文献

J-GLOBAL ID：201702241064678533   整理番号：17A0972341

双極性障害におけるミトコンドリアDNAポリメラーゼ遺伝子(POLG1)の有害変異のエンリッチメント

Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder

著者 (21件)： Kasahara Takaoki (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Ishiwata Mizuho (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Kakiuchi Chihiro (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Fuke Satoshi (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Iwata Nakao (Faculty of Medicine, Department of Psychiatry, Fujita Health University, Japan) ,  Ozaki Norio (Faculty of Medicine, Department of Psychiatry, Nagoya University, Nagoya, Japan) ,  Kunugi Hiroshi (Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Minabe Yoshio (Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Nakamura Kazuhiko (Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Iwata Yasuhide (Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Fujii Kumiko (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Fujii Kumiko (Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan) ,  Kanba Shigenobu (Department of Psychiatry, Kyushu University School of Medicine, Fukuoka, Japan) ,  Ujike Hiroshi (Department of Psychiatry, Okayama University School of Medicine, Okayama, Japan) ,  Kusumi Ichiro (Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan) ,  Kataoka Muneko (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Matoba Nana (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Takata Atsushi (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Iwamoto Kazuya (Department of Molecular Brain Science, Graduate School of Medicine, Kumamoto University, Kumamoto, Japan) ,  Yoshikawa Takeo (Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan) ,  Kato Tadafumi (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan)
資料名： Psychiatry and Clinical Neurosciences  (Psychiatry and Clinical Neurosciences)
巻： 71  号： 8  ページ： 518-529  発行年： 2017年08月 
JST資料番号： W1032A  ISSN： 1323-1316  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オーストラリア (AUS)  言語： 英語 (EN)

抄録/ポイント： 目的:通常の複合疾患で遺伝子の’ダークマター’の実質的な部分...

シソーラス用語： *DNAポリメラーゼ ,...
準シソーラス用語： *遺伝子変異 ,...

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著者キーワード (5件)： bipolar disorder ,  mitochondrial dysfunction ,  POLG ,  POLG1 ,  rare variants

分類 (1件)： 精神科の基礎医学  (GR01020I)

引用文献 (44件)：

• Merikangas KR, Jin R, He JP et al. Prevalence and correlates of bipolar spectrum disorder in the World Mental Health Survey Initiative. Arch. Gen. Psychiatry 2011; 68: 241-251.
• Kawakami N. Large-scale epidemiological study on the prevalence of mental disorders: World Mental Health Japan Survey. A report of the Health Labour Sciences Research Grant from The Ministry of Health Labour and Welfare. 2014 (in Japanese).
• Kato T. Whole genome/exome sequencing in mood and psychotic disorders. Psychiatry Clin. Neurosci. 2015; 69: 65-76.
• Kerner B. Toward a deeper understanding of the genetics of bipolar disorder. Front. Psychiatry 2015; 6: 105.
• Chen DT, Jiang X, Akula N et al. Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Mol. Psychiatry 2013; 18: 195-205.

タイトルに関連する用語 (5件)： 双極性障害 ,  ミトコンドリア ,  DNAポリメラーゼ ,  遺伝子 ,  変異