文献

J-GLOBAL ID：201302299743477448   整理番号：13A1888387

子宮内電気穿孔法による筋萎縮性側索硬化症関連蛋白質TDP-43の特徴を調査するための独自マウスモデル

A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation

著者 (9件)： AKAMATSU Megumi (Dep. of Neurology, Fac. of Medicine, Univ. of Tsukuba, JPN) ,  TAKUMA Hiroshi (Dep. of Neurology, Fac. of Medicine, Univ. of Tsukuba, JPN) ,  YAMASHITA Takenari (Div. of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine ...) ,  OKADA Takuya (Dep. of Molecular Neurobiology, Fac. of Medicine, Univ. of Tsukuba, JPN) ,  KEINO-MASU Kazuko (Dep. of Molecular Neurobiology, Fac. of Medicine, Univ. of Tsukuba, JPN) ,  ISHII Kazuhiro (Dep. of Neurology, Fac. of Medicine, Univ. of Tsukuba, JPN) ,  KWAK Shin (Div. of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine ...) ,  MASU Masayuki (Dep. of Molecular Neurobiology, Fac. of Medicine, Univ. of Tsukuba, JPN) ,  TAMAOKA Akira (Dep. of Neurology, Fac. of Medicine, Univ. of Tsukuba, JPN)
資料名： Neuroscience Research  (Neuroscience Research)
巻： 77  号： 4  ページ： 234-241  発行年： 2013年12月 
JST資料番号： D0210C  ISSN： 0168-0102  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： TDP-43は,筋萎縮性側索硬化症(ALS)患者の大脳皮質お...

シソーラス用語： 遺伝子導入 ,...
準シソーラス用語： TDP-43遺伝子 ,...

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分類 (3件)： 神経の基礎医学  (GN01020W) ,  中枢神経系  (EJ12030F) ,  実験用生物  (EA03070Y)

引用文献 (31件)：

• Arai, T., Hasegawa, M., Akiyama, H., Ikeda, K., Nonaka, T., Mori, H., Mann, D., Tsuchiya, K., Yoshida, M., Hashizume, Y., Oda, T., 2006. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochemical and Biophysical Research Communications 351 (3), 602-611.
• Arai, T., Hasegawa, M., Nonoka, T., Kametani, F., Yamashita, M., Hosokawa, M., Niizato, K., Tsuchiya, K., Kobayashi, Z., Ikeda, K., Yoshida, M., Onaya, M., Fujishiro, H., Akiyama, H., 2010. Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy. Neuropathology: Official Journal of the Japanese Society of Neuropathology 30(2), 170-181.
• Arnold, E.S., Ling, S.C., Huelga, S.C., Lagier-Tourenne, C., Polymenidou, M., Ditsworth, D., Kordasiewicz, H.B., McAlonis-Downes, M., Platoshyn, O., Parone, P.A., Da Cruz, S., Clutario, K.M., Swing, D., Tessarollo, L, Marsala, M., Shaw, C.E., Yeo, G.W., Cleveland, D.W., 2013. ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proceedings of the National Academy of Sciences of the United States of America 110 (8), E736-E745.
• Baloh, R.H., 2011. TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. The FEBS Journal 278 (19), 3539-3549.
• Bao, Y.P., Cook, L.J., O'Donovan, D., Uyama, E., Rubinsztein, D.C., 2002. Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy. The Journal of Biological Chemistry 277 (14), 12263-12269.

タイトルに関連する用語 (7件)： 子宮 ,  電気穿孔法 ,  筋萎縮性側索硬化症 ,  蛋白質 ,  TDP-43 ,  調査 ,  マウスモデル