文献

J-GLOBAL ID：201802263820734603   整理番号：18A0339472

O_2~およびH_2O_2~媒介破壊Fe代謝の薬理学的アスコルビン酸への非小細胞肺癌とGBM癌細胞の異なる感受性の原因となる【Powered by NICT】

O₂ ^- and H₂O₂-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

著者 (35件)： Schoenfeld Joshua D. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Sibenaller Zita A. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Mapuskar Kranti A. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Wagner Brett A. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Cramer-Morales Kimberly L. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Furqan Muhammad (Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Sandhu Sonia (Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Carlisle Thomas L. (Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Smith Mark C. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Abu Hejleh Taher (Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Berg Daniel J. (Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Zhang Jun (Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Keech John (Department of Surgery, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Parekh Kalpaj R. (Department of Surgery, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Bhatia Sudershan (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Monga Varun (Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Bodeker Kellie L. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Ahmann Logan (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Vollstedt Sandy (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Brown Heather (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Shanahan Kauffman Erin P. (Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Schall Mary E. (Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Hohl Ray J. (Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Clamon Gerald H. (Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Greenlee Jeremy D. (Department of Neurosurgery, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Howard Matthew A. (Department of Neurosurgery, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Shultz Michael K. (Department of Radiology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Smith Brian J. (Departmet of Biostatistics, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Riley Dennis P. (Galera Therapeutics, Malvern, PA 19355, USA) ,  Domann Frederick E. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Cullen Joseph J. (Department of Surgery, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Buettner Garry R. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Buatti John M. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Spitz Douglas R. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA) ,  Allen Bryan G. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA)
資料名： Cancer Cell  (Cancer Cell)
巻： 31  号： 4  ページ： 487-500.e8  発行年： 2017年 
JST資料番号： W1844A  ISSN： 1535-6108  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 放射線と化学療法と組み合わせた場合,薬理学的アスコルビン酸は潜在的抗癌剤として提案されている。アスコルビン酸の抗癌効果は,H_2O_2の定常状態量の増加をもたらすアスコルビン酸の自動酸化を含むと仮定されているが,癌細胞選択的毒性の機構(s)は未知のままである。O_2~およびH_2O_2のレベルの増加をもたらす癌細胞ミトコンドリア酸化的代謝の変化は細胞内鉄代謝を破壊すること,それによって酸化還元活性の不安定な鉄とH_2O_2を含む酸化促進化学によるアスコルビン酸への非小細胞肺癌(NSCLC)と神経膠芽腫(GBM)細胞を敏感にする選択的にできることを示した。添加では,前臨床試験と臨床試験は,実現可能性,選択毒性,忍容性,およびGBMとNSCLC治療における薬理学的アスコルビン酸の潜在的有効性を実証した。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 抗腫瘍薬 ,  抗腫瘍作用 ,  臨床試験 ,  薬物療法 ,  *感受性 ,  *薬理学 ,  *鉄 ,  *腫瘍細胞 ,  *代謝 ,  *非小細胞肺癌 ,  ミトコンドリア ,  酸化還元反応 ,  ラクトン ,  水溶性ビタミン ,  第二アルコール ,  ポリオール
準シソーラス用語： 鉄代謝 , 【Automatic Indexing@JST】

著者キーワード (10件)： 薬理学的アスコルビン酸 ,  肺非小細胞癌 ,  多形性膠芽腫 ,  酸化ストレス ,  不安定鉄代謝 ,  過酸化水素 ,  超酸化物 ,  スーパーオキシドジスムターゼ ,  トランスフェリン受容体 ,  フェリチン

分類 (2件)： 呼吸器の腫よう  (GI04000G) ,  腫ようの薬物療法  (GE03032C)

物質索引 (1件)： アスコルビン酸

タイトルに関連する用語 (9件)： 破壊 ,  Fe ,  代謝 ,  薬理学 ,  アスコルビン酸 ,  非小細胞肺癌 ,  癌細胞 ,  感受性 ,  原因