張功幸

ハリヨシユキ | Hari Yoshiyuki

所属機関・部署：
職名：教授
ホームページURL (1件)： http://p.bunri-u.ac.jp/lab06/index.html

研究分野 (2件)：薬系化学、創薬科学 , 生体化学

競争的資金等の研究課題 (8件)：

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論文 (114件)：

Yuta Ito, Hisato Tanaka, Ayana Murakami, Yasufumi Fuchi, Yoshiyuki Hari. Synthesis of fluorescent 5-heteroarylpyrimidine-containing oligonucleotides via post-synthetic trifluoromethyl conversion. Organic and Biomolecular Chemistry. 2024. 22. 17. 3510-3517
Yu Mikame, Honoka Eshima, Haruki Toyama, Juki Nakao, Misaki Matsuo, Tsuyoshi Yamamoto, Yoshiyuki Hari, Jun A Komano, Asako Yamayoshi. Development and Crosslinking Properties of Psoralen-Conjugated Triplex-Forming Oligonucleotides as Antigene Tools Targeting Genome DNA. ChemMedChem. 2023. 18. 21. e202300348
Yasufumi Fuchi, Miho Kawaguchi, Yuta Ito, Yoshiyuki Hari. Synthesis and Properties of 2′-Deoxyadenosine Mimics Bearing a Thieno[3,2- d ]pyrimidine Ring. Synlett. 2023. 35. 6. 716-720
Yuta Ito, Chisa Takemori, Yoshiyuki Hari. Chemical Conversion of 5-Fluoromethyl- and 5-Difluoromethyl-Uracil Bases in Oligonucleotides Using Postsynthetic Modification Strategy. Current Protocols in Nucleic Acid Chemistry. 2023. 3. 7. e837
Yasufumi Fuchi, Kouki Watanabe, Misa Shoji, Yuta Ito, Yoshiyuki Hari. Synthesis of purine derivatives of Me-TaNA and properties of Me-TaNA-modified oligonucleotides. Organic and Biomolecular Chemistry. 2023. 21. 25. 5203-5213

MISC (9件)：

Yuta Ito, Yoshiyuki Hari. Synthesis of Nucleobase-Modified Oligonucleotides by Post-Synthetic Modification in Solution. The Chemical Record. 2022. 22. 5. e202100325
Yoshiyuki Hari. Bridged Nucleosides as Building Blocks of Oligonucleotides: Synthesis and Properties. HETEROCYCLES. 2020. 100. 5. 681-717
張功幸. 二重鎖形成能(用語解説). Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2016. 74. 2. 169-169
架橋部に複数のヘテロ原子を有する2’,4’-架橋型人工核酸の合成と機能. Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2016. 74. 2. 141-153
Yoshiyuki Hari. Development of Artificial Nucleic Acid That Recognizes a CG Base Pair in Triplex DNA Formation. YAKUGAKU ZASSHI. 2013. 133. 11. 1201-1208

書籍 (7件)：

核酸科学ハンドブック
講談社 2020
2'-C,4'-C-Ethyleneoxy-bridged 2'-deoxyribonucleic acids (EoDNAs) with thymine nucleobases: Synthesis, duplex-forming ability and enzymatic stability
Humana Press 2019
2',4'-Bridged nucleic acids containing plural heteroatoms in the bridge moiety
Springer Singapore 2018
Site-specific modification of nucleobases in oligonucleotides
Springer Singapore 2018
2',4'-Bridged nucleic acids for targeting double-stranded DNA
Springer 2016

学歴 (2件)：

学位 (1件)：

経歴 (8件)：

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所属学会 (5件)：

日本化学会 , 日本核酸化学会 , 日本核酸医薬学会 , 有機合成化学協会 , 日本薬学会

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張 功幸