文献

J-GLOBAL ID：201702275892865899   整理番号：17A1945696

トランスフェクトされた哺乳類細胞におけるhERG蛋白質のピルジカイニド誘導安定化の基礎をなす分子機構

Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells

著者 (20件)： Onohara Takeshi (Division of Organ Regeneration Surgery, Tottori University Faculty of Medicine, Yonago, Japan) ,  Hisatome Ichiro (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Kurata Yasutaka (Department of Physiology II, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, Japan) ,  Li Peili (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Notsu Tomomi (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Morikawa Kumi (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Otani Naoyuki (Department of Pharmacology, Dokkyo Medical College, Tochigi, Japan) ,  Yoshida Akio (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Iitsuka Kazuhiko (Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, Nishichou 36-1, Yonago, Japan) ,  Kato Masaru (Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, Nishichou 36-1, Yonago, Japan) ,  Miake Junichiro (Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, Nishichou 36-1, Yonago, Japan) ,  Ninomiya Haruaki (Department of Biological Regulation, Tottori University Faculty of Medicine, Nishichou 36-1, Yonago, Japan) ,  Higaki Katsumi (Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, Nishichou 36-1, Yonago, Japan) ,  Shirayoshi Yasuaki (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Nishihara Takashi (Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan) ,  Nishihara Takashi (Center for Research on Green Sustainable Chemistry, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan) ,  Itoh Toshiyuki (Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan) ,  Itoh Toshiyuki (Center for Research on Green Sustainable Chemistry, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan) ,  Nakamura Yoshinobu (Division of Organ Regeneration Surgery, Tottori University Faculty of Medicine, Yonago, Japan) ,  Nishimura Motonobu (Division of Organ Regeneration Surgery, Tottori University Faculty of Medicine, Yonago, Japan)
資料名： Journal of Arrhythmia (Web)  (Journal of Arrhythmia (Web))
巻： 33  号： 3  ページ： 226-233  発行年： 2017年 
JST資料番号： U1150A  ISSN： 1880-4276  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 背景:比較的選択的なNa+チャネルブロッカーに分類されるピル...

シソーラス用語： 培養細胞 ,...
準シソーラス用語： Akt/蛋白質キナーゼB ,...

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著者キーワード (3件)： ピルジカイニド ,  hERG ,  化学シャペロン

分類 (2件)： 心臓作用薬の基礎研究  (GW07020N) ,  循環系の基礎医学  (GJ01020K)

物質索引 (1件)： ピルジカイニド

引用文献 (21件)：

• Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 1995;81:299-307.
• Surawicz B. Electrophysiologic substrate of torsade de pointes: dispersion of repolarization or early afterdepolarizations? J Am Coll Cardiol 1989;14:172-84.
• Li P, Ninomiya H, Kurata Y, et al. Reciprocal control of hERG stability by hsp70 and hsc70 with implication for restoration of LQT2 mutant stability. Circ Res 2011;108:458-68.
• Gordo-Gilart R, Andueza S, Hierro L, Jara P, Alvarez L. Functional rescue of trafficking-impaired ABCB4 mutants by chemical chaperones. PLoS One 2016;11:e0150098.
• Zhang KP, Yang BF, Li BX. Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects. Acta Pharmacol Sin 2014;35:1473-84.

タイトルに関連する用語 (8件)： 哺乳類細胞 ,  HERG ,  蛋白質 ,  ピルジカイニド ,  誘導 ,  安定化 ,  基礎 ,  分子機構