protein as a Therapeutic Target in Alzheimer's Disease: Its Significance Based on its Distinct Localization and the Occurrence of a Familial Variant Form. CURRENT ALZHEIMER RESEARCH. 2009. 6. 2. 132-136
Kazuchika Nishitsuji, Takami Tomiyama, Kenichi Ishibashi, Kazuhiro Ito, Rie Teraoka, Mary P. Lambert, William L. Klein, Hiroshi Mori. The E693 Delta Mutation in Amyloid Precursor Protein Increases Intracellular Accumulation of Amyloid beta Oligomers and Causes Endoplasmic Reticulum Stress-Induced Apoptosis in Cultured Cells. AMERICAN JOURNAL OF PATHOLOGY. 2009. 174. 3. 957-969

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Animal models of Alzheimer's disease. Japanese journal of clinical medicine. 2008. 66. 127-133
富山貴美, 森啓. Alzheimer病における神経細胞死機構 (第1土曜特集 Alzheimer病--基礎・臨床研究の最新動向) -- (基礎研究). 医学のあゆみ. 2007. 220. 5. 379-384
富山貴美, 森啓. 細胞外・細胞内Aβオリゴマーによるシナプス機能障害と神経細胞死 (第1土曜特集神経保護・再生医療研究の最前線) -- (神経保護). 医学のあゆみ. 2005. 215. 10. 799-803
Kosaka Satoru, Takuma Hiroshi, Tomiyama Tamaki. The Distributions of Tau Short and Long Isoforms Fused with EGFP in Cultured Cells. Osaka City Medical journal. 2004. 50. 1. 19-27
K Ishii, C Lippa, T Tomiyama, F Miyatake, K Ozawa, A Tamaoka, T Hasegawa, PE Fraser, S Shoji, LE Nee, et al. Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition. NEUROBIOLOGY OF AGING. 2001. 22. 3. 367-376

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Rearrangement of microtubule networks by tau bearing missense mutations
Neuroscientific Basis of Dementia 2001
Development of a human monoclonal antibody against cytomegalovirus with the aim of a passive immunotherapy
Stockton Press 1990

- 1986 Tokyo Institute of Technology Interdisciplinary Science and Engineering
- 1986 Tokyo Institute of Technology Graduate School, Division of Integrated Science and Engineering
- 1984 Tokyo Institute of Technology School of Science
- 1984 Tokyo Institute of Technology Faculty of Science

理学博士

2008 - 2009 大阪市立大学医学(系)研究科(研究院) 准教授
2007 - 大阪市立大学医学研究科・大学院准教授
2006 - Osaka City University Graduate School of Medicine
2001 - 2005 大阪市立大学医学研究科・大学院講師
2004 - Osaka City University Graduate School of Medicine

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2008 - 日本認知症学会評議員

2008 - 日本認知症学会奨励賞

米国神経科学会 , 日本認知症学会