文献

J-GLOBAL ID：201702248334799608   整理番号：17A0552221

CYP2C76欠失はカニクイサルにおいて胚性致死である:CYP2C76の初期胚形成に果たす潜在的役割

CYP2C76 deficiency is embryonic lethal in cynomolgus macaques: The potential role of CYP2C76 in early embryogenesis

著者 (18件)： Koyama Shuzo (Drug Safety Research Center (DSR), Shin Nippon Biomedical Laboratories (SNBL), Ltd., Kagoshima, Japan) ,  Koyama Shuzo (SNBL USA, Ltd., Everett, WA, USA) ,  Fukuda Koji (Drug Safety Research Center (DSR), Shin Nippon Biomedical Laboratories (SNBL), Ltd., Kagoshima, Japan) ,  Fukuda Koji (SNBL USA, Ltd., Everett, WA, USA) ,  Watanabe Sho (Drug Safety Research Center (DSR), Shin Nippon Biomedical Laboratories (SNBL), Ltd., Kagoshima, Japan) ,  Watanabe Sho (SNBL USA, Ltd., Everett, WA, USA) ,  Matsushita Akinori (Drug Safety Research Center (DSR), Shin Nippon Biomedical Laboratories (SNBL), Ltd., Kagoshima, Japan) ,  Matsushita Akinori (Pharmacokinetics and Bioanalysis Center (PBC), Shin Nippon Biomedical Laboratories (SNBL), Ltd., Kainan, Japan) ,  Tsuchiya Hideaki (Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Japan) ,  Fujinami Nahoko (Graduate School of Biology-Oriented Science and Technology, Kinki University, Kinokawa, Japan) ,  Kohara Sakae (Pharmacokinetics and Bioanalysis Center (PBC), Shin Nippon Biomedical Laboratories (SNBL), Ltd., Kainan, Japan) ,  Murayama Norie (Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan) ,  Nagano Masashi (Laboratory of Theriogenology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan) ,  Yamazaki Hiroshi (Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan) ,  Fukuzaki Koichiro (Drug Safety Research Center (DSR), Shin Nippon Biomedical Laboratories (SNBL), Ltd., Kagoshima, Japan) ,  Fukuzaki Koichiro (SNBL USA, Ltd., Everett, WA, USA) ,  Uno Yasuhiro (Pharmacokinetics and Bioanalysis Center (PBC), Shin Nippon Biomedical Laboratories (SNBL), Ltd., Kainan, Japan) ,  Hosoi Yoshihiko (Graduate School of Biology-Oriented Science and Technology, Kinki University, Kinokawa, Japan)
資料名： Drug Metabolism and Pharmacokinetics (Web)  (Drug Metabolism and Pharmacokinetics (Web))
巻： 32  号： 1  ページ： 112-115  発行年： 2017年02月 
JST資料番号： U0705A  ISSN： 1347-4367  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： カニクイザルは薬剤代謝研究において重要な霊長類種である;しか...

シソーラス用語： *チトクロームP450 ,...
準シソーラス用語： CYP2C ,...

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著者キーワード (5件)： Cytochrome P450 ,  Embryogenesis ,  Progesterone ,  Null allele ,  Cynomolgus macaque

分類 (4件)： 薬物の物理化学的性質  (GV01060M) ,  性ホルモン  (EB08050O) ,  酵素一般  (EB09010D) ,  婦人科・産科の基礎医学  (GS01020L)

物質索引 (1件)： プロゲステロン

引用文献 (17件)：

• Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics 2004;14:1-18.
• Goldstein JA. Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br J Clin Pharmacol 2001;52:349-55.
• Uno Y, Fujino H, Kito G, Kamataki T, Nagata R. CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone. Mol Pharmacol 2006;70:477-86.
• Uehara S, Murayama N, Nakanishi Y, Zeldin DC, Yamazaki H, Uno Y. Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys. J Pharmacol Exp Ther 2011;339:654-61.
• Uno Y, Kumano T, Kito G, Nagata R, Kamataki T, Fujino H. CYP2C76-mediated species difference in drug metabolism: a comparison of pitavastatin metabolism between monkeys and humans. Xenobiotica 2007;37:30-43.

タイトルに関連する用語 (5件)： 欠失 ,  胚性致死 ,  初期 ,  胚形成 ,  役割