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J-GLOBAL ID：201702225638039520   整理番号：17A1718111

マウスにおける急性肝障害時における共生Lactobacillus制御免疫寛容【Powered by NICT】

Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice

著者 (29件)： Nakamoto Nobuhiro (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Amiya Takeru (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Amiya Takeru (Research Unit/Frontier Therapeutic Sciences, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa 2270033, Japan) ,  Aoki Ryo (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Aoki Ryo (Institute of Health Science, Ezaki Glico Co., Ltd., Osaka 5558502, Japan) ,  Taniki Nobuhito (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Koda Yuzo (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Koda Yuzo (Research Unit/Frontier Therapeutic Sciences, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa 2270033, Japan) ,  Miyamoto Kentaro (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Miyamoto Kentaro (Miyarisan Pharmaceutical Co., Ltd., Research Laboratory, Tokyo 1140016, Japan) ,  Teratani Toshiaki (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Suzuki Takahiro (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Chiba Sayako (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Chu Po-Sung (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Hayashi Atsushi (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Hayashi Atsushi (Miyarisan Pharmaceutical Co., Ltd., Research Laboratory, Tokyo 1140016, Japan) ,  Yamaguchi Akihiro (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Shiba Shunsuke (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Miyake Rei (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Katayama Tadashi (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Suda Wataru (Department of Microbiology, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Suda Wataru (Laboratory of Metagenomics, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 2778561, Japan) ,  Mikami Yohei (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Kamada Nobuhiko (Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA) ,  Ebinuma Hirotoshi (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan) ,  Saito Hidetsugu (Division of Pharmacotherapeutics, Keio University School of Pharmacy, Tokyo 1058512, Japan) ,  Hattori Masahira (Laboratory of Metagenomics, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 2778561, Japan) ,  Hattori Masahira (Cooperative Major in Advanced Health Science, Graduate School of Advanced Science and Engineering, Faculty of Science and Engineering, Waseda University, Tokyo 1698555, Japan) ,  Kanai Takanori (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan)
資料名： Cell Reports  (Cell Reports)
巻： 21  号： 5  ページ： 1215-1226  発行年： 2017年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 腸管由来の微生物抗原は急性肝障害時の先天性免疫反応を誘発する。回復時に調節免疫は炎症を抑制する役割を果たすが,この過程の基礎となる正確な機構は不明のままである。ここでは,免疫調節古典的樹状細胞(cDCs)の動員はコンカナバリンA誘導急性肝障害における肝耐性に重要であることを見出した。急性肝障害は,腸における共生Lactobacillusの濃縮をもたらした。注目すべきことに,Lactobacillusを腸の自然リンパ系細胞によるIL-22産生を活性化し,全身IL 22レベルを上昇させた。腸管由来IL 22は粘膜バリア機能を促進し,肝臓への調節cDCsの動員を促進した。これらcDCsはTLR9活性化を介してIL-10およびTGF-βを産生し,さらに肝臓炎症を防止した。まとめると,本結果は,有益な腸微生物は肝臓における免疫寛容誘発性免疫応答に影響することを示す。,腸内微生物叢の調節は肝臓耐性を調節する潜在的選択肢になる可能性がある。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 樹状細胞 ,  抗原 ,  TGFβ ,  コンカナバリンA ,  腸内微生物 ,  肝炎 ,  リンパ球 ,  *免疫トレランス ,  *乳酸桿菌属 ,  自然免疫 ,  インターロイキン10 ,  粘膜
準シソーラス用語： バリア機能 ,  インターロイキン22 ,  *急性肝不全 , 【Automatic Indexing@JST】

著者キーワード (8件)： 免疫寛容 ,  樹状細胞 ,  自然リンパ系細胞 ,  急性肝障害 ,  インターロイキン-10 ,  インターロイキン22 ,  microbiota ,  腸内共生バランス失調

分類 (2件)： 消化器の基礎医学  (GH01020E) ,  消化器の診断  (GH02000P)

タイトルに関連する用語 (5件)： マウス ,  急性肝障害 ,  共生 ,  Lactobacillus ,  免疫寛容