文献

J-GLOBAL ID：201602247569797160   整理番号：16A0643998

Srcは膵臓β細胞においてグルコキナーゼの細胞内局在に影響することでインスリン分泌とグルコース代謝を調節する

Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β-cells

著者 (14件)： Sato Hiroki (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Nagashima Kazuaki (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Ogura Masahito (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Sato Yuichi (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Tahara Yumiko (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Ogura Kasane (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Yamano Gen (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Sugizaki Kazu (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Fujita Naotaka (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Tatsuoka Hisato (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Usui Ryota (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Mukai Eri (Department of Medical Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Fujimoto Shimpei (Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Nankoku, Japan) ,  Inagaki Nobuya (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan)
資料名： Journal of Diabetes Investigation (Web)  (Journal of Diabetes Investigation (Web))
巻： 7  号： 2  ページ： 171-178  発行年： 2016年 
JST資料番号： U0507A  ISSN： 2040-1124  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 目的/諸言:Srcは非受容体型チロシンキナーゼで,広範囲の細...

シソーラス用語： 内分泌細胞 ,...
準シソーラス用語： 膵臓β細胞

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著者キーワード (3件)： Glucokinase ,  Insulin secretion ,  Src

分類 (1件)： 代謝異常・栄養性疾患一般  (GD05010J)

引用文献 (43件)：

• Maechler P, Wollheim CB. Mitochondrial function in normal and diabetic β-cells. Nature 2001; 414: 807-812.
• Montane J, Cadavez L, Novials A. Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes. Diabetes Metab Syndr Obes 2014; 7: 25-34.
• Fujimoto S, Mukai E, Inagaki N. Role of endogenous ROS production in impaired metabolism-secretion coupling of diabetic pancreatic β cells. Prog Biophys Mol Biol 2011; 107: 304-310.
• Kominato R, Fujimoto S, Mukai E, et al. Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain treated rat pancreatic islets. Diabetologia 2008; 51: 1226-1235.
• Mukai E, Fujimoto S, Sato H, et al. Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner. Diabetes 2011; 60: 218-226.

タイトルに関連する用語 (7件)： SRC ,  膵臓β細胞 ,  グルコキナーゼ ,  細胞内局在 ,  インスリン分泌 ,  グルコース代謝 ,  調節