文献

J-GLOBAL ID：201802294056482102   整理番号：18A1493593

ラットの外傷-出血性ショック誘発急性肺損傷に対するトラネキサム酸の抗炎症効果

Anti-inflammatory effect of tranexamic acid against trauma-hemorrhagic shock-induced acute lung injury in rats

著者 (9件)： Teng Yue (Department of Emergency Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, P.R. China) ,  Teng Yue (Department of Emergency Medicine, General Hospital of Shenyang Military Area Command, 83 Wenhua Road, Shenyang 110016, P.R. China) ,  Feng Cong (Department of Emergency Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, P.R. China) ,  Liu Yunen (Department of Emergency Medicine, General Hospital of Shenyang Military Area Command, 83 Wenhua Road, Shenyang 110016, P.R. China) ,  Liu Yunen (Laboratory of Rescue Center for Severe Wound and Trauma PLA, 83 Wenhua Road, Shenyang 110016, P.R. China) ,  Liu Yunen (Liaoning Key Laboratory of Severe Wound and Trauma and Organ Protection, 83 Wenhua Road, Shenyang 110016, P.R. China) ,  Jin Hongxu (Department of Emergency Medicine, General Hospital of Shenyang Military Area Command, 83 Wenhua Road, Shenyang 110016, P.R. China) ,  Gao Yan (Department of Emergency Medicine, General Hospital of Shenyang Military Area Command, 83 Wenhua Road, Shenyang 110016, P.R. China) ,  Li Tanshi (Department of Emergency Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, P.R. China)
資料名： Experimental Animals  (Experimental Animals)
巻： 67  号： 3  ページ： 313-320(J-STAGE)  発行年： 2018年 
JST資料番号： Z0755A  ISSN： 1341-1357  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： リジンの合成誘導体であるトラネキサム酸(TXA)が,外傷-出...

シソーラス用語： ラット ,...
準シソーラス用語： PARP-1 ,...

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著者キーワード (5件)： 急性肺損傷 ,  出血性ショック ,  炎症 ,  NF-κB ,  トラネキサム酸

分類 (4件)： 生化学一般  (EB01000O) ,  呼吸器の基礎医学  (GI01020H) ,  消炎薬の基礎研究  (GW15010T) ,  細胞生理一般  (EF02010S)

物質索引 (1件)： トラネキサム酸

引用文献 (33件)：

• 1. Ananthakrishnan P., Cohen D.B., Xu D.Z., Lu Q., Feketeova E., and Deitch E.A. 2005. Sex hormones modulate distant organ injury in both a trauma/hemorrhagic shock model and a burn model. Surgery 137: 56-65.
• 2. Baker R.G., Hayden M.S., and Ghosh S. 2011. NF-κB, inflammation, and metabolic disease. Cell Metab. 13: 11-22.
• 3. Botha A.J., Moore F.A., Moore E.E., Sauaia A., Banerjee A., and Peterson V.M. 1995. Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failure. J. Trauma 39: 411-417.
• 4. Boudreau R.M., Johnson M., Veile R., Friend L.A., Goetzman H., Pritts T.A., Caldwell C.C., Makley A.T., and Goodman M.D. 2017. Impact of tranexamic acid on coagulation and inflammation in murine models of traumatic brain injury and hemorrhage. J. Surg. Res. 215: 47-54.
• 5. Burck R. 2004. Challenges of treating on the basis of knowledge: The ARDS Network trials and the ensuing controversy. Crit. Care Med. 32: 904-905.

タイトルに関連する用語 (7件)： ラット ,  外傷 ,  出血性ショック ,  誘発 ,  急性肺損傷 ,  トラネキサム酸 ,  抗炎症効果