鍔田武志

ツバタタケシ | Tsubata Takeshi

所属機関・部署：
職名：客員教授
ホームページURL (1件)： http://www.tmd.ac.jp/imm/index.html

研究分野 (2件)：医化学 , 免疫学

研究キーワード (9件)：ワクチン , 活性酸素 , 細胞内輸送 , アポトーシス , 感染免疫 , 自己免疫 , 糖鎖抗原 , 抗体 , 免疫応答

競争的資金等の研究課題 (70件)：

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論文 (181件)：

Chizuru Akatsu, Yuko Naito-Matsui, Hajjaj H.M. Abdu-Allah, Akihiro Imamura, Wang Long, Hideharu Ishida, Hiromu Takematsu, Takeshi Tsubata. Neu5Gc-mediated high affinity interaction is dispensable for CD22 cis-ligands to regulate B cell signaling. Journal of Biological Chemistry. 2024. 107630-107630
Chizuru Akatsu, Takahiro Tsuneshige, Nobutaka Numoto, Wang Long, Toshio Uchiumi, Yoshikatsu Kaneko, Masatake Asano, Nobutoshi Ito, Takeshi Tsubata. CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody. Journal of autoimmunity. 2024. 146. 103245-103245
Takeshi Tsubata. Siglec cis-ligands and their roles in the immune system. Glycobiology. 2023
Zi-Xian Wang, Yi-Qian Pan, Xuexin Li, Takeshi Tsubata, Rui-Hua Xu. Immunotherapy in gastrointestinal cancers: advances, challenges, and countermeasures. Science bulletin. 2023. 68. 8. 763-766
Yuki Suganuma, Akihiro Imamura, Hiromune Ando, Makoto Kiso, Hiromu Takematsu, Takeshi Tsubata, Hideharu Ishida. Improved synthesis of CD22-binding sialosides and its application for further development of potent CD22 inhibitors. Glycoconjugate journal. 2023. 40. 2. 225-246

MISC (54件)：

Tsubata Takeshi. Inhibitory B cell co-receptors and autoimmune diseases. Immunological Medicine. 2019. 42. 3. 108-116
Tsubata T. CD72 is a Negative Regulator of B Cell Responses to Nuclear Lupus Self-antigens and Development of Systemic Lupus Erythematosus. Immune network. 2019. 19. 1. e1
Tsubata Takeshi. Ligand Recognition Determines the Role of Inhibitory B Cell Co-receptors in the Regulation of B Cell Homeostasis and Autoimmunity. Frontiers in Immunology. 2018. 9. 2276
鍔田武志. 抑制性B細胞レセプターCD72と自己免疫疾患 (特集 B細胞の分化と機能制御). 臨床免疫・アレルギー科. 2013. 60. 2. 130-136
Michiko Shimoda, Anna Bolduc, Domonica Powell, Yutetsu Ametani, Mayuko Takezaki, Stephen Nutt, Masahito Kamanaka, Richard Flavell, Andrew Mellor, Takeshi Tsubata, et al. A critical role of dendritic cells in CD8 T cell IL-10 expression during inflammatory response triggered by CD40-activated B cells. JOURNAL OF IMMUNOLOGY. 2012. 188

特許 (2件)：

書籍 (40件)：

B細胞と自己免疫疾患
臨床免疫・アレルギー科73(5)562-570,科学評論社 2020
Involvement of reactive oxygen species (ROS) in BCR signaling as a second messenger. In “B Cells in Immunity and Tolerance” ed. by Ji-Yang Wang
Springer 2020
Identification of Siglec Cis-ligands by Proximity Labeling. In “Lectin Purification and Analysis: Methods and Protocols” ed. by Jun Hirabayashi
Springer 2020
Lectin Purification and Analysis: Methods and Protocols:Identification of Siglec Cis-ligands by Proximity Labeling.
Springer 2020
Development of Siglec Regulators. In “Glycoscience: Basic Science to Applications” (ed. by Naoyuki Taniguchi, Tamao Endo, Jun Hirabayashi, Shoko Nishihara, Kenji Kadomatsu, Kazunari Akiyoshi and Kiyoko F. Aoki-Kinoshita)
Springer 2019 ISBN:9811358559

講演・口頭発表等 (313件)：

補体経路と免疫システムのクロストーク
(第57回日本補体学会学術集会 2021)
Immunogenic Peptides Derived from SARS-CoV2
(19th Sugadai Symposium 2021)
Molecular mechanism of self-antigen recognition by the ligand binding domain of B cell inhibitory co-receptor CD72
(25TH Congress and General Assembly of the International Union of Crystallography 2021)
CD72による死細胞へのB細胞自己免疫応答の抑制
(第29回日本Cell Death学会学術集会 2021)
ギラン・バレー症候群関連遺伝子rare variantと自己免疫応答
(第20回釧路ニューロサイエンスワークショップ 2021)

学歴 (2件)：

学位 (1件)：

経歴 (14件)：

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委員歴 (19件)：

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受賞 (5件)：

2021/06 - 第85回日本インターフェロン・サイトカイン学会学術集会ベストプレゼンテーション賞/銅賞(Amin Alborzian Deh Sheikh) A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides
2018/12 - 日本免疫学会ベストプレゼンテーション賞 (Xuexin, Li)
2017/10 - ドイツ研究振興協会オイゲン・ウント・イルゼ・ザイボルト賞
2005 - ドイツ連邦共和国大統領フィリップ・フランツ・フォン・シーボルト賞
1996 - 日本生化学会日本生化学会奨励賞

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鍔田 武志