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J-GLOBAL ID：201802253158828250   整理番号：18A1802080

MFGE8多型は中国人におけるメタボリックシンドロームよりも代謝関連指標と有意に関連する:ネスト症例対照研究【JST・京大機械翻訳】

MFGE8 polymorphisms are significantly associated with metabolism-related indicators rather than metabolic syndrome in Chinese people: A nested case-control study

著者 (42件)： Liu Leilei (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Leilei (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Leilei (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Cheng Cheng (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Cheng Cheng (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Cheng Cheng (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Dongdong (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Dongdong (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Dongdong (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Ruiyuan (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Ruiyuan (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Yu (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Sun Xizhuo (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Yin Zhaoxia (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Li Honghui (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhao Yang (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhao Yang (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Wang Bingyuan (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Wang Bingyuan (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Ren Yongcheng (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Ren Yongcheng (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Xuejiao (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Xuejiao (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Dechen (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Dechen (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Feiyan (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Feiyan (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Chen Xu (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Chen Xu (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhou Qionggui (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhou Qionggui (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Xiong Yihan (Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Xu Qihuan (Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Jiali (Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Hong Shihao (Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  You Ziyang (Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Hu Dongsheng (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Hu Dongsheng (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Hu Dongsheng (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Ming (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Ming (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Ming (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China)
資料名： Gene  (Gene)
巻： 677  ページ： 176-181  発行年： 2018年 
JST資料番号： E0701B  ISSN： 0378-1119  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 乳脂肪球-上皮成長因子8(MFGE8)とメタボリックシンドローム(MetS)および代謝関連指標の一塩基多型(SNP)間の相関は限られている。本研究は中国人成人における関係を調査した。著者らは,MetSを有する408人の人々とベースライン性,年齢(±2歳),結婚状態,および居住村をマッチさせた408人の対照を含む,中国の中国コホート研究に基づくネスト化症例対照研究を実施した。SNPスキャン遺伝子タイピングシステムを用いて,4つの多型を選択し,遺伝子型を決定した。条件付きロジスティック回帰を用いて,MetS発生率とMFGE8多型の関連を推定し,線形回帰を用いて,対照における代謝関連指標との関連を評価した。著者らは,MetS発生または収縮期血圧またはトリグリセリドレベルまたは空腹時血漿グルコース(P>0.05)とMFGE8SNPの有意な関連性を見つけなかった。しかしながら,MFGE8 rs4932450は,優性モデル(β=-0.0218,P=0.007)および添加モデル(β=-0.0175,P=0.012)下で高密度リポ蛋白質コレステロール(HDL-C)レベルと負に関連し,劣性モデル下で拡張期血圧(DBP)と正に相関した(β=4.8848,P=0.011)。rs3784751SNPは,対照(β=0.0307,P=0.028)における胴囲(WC)の増加と関連していた。MFGE8多型はMetSと関連していなかったが,中国人成人におけるDBP,HDL-Cレベル,およびWCに関連していた。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 成人 ,  *代謝 ,  *メタボリックシンドローム ,  *症例対照研究 ,  優性 ,  コホート研究 ,  走査 ,  遺伝子型 ,  乳脂肪 ,  一塩基多型 ,  劣性 ,  トリグリセリド
準シソーラス用語： ウエスト周囲径 ,  ロジスティック回帰分析 ,  *中国人 , 【Automatic Indexing@JST】

著者キーワード (5件)： メタボリックシンドローム ,  代謝関連指標 ,  MFGE8 ,  多形 ,  入れ子型症例対照研究

分類 (2件)： 遺伝的変異  (EC01030Y) ,  代謝異常・栄養性疾患一般  (GD05010J)

タイトルに関連する用語 (7件)： 多型 ,  中国人 ,  メタボリックシンドローム ,  代謝 ,  指標 ,  ネスト ,  症例対照研究