飯村信

イイムラシン | Shin Iimura

所属機関・部署：
職名：主査

研究分野 (1件)：薬系化学、創薬科学

論文 (22件)：

Jean-Marc Lapierre, Sudharshan Eathiraj, David Vensel, Yanbin Liu, Cathy O. Bull, Susan Cornell-Kennon, Shin Iimura, Eugene W. Kelleher, Darin E. Kizer, Steffi Koerner, et al. Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor. JOURNAL OF MEDICINAL CHEMISTRY. 2016. 59. 13. 6455-6469
Shinji Tanaka, Tadashi Toki, Mika Yokoyama, Hiroki Shimizu, Tomonori Yamasaki, Yoshiyuki Yoneda, Fumihito Muro, Takanori Yasukochi, Shin Iimura, Kaoru Morishita. A Novel Inhibitor of I-KappaB Kinase Beta Ameliorates Experimental Arthritis through Downregulation of Proinflammatory Cytokines in Arthritic Joints. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2014. 37. 1. 87-95
Masaki Setoguchi, Shin Iimura, Yuuichi Sugimoto, Yoshiyuki Yoneda, Jun Chiba, Toshiyuki Watanabe, Fumihito Muro, Yutaka Iigo, Gensuke Takayama, Mika Yokoyama, et al. A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid. BIOORGANIC & MEDICINAL CHEMISTRY. 2013. 21. 1. 42-61
Masaki Setoguchi, Shin Iimura, Yuuichi Sugimoto, Yoshiyuki Yoneda, Jun Chiba, Toshiyuki Watanabe, Fumihito Muro, Yutaka Iigo, Gensuke Takayama, Mika Yokoyama, et al. Identification of trans-4-[1-[[ 7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist. BIOORGANIC & MEDICINAL CHEMISTRY. 2012. 20. 3. 1201-1212
Shimizu H, Yamasaki T, Yoneda Y, Muro F, Hamada T, Yasukochi T, Tanaka S, Toki T, Yokoyama M, Morishita K, et al. Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: exploration of effective compounds in arthritis models. Bioorganic & medicinal chemistry letters. 2011. 21. 15. 4550-4555

MISC (2件)：

Nobuo Machinaga, Shin Iimura, Yuuichi Sugimoto, Yoshiyuki Yoneda, Jun Chiba, Toshiyuki Watanabe, Fumihito Muro, Masaki Setoguchi, Atsushi Nakayama. Discovery of DW-908: An orally potent and exquisitely selective VLA-4 antagonist. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2009. 238
M SEKINE, S IIMURA, K FURUSAWA. SYNTHESIS OF A NEW CLASS OF 2'-PHOSPHORYLATED OLIGORIBONUCLEOTIDES CAPABLE OF CONVERSION TO OLIGORIBONUCLEOTIDES. JOURNAL OF ORGANIC CHEMISTRY. 1993. 58. 11. 3204-3208

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