文献

J-GLOBAL ID：201402268333266118   整理番号：14A0896790

マウスにおける4-(ヒドロキシメチルニトロソアミノ)-1-(3-ピリジル)-1-ブタノングルクロニド(4-(メチルニトロソアミノ)-1-(3-ピリジル)-1-ブタノンから生成された反応中間体の安定した形状の形成および安定性

Formation and stability of 4-(hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide, a stable form of reactive intermediate produced from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, in mice

著者 (10件)： NISHIYAMA Takahito (Dep. of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  HAYASHI Nahoko (Dep. of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  KAKURAI Naoki (Dep. of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  YANAGITA Hiromi (Dep. of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  KURIYAMA Ai (Dep. of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  MIYAMOTO Chika (Dep. of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  ISHIHARA Yumi (Dep. of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  OGURA Kenichiro (Dep. of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  OHNUMA Tomokazu (Dep. of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  HIRATSUKA Akira (Dep. of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences)
資料名： Journal of Toxicological Sciences  (Journal of Toxicological Sciences)
巻： 39  号： 4  ページ： 515-521 (J-STAGE)  発行年： 2014年 
JST資料番号： Z0265B  ISSN： 0388-1350  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： 4-(メチルニトロソアミノ)-1-(3-ピリジル)-1-ブタ...

シソーラス用語： *反応中間体 ,...
準シソーラス用語： 造腫瘍性【tumorigenicity】 ,...

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分類 (1件)： 有機化合物の毒性  (GZ02030Y)

物質索引 (2件)： 1-(3-ピリジル)-4-((β-D-グルコピラノシルオキシメチル)(ニトロソ)アミノ)-1-ブタノン ,  NNK

引用文献 (16件)：

• Buckley, D.B. and Klaassen, C.D. (2006): Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice. Drug Metab. Dispos., 35, 121-127.
• Buckley, D.B. and Klaassen, C.D. (2009): Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2. Drug Metab. Dispos., 37, 847-856.
• Chen, G., Dellinger, R.W., Sun, D., Spratt, T.E. and Lazarus, P. (2008): Glucuronidation of tobacco-specific nitrosamines by UGT2B10. Drug Metab. Dispos., 36, 824-830.
• Devereux, T.R., Belinsky, S.A., Maronpot, R.R., White, C.M., Hegi, M.E., Patel, A.C., Foley, J.F., Greenwell, A. and Anderson, M.W. (1993): Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains. Mol. Carcinog., 8, 177-185.
• Hecht, S.S., Trushin, N., Reid-Quinn, C.A., Burak, E.S., Jones, A.B., Southers, J.L., Gombar, C.T., Carmella, S.G., Anderson, L.M. and Rice, J.M. (1993): Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites. Carcinogenesis, 14, 229-236.

タイトルに関連する用語 (6件)： マウス ,  ピリジル ,  1-ブタノン ,  グルクロニド ,  反応中間体 ,  安定性