張功幸

ハリヨシユキ | Hari Yoshiyuki

所属機関・部署：
職名：教授
ホームページURL (1件)： http://p.bunri-u.ac.jp/lab06/index.html

研究分野 (2件)：薬系化学、創薬科学 , 生体化学

競争的資金等の研究課題 (8件)：

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論文 (116件)：

Misa Shoji, Yasufumi Fuchi, Yuta Ito, Yoshiyuki Hari. Synthesis and characterization of oligonucleotides containing 2′-O,4′-C-methyleneoxy-bridged 5-methyluridine with an unsubstituted bridge. Tetrahedron. 2024. 163
Yuta Ito, Hisato Tanaka, Ayana Murakami, Yasufumi Fuchi, Yoshiyuki Hari. Synthesis of fluorescent 5-heteroarylpyrimidine-containing oligonucleotides via post-synthetic trifluoromethyl conversion. Organic and Biomolecular Chemistry. 2024. 22. 17. 3510-3517
Yu Mikame, Honoka Eshima, Haruki Toyama, Juki Nakao, Misaki Matsuo, Tsuyoshi Yamamoto, Yoshiyuki Hari, Jun A Komano, Asako Yamayoshi. Development and Crosslinking Properties of Psoralen-Conjugated Triplex-Forming Oligonucleotides as Antigene Tools Targeting Genome DNA. ChemMedChem. 2023. 18. 21. e202300348
Yasufumi Fuchi, Miho Kawaguchi, Yuta Ito, Yoshiyuki Hari. Synthesis and Properties of 2′-Deoxyadenosine Mimics Bearing a Thieno[3,2- d ]pyrimidine Ring. Synlett. 2023. 35. 6. 716-720
Yuta Ito, Chisa Takemori, Yoshiyuki Hari. Chemical Conversion of 5-Fluoromethyl- and 5-Difluoromethyl-Uracil Bases in Oligonucleotides Using Postsynthetic Modification Strategy. Current Protocols in Nucleic Acid Chemistry. 2023. 3. 7. e837

MISC (9件)：

Yuta Ito, Yoshiyuki Hari. Synthesis of Nucleobase-Modified Oligonucleotides by Post-Synthetic Modification in Solution. The Chemical Record. 2022. 22. 5. e202100325
Yoshiyuki Hari. Bridged Nucleosides as Building Blocks of Oligonucleotides: Synthesis and Properties. HETEROCYCLES. 2020. 100. 5. 681-717
張功幸. 二重鎖形成能(用語解説). Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2016. 74. 2. 169-169
架橋部に複数のヘテロ原子を有する2’,4’-架橋型人工核酸の合成と機能. Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2016. 74. 2. 141-153
Yoshiyuki Hari. Development of Artificial Nucleic Acid That Recognizes a CG Base Pair in Triplex DNA Formation. YAKUGAKU ZASSHI. 2013. 133. 11. 1201-1208

書籍 (7件)：

核酸科学ハンドブック
講談社 2020
2'-C,4'-C-Ethyleneoxy-bridged 2'-deoxyribonucleic acids (EoDNAs) with thymine nucleobases: Synthesis, duplex-forming ability and enzymatic stability
Humana Press 2019
2',4'-Bridged nucleic acids containing plural heteroatoms in the bridge moiety
Springer Singapore 2018
Site-specific modification of nucleobases in oligonucleotides
Springer Singapore 2018
2',4'-Bridged nucleic acids for targeting double-stranded DNA
Springer 2016

学歴 (2件)：

学位 (1件)：

経歴 (8件)：

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所属学会 (5件)：

日本化学会 , 日本核酸化学会 , 日本核酸医薬学会 , 有機合成化学協会 , 日本薬学会

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張 功幸