文献

J-GLOBAL ID：201602288658486131   整理番号：16A1134129

メトトレキサートは破骨細胞前駆体へのRANKL誘導カルシウム流入の低下により破骨細胞形成を阻害する

Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors

著者 (19件)： Kanagawa Hiroya (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Masuyama Ritsuko (Department of Molecular Bone Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan) ,  Morita Mayu (Department of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Sato Yuiko (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Sato Yuiko (Department of Musculoskeletal Reconstruction and Regeneration Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Niki Yasuo (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Kobayashi Tami (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Katsuyama Eri (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Fujie Atsuhiro (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Hao Wu (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Tando Toshimi (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Watanabe Ryuichi (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Miyamoto Kana (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Morioka Hideo (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Matsumoto Morio (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Toyama Yoshiaki (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Saya Hideyuki (Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Miyamoto Takeshi (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Miyamoto Takeshi (Department of Integrated Bone Metabolism and Immunology, Keio University School of Medicine, Tokyo, Japan)
資料名： Journal of Bone and Mineral Metabolism  (Journal of Bone and Mineral Metabolism)
巻： 34  号： 5  ページ： 526-531  発行年： 2016年 
JST資料番号： L0163A  ISSN： 0914-8779  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 骨粗鬆症患者数の増加は,世界中で喫緊の課題である。骨粗鬆症は...

シソーラス用語： *酵素阻害剤 ,...
準シソーラス用語： 薬剤スクリーニング ,...

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著者キーワード (4件)： Methotrexate ,  Osteoclast ,  Differentiation ,  Calcium influx

分類 (2件)： 運動器系の基礎医学  (GG01020B) ,  免疫療法薬・血液製剤の基礎研究  (GW22010D)

物質索引 (1件)： メトトレキサート

引用文献 (26件)：

• Reginster JY, Burlet N (2006) Osteoporosis: a still increasing prevalence. Bone 38:4-9
• Jaffe N, Paed D, Farber S, Traggis D, Geiser C, Kim BS, Das L, Frauenberger G, Djerassi I, Cassady JR (1973) Favorable response of metastatic osteogenic sarcoma to pulse high-dose methotrexate with citrovorum rescue and radiation therapy. Cancer 31:1367-1373
• Bleyer WA (1978) The clinical pharmacology of methotrexate: new applications of an old drug. Cancer 41:36-51
• Cope AP (2008) T cells in rheumatoid arthritis. Arthritis Res Ther 10:1
• Kremer JM, Lee JK (1986) The safety and efficacy of the use of methotrexate in long-term therapy for rheumatoid arthritis. Arthritis Rheum 29:822-831

タイトルに関連する用語 (8件)： メトトレキサート ,  破骨細胞 ,  前駆体 ,  RANKL ,  誘導 ,  カルシウム流入 ,  破骨細胞形成 ,  阻害