文献

J-GLOBAL ID：201202205641212545   整理番号：12A1524425

In vitroおよびin vivoでの内皮細胞に対する新規NADPHオキシダーゼ阻害剤のPECAM標的デリバリーによる抗酸化保護

Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo

著者 (18件)： HOOD Elizabeth D. (Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School of Medicine, Philadelphia, PA 19104, USA) ,  HOOD Elizabeth D. (Inst. for Translational Medicine and Therapeutics, Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School ...) ,  GREINEDER Colin F. (Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School of Medicine, Philadelphia, PA 19104, USA) ,  GREINEDER Colin F. (Inst. for Translational Medicine and Therapeutics, Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School ...) ,  DODIA Chandra (Inst. for Environmental Medicine Univ. of Pennsylvania, The Perelman School of Medicine, Philadelphia, PA 19104, USA) ,  HAN Jingyan (Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School of Medicine, Philadelphia, PA 19104, USA) ,  HAN Jingyan (Inst. for Translational Medicine and Therapeutics, Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School ...) ,  MESAROS Clementina (Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School of Medicine, Philadelphia, PA 19104, USA) ,  MESAROS Clementina (Inst. for Translational Medicine and Therapeutics, Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School ...) ,  MESAROS Clementina (Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, Dep. of Pharmacology, Univ. of ...) ,  SHUVAEV Vladimir V. (Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School of Medicine, Philadelphia, PA 19104, USA) ,  SHUVAEV Vladimir V. (Inst. for Translational Medicine and Therapeutics, Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School ...) ,  BLAIR Ian A. (Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School of Medicine, Philadelphia, PA 19104, USA) ,  BLAIR Ian A. (Inst. for Translational Medicine and Therapeutics, Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School ...) ,  BLAIR Ian A. (Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, Dep. of Pharmacology, Univ. of ...) ,  FISHER Aron B. (Inst. for Environmental Medicine Univ. of Pennsylvania, The Perelman School of Medicine, Philadelphia, PA 19104, USA) ,  MUZYKANTOV Vladimir R. (Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School of Medicine, Philadelphia, PA 19104, USA) ,  MUZYKANTOV Vladimir R. (Inst. for Translational Medicine and Therapeutics, Dep. of Pharmacology, Univ. of Pennsylvania, The Perelman School ...)
資料名： Journal of Controlled Release  (Journal of Controlled Release)
巻： 163  号： 2  ページ： 161-169  発行年： 2012年10月28日 
JST資料番号： C0308D  ISSN： 0168-3659  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 血管内腔を覆う内皮細胞において産生される活性酸素種(ROS)...

シソーラス用語： ヒト ,...
準シソーラス用語： 抗酸化療法 ,...

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分類 (2件)： 製剤一般  (GY02010Z) ,  研究開発  (GU01040N)

物質索引 (1件)： グリセロりん酸

引用文献 (45件)：

• E. Simone, B.S. Ding, V. Muzykantov, Targeted delivery of therapeutics to endothelium, Cell Tissue Res. 335 (2009) 283-300.
• S. Muro, C. Garnacho, J.A. Champion, J. Leferovich, C. Gajewski, E.H. Schuchman, S. Mitragotri, V.R. Muzykantov, Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers, Mol. Ther. 16 (2008) 1450-1458.
• V.V. Shuvaev, M.A. Ilies, E. Simone, S. Zaitsev, Y. Kim, S. Cai, A. Mahmud, T. Dziubla, S. Muro, D.E. Discher, V.R. Muzykantov, Endothelial targeting of antibody-decorated polymeric filomicelles, ACS Nano 5 (2011) 6991-6999.
• P.N. Reynolds, K.R. Zinn, V.D. Gavrilyuk, I.V. Balyasnikova, B.E. Rogers, DJ. Buchsbaum, M.H. Wang, DJ. Miletich, W.E. Grizzle, J.T. Douglas, S.M. Danilov, D.T. Curiel, A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo, Mol. Ther. 2 (2000) 562-578.
• E.N. Atochina, I.V. Balyasnikova, S.M. Danilov, D.N. Granger, A.B. Fisher, V.R. Muzykantov, Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress, Am. J. Physiol. 275 (1998) L806-L817.

タイトルに関連する用語 (6件)： 内皮細胞 ,  NADPHオキシダーゼ ,  阻害剤 ,  PECAM ,  標的デリバリー ,  酸化