文献

J-GLOBAL ID：201602283126639503   整理番号：16A1006987

急性冠症候群の日本人患者における血小板凝集の阻害および主要な有害心血管イベントに与えるCYP2C19の影響:PRASFIT-ACS試験

Effects of CYP2C19 allelic variants on inhibition of platelet aggregation and major adverse cardiovascular events in Japanese patients with acute coronary syndrome: The PRASFIT-ACS study

著者 (15件)： Ogawa Hisao (Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Ogawa Hisao (National Cerebral and Cardiovascular Center, Osaka, Japan) ,  Isshiki Takaaki (Division of Cardiology, Ageo Central General Hospital, Saitama, Japan) ,  Kimura Takeshi (Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Yokoi Hiroyoshi (Cardiovascular Medicine Center, Fukuoka Sanno Hospital, Fukuoka, Japan) ,  Yokoi Hiroyoshi (International University of Health and Welfare, Tochigi, Japan) ,  Nanto Shinsuke (Nishinomiya Hospital Affairs, Nishinomiya Municipal Central Hospital, Hyogo, Japan) ,  Takayama Morimasa (Sakakibara Heart Institute, Tokyo, Japan) ,  Kitagawa Kazuo (Department of Neurology, Graduate School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan) ,  Nishikawa Masakatsu (Clinical Research Support Center, Mie University Hospital, Mie, Japan) ,  Miyazaki Shunichi (Division of Cardiology, Department of Medicine, Faculty of Medicine, Kinki University, Osaka, Japan) ,  Ikeda Yasuo (Life Science & Medical Bioscience, Faculty of Science and Engineering, Waseda University, Tokyo, Japan) ,  Nakamura Masato (Division of Cardiovascular Medicine, Ohashi Medical Center, Toho University, Tokyo, Japan) ,  Tanaka Yuko (Clinical Data & Biostatistics Department, R&D Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan) ,  Saito Shigeru (Division of Cardiology, Shonan Kamakura General Hospital, Kamakura, Japan)
資料名： Journal of Cardiology  (Journal of Cardiology)
巻： 68  号： 1  ページ： 29-36  発行年： 2016年07月 
JST資料番号： W2218A  ISSN： 0914-5087  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 背景:経皮的冠動脈インターベンション(PCI)を行った急性冠...

シソーラス用語： *冠動脈疾患 ,...
準シソーラス用語： *急性冠症候群 ,...

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著者キーワード (5件)： Prasugrel ,  Clopidogrel ,  CYP2C19 ,  Major adverse cardiovascular events ,  Platelet aggregation

分類 (4件)： 循環系の診断  (GJ02000V) ,  酵素一般  (EB09010D) ,  術後処置・予後  (GC07050M) ,  血液・体液作用薬の臨床への応用  (GW14020X)

物質索引 (3件)： クロピドグレル ,  プラスグレル ,  アスピリン

引用文献 (32件)：

• Murasaki K. Guidelines for management of anticoagulant and antiplatelet therapy in cardiovascular disease (JCS 2009). Nihon Rinsho 2011;69(Suppl.9):567-71 [in Japanese].
• Cuisset T, Loosveld M, Morange PE, Quilici J, Moro PJ, Saut N, Gaborit B, Castelli C, Beguin S, Grosdidier C, Fourcade L, Bonnet JL, Alessi MC. CYP2C19^*2 and ^*17 alleles have a significant impact on platelet response and bleeding risk in patients treated with prasugrel after acute coronary syndrome. JACC Cardiovasc Interv 2012;5:1280-7.
• Frere C, Cuisset T, Morange PE, Quilici J, Camoin-Jau L, Saut N, Faille D, Lambert M, Juhan-Vague I, Bonnet JL, Alessi MC. Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome. Am J Cardiol 2008;101:1088-93.
• Hulot JS, Bura A, Villard E, Azizi M, Remones V, Goyenvalle C, Aiach M, Lechat P, Gaussem P. Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood 2006;108:2244-7.
• Mega JL, Close SL, Wiviott SD, Shen L, Hockett RD, Brandt JT, Walker JR, Antman EM, Macias W, Braunwald E, Sabatine MS. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med 2009;360:354-62.

タイトルに関連する用語 (9件)： 急性冠症候群 ,  日本人 ,  患者 ,  血小板凝集 ,  阻害 ,  心血管イベント ,  CYP2C19 ,  ACS ,  試験