文献

J-GLOBAL ID：201702265088824368   整理番号：17A0135717

アコニターゼとイソクエン酸デヒドロゲナーゼの異常活性化を通じたマウス骨髄の鉄誘発後成的異常

Iron-induced epigenetic abnormalities of mouse bone marrow through aberrant activation of aconitase and isocitrate dehydrogenase

著者 (14件)： Yamamoto Masayo (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Tanaka Hiroki (Department of Gastrointestinal Immunology and Regenerative Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Tanaka Hiroki (Department of Legal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Toki Yasumichi (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Hatayama Mayumi (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Ito Satoshi (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Addo Lynda (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Shindo Motohiro (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Sasaki Katsunori (Department of Gastrointestinal Immunology and Regenerative Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Ikuta Katsuya (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Ohtake Takaaki (International University of Health and Welfare Hospital, Nasu-shiobara, Tochigi, Japan) ,  Fujiya Mikihiro (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Torimoto Yoshihiro (Oncology Center, Asahikawa Medical University Hospital, Asahikawa, Hokkaido, Japan) ,  Kohgo Yutaka (International University of Health and Welfare Hospital, Nasu-shiobara, Tochigi, Japan)
資料名： International Journal of Hematology  (International Journal of Hematology)
巻： 104  号： 4  ページ： 491-501  発行年： 2016年10月 
JST資料番号： F0888A  ISSN： 0925-5710  CODEN： IJHEEY  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 鉄過負荷は骨髄異形成症候群(MDS)患者で懸念があるままであ...

シソーラス用語： *骨髄異形成症候群 ,...
準シソーラス用語： アコニターゼ1

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著者キーワード (4件)： Myelodysplastic syndrome ,  Leukemia ,  DNA methylation ,  Iron overload

分類 (1件)： 血液の基礎医学  (GK01020N)

物質索引 (1件)： 2-ヒドロキシグルタル酸

引用文献 (41件)：

• List AF, Sandberg AA, Doll DC. Myelodysplastic Syndromes. In: Greer JP, Foerster J, Lukens JN, Rodgers GM, Paraskevas F, Glader B, editors. Wintrobe’s clinical hematology. 11th ed. Philadlphia: Lippincott Williams & Wilkins; 2004. p. 2207-34.
• Shlush LI, Zandi S, Itzkovitz S, Schuh AC. Aging, clonal hematopoiesis and preleukemia: not just bad luck? Int J Hematol. 2015;102:513-22.
• Takatoku M, Uchiyama T, Okamoto S, Kanakura Y, Sawada K, Tomonaga M, et al. Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality. Eur J Haematol. 2007;78:487-94.
• Neukirchen J, Fox F, Kündgen A, Nachtkamp K, Strupp C, Haas R, et al. Improved survival in MDS patients receiving iron chelation therapy-a matched pair analysis of 188 patients from the Düsseldorf MDS registry. Leuk Res. 2012;36:1067-70.
• Rose C, Brechignac S, Vassilief D, Pascal L, Stamatoullas A, Guerci A, et al. GFM (Groupe Francophone des Myélodysplasies). Does iron chelation therapy improve survival in regularly transfused lower risk MDS patients? A multicenter study by the GFM (Groupe Francophone des Myélodysplasies). Leuk Res. 2010;34:864-70.

タイトルに関連する用語 (7件)： アコニターゼ ,  イソクエン酸デヒドロゲナーゼ ,  活性化 ,  マウス ,  骨髄 ,  鉄 ,  誘発