Rchr
J-GLOBAL ID：201401034651071623   Update date: Apr. 18, 2024

Makiyama Takeru

Makiyama Takeru
Research field  (1)： Cardiology
Research theme for competitive and other funds  (15)：
  • 2021 - 2026 臨床予後予測に向けたiPS細胞由来心筋症モデルによる特発性拡張型心筋症の病態解明
  • 2022 - 2025 バイオインフォマティクスを用いた非コードDNA解析による若年突然死の発症機序解明
  • 2021 - 2024 The elucidation of complicated genetic backgrounds and pathogenicity in patients with inherited primary arrhythmia syndromes caused by unknown etiology
  • 2020 - 2023 Elucidation of molecular pathogenesis for inherited lethal arrhythmia associated with transporter abnormalities
  • 2019 - 2022 Elucidation of the pathogenesis of lethal inherited arrhythmias using iPS cells and development of therapeutic approaches
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Papers (252)：
  • Megumi Fukuyama, Minoru Horie, Koichi Kato, Hisaaki Aoki, Shuhei Fujita, Yoko Yoshida, Hisanori Sakazaki, Takako Toda, Michihiko Ueno, Gaku Izumi, et al. Calmodulinopathy in Japanese Children - Their Cardiac Phenotypes Are Severe and Show Early Onset in Fetal Life and Infancy. Circulation journal : official journal of the Japanese Circulation Society. 2023
  • Jingshan Gao, Takeru Makiyama, Yuta Yamamoto, Takuya Kobayashi, Hisaaki Aoki, Thomas L Maurissen, Yimin Wuriyanghai, Asami Kashiwa, Tomohiko Imamura, Takanori Aizawa, et al. Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation. Arrhythmia and electrophysiology. 2023. 16. 3. e011387
  • Takanori Aizawa, Yuko Wada, Kanae Hasegawa, Hai Huang, Tomohiko Imamura, Jingshan Gao, Asami Kashiwa, Hirohiko Kohjitani, Megumi Fukuyama, Koichi Kato, et al. Non-missense variants of KCNH2 show better outcomes in type 2 long QT syndrome. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2023. 25. 4. 1491-1499
  • Yuki Nagata, Ryo Watanabe, Christian Eichhorn, Seiko Ohno, Takeshi Aiba, Taisuke Ishikawa, Yukiko Nakano, Yoshiyasu Aizawa, Kenshi Hayashi, Nobuyuki Murakoshi, et al. Targeted deep sequencing analyses of long QT syndrome in a Japanese population. PloS one. 2022. 17. 12. e0277242
  • Hirohiko Kohjitani, Shigeya Koda, Yukiko Himeno, Takeru Makiyama, Yuta Yamamoto, Daisuke Yoshinaga, Yimin Wuriyanghai, Asami Kashiwa, Futoshi Toyoda, Yixin Zhang, et al. Gradient-based parameter optimization method to determine membrane ionic current composition in human induced pluripotent stem cell-derived cardiomyocytes. Scientific reports. 2022. 12. 1. 19110-19110
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MISC (460)：
  • 井上智之, 喜多村恭平, 羽賀博典, 森永晃史, 米田史哉, 西脇修司, 田中宗和, 糀谷泰彦, 牧山武, 尾野亘, et al. 持続性心房細動に対するアブレーション中に大量の右左シャントによる低酸素血症で救命困難となった不整脈原性右室心筋症の1例. 日本心臓病学会学術集会(Web). 2023. 71st
  • KOHJITANI Hirohiko, KOHJITANI Hirohiko, MITANI Takeshi, OKAMOTO Yuji, AIZAWA Takanori, MAKIYAMA Takeru, MAKIYAMA Takeru, KASHIWA Asami, IMAMURA Tomohiko, OHNO Seiko, et al. Development of Precise Genetic Prognostic Model for Hereditary Arrhythmia Disease Using Machine Learning. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2022. 68th
  • KASHIWA Asami, MAKIYAMA Takeru, WADA Yuko, OZAWA Junichi, AIZAWA Takanori, IMAMURA Tomohiko, HUANG Hai, GAO Jingshan, KOHJITANI Hirohiko, OHNO Seiko, et al. Arrhythmic Risk is NOT Homogeneous in C-Terminal KCNQ1 Variants of Long QT Syndrome. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2022. 68th
  • GAO Jingshan, MAKIYAMA Takeru, YAMAMOTO Yuta, KOBAYASHI Takuya, AOKI Hisaaki, MAURISSEN L Thomas, KASHIWA Asami, IMAMURA Tomohiko, AIZAWA Takanori, HUANG Hai, et al. Novel CPVT-Associated Calmodulin Mutation Activating RyR2 Channels Causes Robust Arrhythmogenicity in iPS Cell Model. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2022. 68th
  • IMAMURA Tomohiko, MAKIYAMA Takeru, OZAWA Junichi, HUANG Hai, AIZAWA Takanori, GAO Jingshan, KASHIWA Asami, KOHJITANI Hirohiko, KATO Koichi, AOKI Hisaaki, et al. Clinical Characteristics and Risk Stratification in Pediatric Brugada Syndrome. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2022. 68th
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Patents (3)：
Books (3)：
  • 変化と環境 : テクノロジーは何を変えるのか
    産業能率短期大学出版部 1970
  • 技術と変化 : テクノロジーの波及効果
    産業能率短期大学出版部 1970
  • 研究開発プロジェクト : その評価と管理
    日本能率協会 1969
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