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J-GLOBAL ID：201702212836949891   整理番号：17A1973518

調節性T細胞のSlc3a2を仲介する分枝鎖アミノ酸依存的維持【Powered by NICT】

Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells

著者 (33件)： Ikeda Kayo (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Ikeda Kayo (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Ikeda Kayo (Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan) ,  Kinoshita Makoto (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Kinoshita Makoto (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Kayama Hisako (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Kayama Hisako (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Nagamori Shushi (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Nagamori Shushi (Laboratory of Biomolecular Dynamics, Department of Collaborative Research, Nara Medical University, Nara, Japan) ,  Kongpracha Pornparn (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Kongpracha Pornparn (Laboratory of Biomolecular Dynamics, Department of Collaborative Research, Nara Medical University, Nara, Japan) ,  Umemoto Eiji (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Umemoto Eiji (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Okumura Ryu (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Okumura Ryu (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Kurakawa Takashi (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Kurakawa Takashi (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Murakami Mari (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Murakami Mari (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Murakami Mari (Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan) ,  Mikami Norihisa (Department of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Shintani Yasunori (Department of Medical Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan) ,  Ueno Satoko (Fundamental Technology Laboratory, Institute for Innovation, Ajinomoto Co., Inc., Kawasaki, Japan) ,  Andou Ayatoshi (Innovation Promotion Department, Research Institute, EA Pharma Co., Ltd., Kawasaki, Japan) ,  Ito Morihiro (Department of Microbiology, College of Life and Health Science, Chubu University, Aichi, Japan) ,  Tsumura Hideki (Division of Animal Resources, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Yasutomo Koji (Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan) ,  Ozono Keiichi (Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan) ,  Takashima Seiji (Department of Medical Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan) ,  Sakaguchi Shimon (Department of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Kanai Yoshikatsu (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Takeda Kiyoshi (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Takeda Kiyoshi (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan)
資料名： Cell Reports  (Cell Reports)
巻： 21  号： 7  ページ： 1824-1838  発行年： 2017年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 免疫応答を抑制する,Foxp3~+調節性T(T_reg)細胞はin vivoで高度に増殖。しかし,T_reg細胞の活発な複製はin vivoで維持されているかは不明のままである。,イソロイシンを含む,分岐鎖アミノ酸(BCAA)はアミノ酸輸送体Slc3a2依存性代謝リプログラミングを介したT_reg細胞の増殖状態の維持に必要であることを示した。BCAA減少飼料を給与したマウスは,不完全なin vivo増殖能とFoxp3~+T_reg細胞数の減少を示した。マウスはFoxp3~+T_reg細胞障害in vivo複製とT_reg細胞数の減少を示したに特異的にSlc3a2を欠いていた。Slc3a2欠損T_reg細胞はmTORC1経路と変化した代謝状態の障害イソロイシン誘導活性化を示した。Slc3a2変異マウスはin vivoでT_reg細胞のイソロイシン誘導増加を示さず,多臓器炎症を示した。総合すれば,これらの結果は,BCAAはSlc3a2依存性代謝調節を介してT_reg細胞の維持を制御することを示した。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 内臓 ,  *分枝鎖アミノ酸 ,  複製 ,  炎症 ,  *制御性T細胞 ,  細胞計数 ,  免疫反応 ,  代謝調節 ,  代謝 ,  脂肪族アミン ,  脂肪族カルボン酸 ,  第一アミン
準シソーラス用語： mTORC1 ,  細胞障害 ,  増殖能 ,  リプログラミング ,  アミノ酸輸送体 , 【Automatic Indexing@JST】

著者キーワード (5件)： T_reg細胞 ,  アミノ酸 ,  免疫代謝 ,  免疫調節 ,  transporter

分類 (1件)： 免疫反応一般  (ED03010T)

物質索引 (1件)： イソロイシン

タイトルに関連する用語 (3件)： 調節性T細胞 ,  仲介 ,  分枝鎖アミノ酸