Okubo Naoto

オオクボナオト | Okubo Naoto

Affiliation and department：
Job title： Lecturer
Homepage URL (1)： https://www.pharm.hokudai.ac.jp/byoutai/index.html

Research field (2)： Regenerative dentistry and dental engineering , Oral medicine

Research keywords (5)： Periodontal ligament stem cells , Demineralized Dentin Matrix , Scaffolds for stem cells , 再生医療 , 間葉系幹細胞

Research theme for competitive and other funds (18)：

2023 - 2027 高性能スキャホールドを活用した軟組織マネージメントを加味した顎骨再生療法の開発
2021 - 2024 動物の歯を利用した脱灰象牙質由来コラーゲン顆粒骨再生材料の研究開発
2022 - 2023 健康長寿社会実現のための疾患罹患リスク予知関連「新規指標」の探索
2018 - 2022 The establishment of novel bone regenerative therapies utilizing the Periodontal ligament stem cells / demineralized Dentin matrix hybrid grafting materials
2021 - 2022 疾患罹患リスクの予知につながる非侵襲性光感受型医療用デバイスの開発

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Papers (33)：

Masaru Murata, Takashi Nezu, Hiroaki Takebe, Yukito Hirose, Naoto Okubo, Takashi Saito, Toshiyuki Akazawa. Human dentin materials for minimally invasive bone regeneration: Animal studies and clinical cases. Journal of Oral Biosciences. 2022
Yusuke Matsuzawa, Naoto Okubo, Soichi Tanaka, Haruhiko Kashiwazaki, Yoshimasa Kitagawa, Yoichi Ohiro, Tadashi Mikoya, Toshiyuki Akazawa, Masaru Murata. Primary Teeth-Derived Demineralized Dentin Matrix Autograft for Unilateral Maxillary Alveolar Cleft during Mixed Dentition. J. Funct. Biomater. 2022. 13. 3. 153-153
Naoto Okubo, Masahiro Ishikawa, Mamata Shakya, Hidetaka Hosono, Osamu Maehara, Tatsuya Ohkawara, Shunsuke Ohnishi, Toshiyuki Akazawa, Masaru Murata. Autograft of Demineralized Dentin Matrix Prepared Immediately after Extraction for Horizontal Bone Augmentation of the Anterior Atrophic Maxilla: A First Case of Non-Vital Tooth-Derived Dentin. Journal of Hard Tissue Biology. 2022. 31. 1. 47-54
Osamu Maehara, Goki Suda, Mitsuteru Natsuizaka, Taku Shigesawa, Gouki Kanbe, Megumi Kimura, Masaya Sugiyama, Masashi Mizokami, Masato Nakai, Takuya Sho, et al. FGFR2 maintains cancer cell differentiation via AKT signaling in esophageal squamous cell carcinoma. Cancer biology & therapy. 2021. 22. 5-6. 372-380
Tatsuya Ohkawara, Naoto Okubo, Osamu Maehara, Jun Nishihira, Hiroshi Takeda. Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice. Toxicology letters. 2021. 339. 51-59

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MISC (42)：

客本斉子, 滝沢尚希, 大久保直登, 加茂政晴, 帖佐直幸, 横田聖司, 大塚正人, 衣斐美歩, 石崎明. 低酸素培養下においてマウス骨髄由来間葉系幹細胞は細胞間接着依存的ならびに非依存的に免疫抑制(抗炎症)性マクロファージ(M2-Mφ)を誘導する. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.2LBA-091 (WEB ONLY)-091]
客本斉子, 滝沢尚希, 大久保直登, 加茂政晴, 帖佐直幸, 横田聖司, 大塚正人, 衣斐美歩, 石崎明. 低酸素培養下においてマウス骨髄由来間葉系幹細胞は細胞間接着依存的ならびに非依存的に免疫抑制(抗炎症)性マクロファージ(M2-Mφ)を誘導する. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.2LBA-091 (WEB ONLY)-091]
大久保直登, 村田勝, 赤澤敏之, 中川宏治, 帖佐直幸, 武田宏司, 石崎明. ラット歯根膜幹細胞由来筋線維芽細胞の収縮作用による歯周免疫機構への物理的関与. 硬組織再生生物学会学術大会・総会プログラム・抄録集. 2017. 26th. 34
Hiroshi Takeda, Chihiro Yamada, Yayoi Saegusa, Koji Nakagawa, Naoto Okubo, Miwa Nahata, Tomohisa Hattori. Gender Difference in Ghrelin Dynamics and Responsiveness During Psychological Stress in Mice Model. GASTROENTEROLOGY. 2016. 150. 4. S427-S427
Hiroshi Takeda, Chihiro Yamada, Yayoi Saegusa, Koji Nakagawa, Naoto Okubo, Miwa Nahata, Tomohisa Hattori. Rikkunshito Improves Stress-Induced Anorexia in Aged Female Mice via Stimulation of Ghrelin Secretion. GASTROENTEROLOGY. 2016. 150. 4. S427-S428

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Education (1)：

2005 - 2009 国立大学法人北海道大学大学院歯学研究科博士課程口腔医学専攻

Professional career (1)：

歯学博士 (北海道大学)

Work history (5)：

2022/04 - 現在 Faculty of Parmaceutical sciences, Hokkaido University Laboratory of Molecular and Cellular Medicine Lecturer
2021/04 - 2022/03 Faculty of Parmaceutical sciences, Hokkaido University Laboratory of Molecular and Cellular Medicine Assistant Professor
2019/04 - 2021/03 Faculty of Parmaceutical sciences, Hokkaido University Laboratory of Pathophysiology and Therapeutics Assistant Professor
2012/12 - 2019/03 Faculty of Parmaceutical sciences, Hokkaido University Laboratory of Pathophysiology and Therapeutics Postdoctoral Fellow
2010 - 2012 Iwate Medical University School of Dentistry Postdoctoral Fellow

Awards (4)：

2021/02 - 北海道経済部産業振興局令和2年度北海道科学技術奨励賞
2011/05 - 平成23年度北海道歯学会: 北海道歯学会賞
2010/07 - 第70回岩手科大学歯学会: 岩手歯学会賞
2009/09 - 第18回硬組織再生生物学会最優秀ポスター賞

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