文献

J-GLOBAL ID：201902225957120128   整理番号：19A1650002

線維芽細胞成長因子1はラット幹Leydig細胞発生を促進する【JST・京大機械翻訳】

Fibroblast Growth Factor 1 Promotes Rat Stem Leydig Cell Development

著者 (15件)： Chen Lanlan (Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Chen Lanlan (Department of Anesthesiology, Taizhou People’s Hospital, The Fifth Hospital Affiliated Nantong University, Taizhou, China) ,  Li Xiaoheng (Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Wang Yiyan (Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Song Tiantian (Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Li Huitao (Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Xie Lubin (Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Li Linchao (Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Chen Xianwu (Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Ma Leikai (Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Chen Yong (Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Lv Yao (Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Li Xingwang (Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Ge Ren-Shan (Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Ge Ren-Shan (Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China)
資料名： Frontiers in Endocrinology (Web)  (Frontiers in Endocrinology (Web))
巻： 10  ページ： 118  発行年： 2019年 
JST資料番号： U7068A  ISSN： 1664-2392  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 線維芽細胞成長因子1(FGF1)は精巣で発現することが報告されている。FGF1が幹のLeydig細胞発生にどのように影響するかは不明のままである。ここでは,エタンジメタンスルホナート(EDS)処理モデルにおけるラット幹Leydig細胞発生に及ぼすFGF1の影響を報告する。FGF1(100ng/精巣)は,血清テストステロン濃度を有意に増加させ,PCNA陽性Leydig細胞比率とLeydig細胞数を増加させたが,Leydig細胞のLhcgr,Star,Cyp11a1,HSD3B1,Cyp17a1,Hsd11b1の発現をダウンレギュレーションした。精細管の初代培養により,FGF1は幹Leydig細胞へのEdU取り込みを刺激するが,おそらくFGFR1仲介機構を介してLeydig細胞系譜への分化を阻止することを示した。結論として,FGF1は幹Leydig細胞増殖を促進するが,その分化を阻害する。Copyright 2019 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： aFGF ,  FGF【成長因子】 ,  *Leydig細胞 ,  精巣 ,  ダウンレギュレーション ,  精細管 ,  *ラット ,  血清 ,  初代培養 ,  FGF受容体1 ,  *ネズミ亜目 ,  ステロイド ,  エノン ,  脂環式アルコール ,  脂環式ケトン

著者キーワード (5件)： 線維芽細胞増殖因子1 ,  幹Leydig細胞 ,  差別化 ,  増殖 ,  テストステロン

分類 (2件)： 細胞生理一般  (EF02010S) ,  腫ようの化学・生化学・病理学  (GE02030N)

物質索引 (1件)： テストステロン

引用文献 (43件)：

• Molenaar R, de Rooij DG, Rommerts FF, Reuvers PJ, van der Molen HJ. Specific destruction of Leydig cells in mature rats after in vivo administration of ethane dimethyl sulfonate. Biol Reprod. (1985) 33:1213-22. doi: 10.1095/biolreprod33.5.1213
• Bartlett JM, Kerr JB, Sharpe RM. The effect of selective destruction and regeneration of rat Leydig cells on the intratesticular distribution of testosterone and morphology of the seminiferous epithelium. J Androl. (1986) 7:240-53. doi: 10.1002/j.1939-4640.1986.tb00924.x
• Ge RS, Dong Q, Sottas CM, Papadopoulos V, Zirkin BR, Hardy MP. In search of rat stem Leydig cells: identification, isolation, and lineage-specific development. Proc Natl Acad Sci USA. (2006) 103:2719-24. doi: 10.1073/pnas.0507692103
• Guo J, Zhou B, Chen H, Su Z, Wang G, Wang CQF, et al. Comparison of cell types in the rat leydig cell lineage after ethane dimethanesulfonate treatment. Reproduction. (2013) 145:371-80. doi: 10.1530/REP-12-0465
• Zhang YF, Yuan KM, Liang Y, Chu YH, Lian QQ, Ge YF, et al. Alterations of gene profiles in Leydig-cell-regenerating adult rat testis after ethane dimethane sulfonate-treatment. Asian J Androl. (2015) 17:253-60. doi: 10.4103/1008-682X.136447

タイトルに関連する用語 (5件)： 線維芽細胞成長因子 ,  ラット ,  幹 ,  Leydig細胞 ,  促進