文献

J-GLOBAL ID：201802223621579871   整理番号：18A1785526

トランスデューシンβ様1,X連鎖,および核受容体共レプレッサーは甲状腺ホルモン受容体によるTRH及びTSHβ遺伝子プロモーターのリガンド非依存性刺激を協同的に増強する

Transducin β-like 1, X-linked and nuclear receptor co-repressor cooperatively augment the ligand-independent stimulation of TRH and TSHβ gene promoters by thyroid hormone receptors

著者 (20件)： Takamizawa Tetsuya (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Satoh Tetsurou (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Miyamoto Tomoko (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Nakajima Yasuyo (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Ishizuka Takahiro (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Tomaru Takuya (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Yoshino Satoshi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Katano-Toki Akiko (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Nishikido Ayaka (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Sapkota Santosh (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Watanabe Takuya (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Okamura Takashi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Ishida Emi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Horiguchi Kazuhiko (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Matsumoto Syunichi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Ishii Sumiyasu (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Ozawa Atsushi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Shibusawa Nobuyuki (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Okada Shuichi (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Yamada Masanobu (Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan)
資料名： Endocrine Journal (Web)  (Endocrine Journal (Web))
巻： 65  号： 8  ページ： 805-813(J-STAGE)  発行年： 2018年 
JST資料番号： U1479A  ISSN： 1348-4540  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： レチノイン酸と甲状腺ホルモン受容体コレプレッサー複合体の核受...

シソーラス用語： ヒト ,...
準シソーラス用語： TSHβサブユニット ,...

ログイン（無料）して見る     続きはJDreamIII（有料）にて  {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A1785526&from=J-GLOBAL&jstjournalNo=U1479A") }}

著者キーワード (6件)： 甲状腺機能低下症 ,  トランスデューシンβ様1 ,  Xリンク ,  共レプレッサー ,  TRH ,  TSHβ

分類 (3件)： 内分泌系の基礎医学  (GL01020Q) ,  生物学的機能  (EB03040U) ,  遺伝的変異  (EC01030Y)

引用文献 (22件)：

• 1 Yamada M, Mori M (2008) Mechanisms related to the pathophysiology and management of central hypothyroidism. Nat Clin Pract Endocrinol Metab 4: 638-694.
• 2 Collu R, Tang J, Castagne J, Lagace G, Masson N, et al. (1997) A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene. J Clin Endocr Metab 82: 1561-1565.
• 3 Sun Y, Bak B, Schoenmakers N, van Trotsenburg AS, Oostdijk W, et al. (2012) Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement. Nat Genet 44: 1375-1381.
• 4 Yamada M, Saga Y, Shibusawa N, Hirato J, Murakami M, et al. (1997) Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene. Proc Natl Acad Sci U S A 94: 10862-10867.
• 5 Yamada M, Shibusawa N, Ishii S, Horiguchi K, Umezawa R, et al. (2006) Prolactin secretion in mice with thyrotropin-releasing hormone deficiency. Endocrinology 147: 2591-2596.

タイトルに関連する用語 (12件)： トランスデューシン ,  核受容体 ,  レプレッサー ,  甲状腺ホルモン受容体 ,  TRH ,  TSH ,  遺伝子プロモーター ,  リガンド ,  非依存性 ,  刺激 ,  協同 ,  増強