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【目的】肝細胞癌(HCC)ラットモデルにおける腫瘍抑制および肝機能に及ぼす半肝血流遮断法の影響を観察する。方法:30匹の健康なラットを無作為にPringle完全遮断対照群、半肝遮断群、半肝血流遮断群の各10匹に分けた。【方法】H22肝細胞癌のモデルを確立するために門脈を用いて,肝細胞癌モデルを確立し,そして,3日後にラットの肝血流を遮断し,そして,5日後に再潅流した。血清アラニンアミノトランスフェラーゼ(ALT)、アスパラギン酸アミノトランスフェラーゼ(AST)、アルブミン(ALB)含有量と肝臓組織のスーパーオキシドジスムターゼ(SOD)、マロンジアルデヒド(MDA)のレベルを測定し、肝細胞のアポトーシス率と腫瘍抑制率を計算した。結果:半肝遮断群と半肝血流遮断群におけるALTとASTの含有量は,対照群におけるそれらより有意に低かった。ALBは,対照群[(70.97±8.62)]と比較して(268.26±46.39)IU/L,(386.86±50.28),(29.54±2.16)対(28.29±2.13)g/L,t=13.222,8.048,4.430,13.151,8.087,3.393,P=0.001,0.008,0.018,0.000,0.008,0.024,P<0.01であった。.・・・..... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . (392.53±22.47)対(392.53±22.47)(P<0.001)。肝臓組織におけるSODの発現は,対照群より有意に高かった。MDA,肝細胞のアポトーシス率は,対照群[(152.32±16.21)対(148.47±15.24)対(89.12±9.45)U/mg],(14.36±1.45)%,(14.35±1.45)%,(14.35±1.45)%,t=10.651,15.552,13.018,P=0.001,0.001および0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001,0.001;肝遮断群と半肝血流遮断群の腫瘍の質は,対照群[(1.83±0.32)対(1.90±0.35)対(2.62±0.41)g,t=4.803,4.224,P=0.008,0.018]より有意に低かった。半肝血流遮断群と半肝遮断群のALT、AST、SOD、MDA、肝細胞アポトーシス率、ラット腫瘍の質量、腫瘍抑制率に有意差が認められなかった。結論:半肝血流遮断法は肝臓癌モデルラットの肝臓虚血再灌流障害を軽減し、腫瘍抑制効果を増強し、手術安全性は半肝遮断法より高い。Data from Wanfang. Translated by JST【JST・京大機械翻訳】
