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J-GLOBAL ID：201902220410487003   整理番号：19A2278352

腸透過性とIgAは心血管炎症に関連する免疫血管炎を引き起こす【JST・京大機械翻訳】

Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation

著者 (25件)： Noval Rivas Magali (Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Noval Rivas Magali (Department of Pediatrics, Cedars-Sinai Medical Center, and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA) ,  Wakita Daiko (Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Franklin Michael K. (Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Carvalho Thacyana T. (Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Abolhesn Amanda (Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Gomez Angela C. (Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Fishbein Michael C. (Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA) ,  Chen Shuang (Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Chen Shuang (Department of Pediatrics, Cedars-Sinai Medical Center, and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA) ,  Lehman Thomas J. (Hospital for Special Surgery and Weill Medical College of Cornell University, New York, NY, USA) ,  Sato Kazuki (Department of Immunology, Faculty of Medicine; Life Science Center of for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Shibuya Akira (Department of Immunology, Faculty of Medicine; Life Science Center of for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Fasano Alessio (Center for Celiac Research, Mucosal Immunology and Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Boston, MA, USA) ,  Kiyono Hiroshi (International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan) ,  Kiyono Hiroshi (Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California, San Diego, CA, USA) ,  Abe Masanori (Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Tatsumoto Narihito (Departments of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Yamashita Michifumi (Departments of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Crother Timothy R. (Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Crother Timothy R. (Department of Pediatrics, Cedars-Sinai Medical Center, and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA) ,  Shimada Kenichi (Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Shimada Kenichi (Department of Pediatrics, Cedars-Sinai Medical Center, and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA) ,  Arditi Moshe (Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA) ,  Arditi Moshe (Department of Pediatrics, Cedars-Sinai Medical Center, and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA)
資料名： Immunity  (Immunity)
巻： 51  号： 3  ページ： 508-521.e6  発行年： 2019年 
JST資料番号： W1727A  ISSN： 1074-7613  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 患者からの最近の実験データと臨床的,遺伝的およびトランスクリプトームの証拠は,川崎病(KD)の病因におけるインターロイキン-1β(IL-1β)の重要な役割を示唆する。しかし,KD血管炎の間の心血管病変の発生に関与する分子機構はまだ不明である。ここでは,KD血管炎における腸バリア機能およびKD患者における腸透過性および上昇した循環分泌免疫グロブリンA(sIgA)の証拠を検討し,KD血管炎のマウスモデルにおける血管組織におけるsIgAおよびIgA沈着を増加させた。腸透過性を標的とする腸透過性の標的化は,IgA沈着を予防し,マウスモデルにおける心血管病理を改善した。IL-1βシグナル伝達の遺伝学的及び薬理学的阻害を用いて,IL-1βが破壊された腸バリア機能,その後のIgA血管炎発生及び心臓炎症の上流にあることを示した。粘膜バリア機能障害とIL-1β経路を標的とすることは,IgA血管炎とIgA腎症を含む他のIgA関連疾患にも適用できる可能性がある。Copyright 2019 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ヒト ,  *血管 ,  粘膜 ,  インターロイキン1 ,  トランスクリプトーム ,  *免疫グロブリンA ,  心臓 ,  病因 ,  細胞情報伝達 ,  *血管炎 ,  遺伝 ,  ターゲティング ,  分泌
準シソーラス用語： インターロイキン1β ,  マウスモデル ,  バリア機能 , 【Automatic Indexing@JST】

著者キーワード (7件)： 川崎病 ,  IgA ,  腸管透過性 ,  冠動脈炎 ,  血管炎 ,  補体 ,  インターロイキン-1β

分類 (3件)： 免疫反応一般  (ED03010T) ,  細胞生理一般  (EF02010S) ,  消化器の基礎医学  (GH01020E)

タイトルに関連する用語 (6件)： 腸透過性 ,  IgA ,  心 ,  血管炎症 ,  免疫 ,  血管炎