清水健之

シミズタケユキ | Shimizu Takeyuki

所属機関・部署：
職名：准教授

研究分野 (3件)：免疫学 , 医化学 , 機能生物化学

研究キーワード (4件)：分子生物学 , 免疫学 , molecular biology , Immunology

競争的資金等の研究課題 (9件)：

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論文 (57件)：

Takeyuki Shimizu, Lin Sun, Kazuo Ohnishi. Influence of pre-B cell receptor deficiency on the immunoglobulin repertoires in peripheral blood B cells before and after immunization. Molecular Immunology. 2024. 166. 87-100
Gert-Jan Bekker, Nobutaka Numoto, Maki Kawasaki, Takahiro Hayashi, Saaya Yabuno, Yuko Kozono, Takeyuki Shimizu, Haruo Kozono, Nobutoshi Ito, Masayuki Oda, et al. Elucidation of binding mechanism, affinity and complex structure between mWT1 tumor-associated antigen peptide and HLA-A*24:02. Protein Science. 2023. 32. 10. e4775
Eiji Yuba, Yoshikatsu Sugahara, Yuta Yoshizaki, Takeyuki Shimizu, Michiyuki Kasai, Keiko Udaka, Kenji Kono. Carboxylated polyamidoamine dendron-bearing lipid-based assemblies for precise control of intracellular fate of cargo and induction of antigen-specific immune responses. Biomaterials Science. 2021. 9. 8. 3076-3089
Toshihiro Komatsu, Takeyuki Shimizu, Makoto Kanoh, Tomoya Miyakawa, Yoko Satta, Yoshiki Yasukochi, Rika Fujimoto, Motoki Tada, Kaori Machida, Sayo Kataoka, et al. Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion. Immunogenetics. 2020. 72. 3. 143-153
Tashiro Y, Murakami A, Hara Y, Shimizu T, Kubo M, Goitsuka R, Kishimoto H, Azuma T. High-affinity IgM⁺ memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen. Scientific Reports. 2018. 8. 1. 14559

MISC (41件)：

Y. Tashiro, A. Murakami, T. Shimizu, R. Goitsuka, H. Kishimoto, T. Azuma. High-affinity IgM(+) memory B cells are deficient in terminal differentiation potential to secrete IgM antibodies by restimulation with (4-hydroxy-3-nitrophenyl) acetyl-chicken gamma-globulin. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 1147-1147
TASHIRO Yasuyuki, MURAKAMI Akikazu, GOITSUKA Ryo, SHIMIZU Takeyuki, KISHIMOTO Hidehiro, AZUMA Takachika. An asymmetric antibody repertoire is shaped between plasmablasts and plasma cells after secondary immunization with (4-hydroxy-3-nitrophenyl)acetyl chicken γ-globulin. 日本免疫学会総会・学術集会記録. 2015. 44. Proceedings
TASHIRO Yasuyuki, HARA Yasushi, MURAKAMI Akikazu, SHIMIZU Takeyuki, AZUMA Takachika. Germinal center reaction actively induces somatic hypermutation in IgM but down-regulates class switch recombination. 日本免疫学会総会・学術集会記録. 2013. 42. Proceedings
西谷千明, 有木茂, 高橋素子, 栗村雄一郎, 斎藤充史, 長谷川喜弘, 清水健之, 黒木由夫. 酸化肺サーファクタントリン脂質によるLPS惹起炎症応答抑制機構. エンドトキシン・自然免疫研究. 2011. 14. 43-45
HARA Yasushi, MURAKAMI Akikazu, NISHIMURA Miyuki, SHIMIZU Takeyuki, AZUMA Takachika. T細胞依存性免疫応答に関与するIgM+記憶B細胞の解析. 日本免疫学会総会・学術集会記録. 2011. 40

講演・口頭発表等 (28件)：

Influences of pre-B cell receptor deficiency on repertoires of naive immunoglobulin heavy and light chains and of antigen-responding heavy chains in peripheral blood B cells
(第52回日本免疫学会学術集会 2024)
Antigen presentation and helper T cell activation by MHC class II-binding peptide immunization in a micelle formula
(第26回日本がん免疫学会総会 2022)
Efficient induction of effector T cells by peptide immunization in a micelle formula
(第25回日本がん免疫学会総会 2021)
ゲノム編集によるTAP欠損細胞を使ったMHCクラスI分子と抗原ペプチドの結合相互作用解析法
(第23回日本がん免疫学会総会 2019)
Construction of a TAP deficient HLA class I-binding assay system with the use of CRISPR/Cas9 system
(第46回日本免疫学会学術集会 2017)

学歴 (4件)：

学位 (1件)：

経歴 (11件)：

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所属学会 (7件)：

日本がん免疫学会 , 日本生化学会 , 日本免疫学会 , 日本分子生物学会 , The Japanese Biochemical Society , Japanese Society for Immunology , The Molecular Biology Society of Japan

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清水 健之