矢田弘史

ヤダコウジ | YADA KOJI

所属機関・部署：

研究分野 (1件)：胎児医学、小児成育学

研究キーワード (3件)：遺伝子 , 凝固異常症 , 血友病

競争的資金等の研究課題 (5件)：

2021 - 2024 血友病A患者・保因者の第VIII因子遺伝子型に基づく病態解析と新規個別化治療戦略の開発
2018 - 2021 中等症・軽症血友病Aにおける第VIII因子の凝血学的特性に基づく新規治療戦略の開発
2017 - 2020 血友病A分子病態の解明と第VIII因子高機能化に関する研究
2015 - 2018 インヒビター保有軽症血友病Aの凝血学的特性と新規治療戦略に関する基礎的研究
2013 - 2015 インヒビター保有血友病A患者の新たな止血治療戦略における凝血学的基礎研究

論文 (43件)：

Koji Yada, Natsume Fujitate, Kenichi Ogiwara, Tetsuhiro Soeda, Takehisa Kitazawa, Keiji Nogami. Reduced plasma factor X is associated with a lack of response to recombinant activated factor VII in patients with hemophilia A and inhibitor, but does not impair emicizumab-driven hemostasis in vitro. Thrombosis Research. 2024. in press
Yuya Mawarikado, Asuka Sakata, Yusuke Inagaki, Suguru Harada, Kohei Tatsumi, Naoki Matsumoto, Kenichi Ogiwara, Koji Yada, Yasushi Yoshimura, Akira Kido, et al. Force-sensing treadmill gait analysis system can detect gait abnormalities in haemophilia patients without arthropathy. Haemophilia : the official journal of the World Federation of Hemophilia. 2024
Koji Yada, Kenichi Ogiwara, Naruto Shimonishi, Yuto Nakajima, Tetsuhiro Soeda, Takehisa Kitazawa, Keiji Nogami. Emicizumab-mediated hemostatic function assessed by thrombin generation assay in an in vitro model of factor VIII-depleted thrombophilia plasma. International journal of hematology. 2024. 119. 2. 109-118
Naruto Shimonishi, Kana Sasai, Kenichi Ogiwara, Shoko Furukawa, Yuto Nakajima, Kuniyoshi Mizumachi, Koji Yada, Masahiro Takeyama, Midori Shima, Narumi Mizuno, et al. Longitudinal dynamic changes in factor VIII inhibitor titers in patients with hemophilia A and inhibitors receiving emicizumab prophylaxis. International journal of hematology. 2023. 118. 6. 690-698
Masahiro Takeyama, Naoki Matsumoto, Hiroto Abe, Suguru Harada, Kenichi Ogiwara, Shoko Furukawa, Naruto Shimonishi, Yuto Nakajima, Koji Yada, Tetsuhiro Soeda, et al. Coagulant potentials of emicizumab in the plasmas from infant and toddler patients with hemophilia A. Pediatric blood & cancer. 2023. 70. 10. e30590

MISC (10件)：

Yuto Nakajima, Naruto Shimonishi, Koji Yada, Shoko Furukawa, Kenichi Ogiwara, Masahiro Takeyama, Keiji Nogami. Usefulness of a Microchip Flow-Chamber System Assay for Screening Congenital Primary Hemostasis Disorders. PEDIATRIC BLOOD & CANCER. 2021. 68
Yuto Nakajima, Koji Yada, Keiji Nogami, Midori Shima. A Novel Mechanism of Factor VIIa/Tissue Factor (TF)-Catalyzed Activation and Inactivation of B-Domain-Deleted Factor VIII in the Early Initiation Phases of Coagulation. BLOOD. 2018. 132
Koji Yada, Keiji Nogami, Yuto Nakajima, Midori Shima. Predictors of the Outcome of Immune Tolerance Induction (ITI) Therapy Among Japanese Pediatric Hemophilia A Patients with F8 Null Mutations. PEDIATRIC BLOOD & CANCER. 2017. 64. S29-S30
Yasuko Furuichi, Koji Yada, Satoko Nezu, Norio Kurumatani, Mitsuru Nakajima, Seiji Kinoshita, Keiji Nogami, Midori Shima. Health-related Quality of Life in Children with Hemophilia Assessed by J-KIDSCREEN-52. PEDIATRIC BLOOD & CANCER. 2017. 64. S30-S30
Koji Yada, Keiji Nogami, Takehisa Kitazawa, Kunihiro Hattori, Midori Shima. ACE910 Facilitates Its Hemostatic Effect with the Lower Concentration of Factor X Than That Required for Factor VIIa-Driven Coagulation. BLOOD. 2015. 126. 23

特許 (2件)：

学位 (1件)：

博士(医学) (奈良県立医科大学)

受賞 (6件)：

2019/06 - 日本血栓止血学会優秀演題賞 J-HIS研究からみた日本における血友病A患者のF8 遺伝子変異の実態とインヒビター発生との関連
2016/07 - 公立大学法人奈良県立医科大学学術研究奨励会第23回中島佐一学術研究奨励賞インヒビター保有血友病Aの病態解明と新規治療戦略確立に関する研究
2015/11 - 奈良県医師会奈良県医師会学術奨励賞インヒビター保有血友病A患者に対する新規治療戦略に関する基礎的研究
2014/12 - 米国血液学会 ASH Abstract Award Factor Va inactivation by activated protein C predominantly contributes to the downregulation of coagulation rather than factor VIIIa inactivation
2011/07 - 国際血栓止血学会 / 日本血栓止血学会 JSTH Asian-Pacific Scholarship Mild bleeding tendency in a severe hemophilia A with Arg1781His substitution associated with acceleration of factor Xa generation

全件表示

所属学会 (5件)：

日本遺伝カウンセリング学会 , 日本血栓止血学会 , 日本血液学会 , 日本小児血液・がん学会 , 日本小児科学会

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矢田 弘史

矢田弘史