文献

J-GLOBAL ID：201702259746524649   整理番号：17A1363207

腫瘍微小環境におけるインターロイキン-6の欠如は1型免疫を増強し,癌免疫療法の有効性を高める

Lack of interleukin-6 in the tumor microenvironment augments type-1 immunity and increases the efficacy of cancer immunotherapy

著者 (17件)： Ohno Yosuke (Division of Functional Immunology, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan) ,  Ohno Yosuke (Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan) ,  Toyoshima Yujiro (Division of Functional Immunology, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan) ,  Toyoshima Yujiro (Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan) ,  Yurino Hideaki (Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Monma Norikazu (DNA Data Analysis Laboratory, National Institute of Genetics, Mishima, Japan) ,  Xiang Huihui (Division of Functional Immunology, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan) ,  Sumida Kentaro (Division of Functional Immunology, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan) ,  Kaneumi Shun (Division of Functional Immunology, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan) ,  Terada Satoshi (Division of Functional Immunology, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan) ,  Hashimoto Shinichi (Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Ikeo Kazuho (DNA Data Analysis Laboratory, National Institute of Genetics, Mishima, Japan) ,  Homma Shigenori (Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan) ,  Kawamura Hideki (Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan) ,  Takahashi Norihiko (Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan) ,  Taketomi Akinobu (Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan) ,  Kitamura Hidemitsu (Division of Functional Immunology, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan)
資料名： Cancer Science (Web)  (Cancer Science (Web))
巻： 108  号： 10  ページ： 1959-1966  発行年： 2017年 
JST資料番号： U0505A  ISSN： 1349-7006  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 腫瘍微小環境における免疫抑制の克服は効果的な癌免疫療法にとっ...

シソーラス用語： 環境 ,...
準シソーラス用語： ポリI-C ,...

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著者キーワード (5件)： 細胞傷害性T細胞 ,  樹状細胞 ,  インターフェロン-γ ,  インターロイキン-6 ,  programmed deathリガンド1

分類 (2件)： 基礎腫よう学一般  (GE02010R) ,  消化器の腫よう  (GH04000D)

引用文献 (30件)：

• Hodi FS, O'Day SJ, McDermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010; 363: 711-23.
• Wolchok JD, Kluger H, Callahan MK et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013; 369: 122-33.
• Brahmer JR, Tykodi SS, Chow LQM et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012; 366: 2455-65.
• Palucka K, Banchereau J. Cancer immunotherapy via dendritic cells. Nat Rev Cancer 2012; 12: 265-77.
• Palucka K, Banchereau J. Dendritic-cell-based therapeutic cancer vaccines. Immunity 2013; 39: 38-48.

タイトルに関連する用語 (7件)： 腫瘍微小環境 ,  インターロイキン-6 ,  欠如 ,  免疫 ,  増強 ,  癌免疫療法 ,  有効性