研究キーワード (4件):
Protein quality control
, Translational pausing
, Unfolded protein response
, オルガネラの恒常性
競争的資金等の研究課題 (7件):
2022 - 2026 核-ミトコンドリアキメラ複合体のみなしご解消法
2022 - 2025 オルガネラ量ホメオスタシスの根底原理の解明
2022 - 2023 タンパク質分泌増強細胞の創出に向けた小胞体量制御原理の解明
2019 - 2022 オルガネラ量の恒常性を保つシステムの根底原理の解明
2012 - 2015 膜脂質の異常による小胞体ストレスとその感知メカニズム
2011 - 2012 オルガネラノックダウン法の開発を契機としたオルガネラ量補償機構の解析
2007 - 2012 異常タンパク質応答の生理的役割の解明
全件表示
論文 (19件):
Hiroshi Kadokura, Nanshi Harada, Satoshi Yamaki, Naoya Hirai, Ryusuke Tsukuda, Kota Azuma, Yuta Amagai, Daisuke Nakamura, Kota Yanagitani, Hideki Taguchi, et al. Development of luciferase-based highly sensitive reporters that detect ER-associated protein biogenesis abnormalities. iScience. 2024. 111189-111189
Ashuei Sogawa, Ryota Komori, Kota Yanagitani, Miku Ohfurudono, Akio Tsuru, Koji Kadoi, Yukio Kimata, Hiderou Yoshida, Kenji Kohno. Signal sequence-triage is activated by translocon obstruction sensed by an ER stress sensor IRE1α. Cell structure and function. 2023. 48. 2. 211-221
Nascent chain-mediated localization of mRNA on the endoplasmic reticulum as an important step of unfolded protein response.
Springer 2014 ISBN:9784431550518
講演・口頭発表等 (8件):
Mammalian cells evacuate mitochondrial DNA from mitophagy-dependent degradation under HIF1 activation
(Keystone Symposium “Mitochondrial Dysfunction: From Ultra-Rare Diseases to Aging”, Colorado, USA 2023)
ミトコンドリア不足に対する細胞応答
(第95回日本生化学会大会 2022)
Unusual ubiquitination system in quality control of cytosolic proteins
(Ubiquitin Club Meeting 2015)