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J-GLOBAL ID：201902227760916130   整理番号：19A0973405

バイオ3D印刷システムを用いたヒト細胞の層状,Trachea様,足場フリー構造によるラット気管の置換【JST・京大機械翻訳】

Replacement of Rat Tracheas by Layered, Trachea-Like, Scaffold-Free Structures of Human Cells Using a Bio-3D Printing System

著者 (35件)： Machino Ryusuke (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Machino Ryusuke (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Matsumoto Keitaro (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Matsumoto Keitaro (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Taniguchi Daisuke (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Taniguchi Daisuke (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Tsuchiya Tomoshi (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Tsuchiya Tomoshi (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Takeoka Yosuke (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Takeoka Yosuke (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Taura Yasuaki (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Taura Yasuaki (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Moriyama Masaaki (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Moriyama Masaaki (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Tetsuo Tomoyuki (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Tetsuo Tomoyuki (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Oyama Shosaburo (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Oyama Shosaburo (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Takagi Katsunori (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Takagi Katsunori (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Miyazaki Takuro (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Miyazaki Takuro (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Hatachi Go (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Hatachi Go (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Doi Ryoichiro (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Doi Ryoichiro (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Shimoyama Koichiro (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Shimoyama Koichiro (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Matsuo Naoto (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Matsuo Naoto (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Yamasaki Naoya (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Yamasaki Naoya (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan) ,  Nakayama Koichi (Department of Regenerative Medicine and Biomedical Engineering Faculty of Medicine, Saga University, Saga, 840-8502, Japan) ,  Nagayasu Takeshi (Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan) ,  Nagayasu Takeshi (Medical-Engineering Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528501, Japan)
資料名： Advanced Healthcare Materials  (Advanced Healthcare Materials)
巻： 8  号： 7  ページ： e1800983  発行年： 2019年 
JST資料番号： W2483A  ISSN： 2192-2640  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 現在の足場に基づく組織工学アプローチは,設計の柔軟性,乏しい細胞適合性,毒性,および移植後の分解のようないくつかの制限を受けている。したがって,足場のない組織工学構造は,臨床移植における古典的足場材料に関連する問題を克服するための有望な解決策となり得る。本研究では,Bio-3D印刷システムを用いて足場のない構造を生成するために用いた培養条件および細胞組合せを最適化することを試みた。ヒト軟骨細胞,ヒト線維芽細胞,ヒト臍静脈内皮細胞,および骨髄からのヒト間葉幹細胞をスフェロイドに凝集させ,3D配置データに従って位置する専用針を持つBio-3D印刷システムに配置し,足場のない気管様チューブを開発した。バイオリアクターにおける特異的媒体の適切な流れによるBio-3D印刷構造の培養は,細胞の再配列と自己組織化を容易にし,物理的強度と組織機能を改善する。Bio-3D印刷組織は,カテーテルを支持するラットに移植された小口径気管様チューブを形成する。チューブはin vivoで生存し,気管上皮と毛細血管は増殖することを確認した。この組織工学,足場のない,管状構造は,バイオエンジニアリングされた器官の臨床応用に向けての重要な段階を表すことができる。Copyright 2019 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： バイオリアクタ ,  *印刷 ,  自己組織化 ,  *三次元 ,  線維芽細胞 ,  生体組織工学 ,  *ヒト ,  生体工学 ,  *気管 ,  柔軟性 ,  最適化 ,  間葉系幹細胞 ,  上皮 ,  *ラット
準シソーラス用語： *三次元印刷 , 【Automatic Indexing@JST】

著者キーワード (5件)： バイオ3Dプリンタ ,  生体工学器官 ,  足場なし ,  組織工学 ,  気管再生

分類 (2件)： 医用素材  (GA05040H) ,  細胞生理一般  (EF02010S)

タイトルに関連する用語 (8件)： 3D印刷 ,  ヒト ,  細胞 ,  層状 ,  足場 ,  ラット ,  気管 ,  置換